Athletics vs Giants Prediction 5/17/25 MLB Picks Today

The Athletics are visiting the San Francisco Giants on Saturday, May 17^th at the Oracle Park in the second game of this series, with the Giants having a 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The Athletics’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the Athletics

Recent betting trends in games played between the Athletics vs San Francisco Giants
A summary that ties it all together and produces a favorable betting outcome for the Athletics vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 26-19 record this season and are sitting in third place in the NL West. They have a 14-7 home record and are 27-18 in over/under. They are coming off a 9-1 home victory over the Athletics, and are 2-5 in their last 7 games. Over is 4-1 in their last 5 games, and they are playing the Nationals and the Royals next.

The Giants have a .239 batting average this season, a .315 OBP, and a .393 Slugging percentage. San Francisco’s pitching staff has a 3.50 ERA and 1.24 WHIP.  Jung Hoo Lee leads the Giants with 50 hits, while Wilmer Flores leads the team in RBI with 41 and in home runs with 10. Heliot Ramos is the team’s best hitter, with a .289 batting average

Landen Roupp (R) will take the mound for the Giants, and he has a 2-3 record, 4.95 ERA, and 1.50 WHIP. He has been better at home, with a 3.72 ERA in two home starts. He has given up at least two runs in seven of his eight starts this season, and this will be his first career start versus the Athletics.

Athletics Preview

The Athletics have a 22-23 record this season and are sitting in the 4^th place in the AL West. The Athletics have a 14-10 road record and are 24-17 in over/under. They are coming off a 1-9 road defeat by the Giants, and are 2-7 in their last 9 games. Over is 7-1 in their last 8 games, and they are playing the Phillies and the Angels next.

The Athletics have a .256 batting average this season, a .315 OBP, and a .423 Slugging percentage. Athletics’ pitching staff has a 5.28 ERA and 1.51 WHIP. Jacob Wilson leads the Athletics with 58 hits and a team-high .341 batting average. Tyler Soderstrom leads the team with 30 RBI.

Luis Severino (R) will take the mound for the Athletics, and he has a 1-4 record, 4.70 ERA, and 1.32 WHIP. He has been excellent on the road, with a 0.95 ERA in three road starts. He is coming off his worst start of the season, as he gave up 8 runs in 4 innings of work in a 12-2 blowout by the Yankees. Luis Severino has a record of 0-1 with an ERA of 2.77 and 11 strikeouts in 2 appearances versus the Giants in his career.

Why the San Francisco Giants will win

• The Athletics have lost nine of their last 10 road games against NL West opponents that held a winning record.
• The Giants have won seven of their last eight home games against AL West opponents.
• The Giants have covered the run line in each of their last seven games at Oracle Park.
• The Athletics have failed to cover the run line in each of their last five road games after playing the previous day.
• The Giants have led after 3 innings in each of their last four games as home favorites.
• The Giants have led after 5 innings in each of their last four games against AL West opponents that held a losing record.

Why the Athletics will win

• The Giants have lost each of their last six night games following a win.
• The Athletics have won seven of their last 10 games as road underdogs against National League opponents following a loss.
• The Giants have failed to cover the run line in each of their last six night games following a win.
• The underdogs have covered the run line in eight of the Giants’ last nine games.
• The Giants have trailed after 3 innings in five of their last six games as favorites against American League opponents.
• The Giants have trailed after 5 innings in three of their last four night games against American League opponents.

Total Runs Facts

• Each of the Athletics’ last 10 games as underdogs have gone OVER the total runs line.
• Seven of the Giants’ last eight games as favorites against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five games between the Athletics and Giants.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Athletics’ last five games at Oracle Park.

Matchup/League Facts

• The Giants rank T3rd in the league for home runs allowed this season (37).
• The Giants rank 8th in the league for runs scored this season (218).
• The Athletics rank 30th in the league for walks allowed this season (184).
• The Athletics rank 29th in the league for hits allowed this season (423).

Athletics vs Giants Prediction

The Giants are 3-1 in their last 4 overall meetings against the Athletics, and 4-1 in their last 5 meetings in San Francisco. Under is 4-1 in their last 5 meetings.

In this Athletics vs Giants Prediction, the Giants are coming as -130 home favorites. The Giants are rightfully favored, as they have a better overall record and have been extremely strong at home. The Giants also have the best bullpen in the MLB, and are hitting better than the A’s. Deeper analytics show that Roupp is better than Severino this season (3.42 vs 4.53 expected ERA), so I like the Giants in this spot. Take the San Francisco Giants on the moneyline at a decent price.