Athletics vs Guardians Prediction 6/22/25 MLB Picks Today

In this article, we will formulate an Athletics vs Guardians prediction for this MLB game on Sunday, June 22, at Sutter Health Park in Sacramento, California. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Betting Preview

The Cleveland Guardians (38-37, 19-22 Away) were swept by the Seattle Mariners but bounced back with a series win against the San Francisco Giants on the road. Cleveland lost the opening game of the current series against the Athletics, but won Game 2 on Saturday, 4-2. Luis Ortiz got the win after allowing no runs on two hits with ten strikeouts and two walks across 6.0 innings of work.

This season, the Guardians average 3.77 runs per game (25th in the MLB) on a .229/.300/.371 triple-slash. When it comes to pitching, the Guardians’ staff has a 3.92 ERA (17th) and 1.37 WHIP (23rd). Jose Ramirez leads the Guardians with a .324 batting average, 13 home runs, and 36 RBI this season.

Slade Cecconi will take the mound for the Guardians on Sunday. The 25-year-old right-hander has a 2-3 record in six starts this year with a 4.15 ERA and 1.35 WHIP in 30.1 innings.

Athletics Betting Preview

The Athletics (32-47, 15-26 Home) swept the Kansas City Royals on the road and then earned a split with the Houston Astros. The A’s won six of the last nine games following last night’s 4-2 defeat to the Guardians in Game 2. Mitch Spence took the loss after allowing four runs on eight hits with three strikeouts and one walk in 4.2 innings.

This year, the Athletics average 4.27 runs per game (15th in the MLB) on a .253/.320/.418 triple-slash. When it comes to pitching, the Athletics’ staff has a 5.47 ERA (29th) and 1.50 WHIP (29th). Tyler Soderstrom leads the Athletics with a .249 batting average, 14 home runs, and 45 RBI this season.

The projected starting pitcher for the Athletics is JP Sears, who is 5-6 in 15 starts this season, with a 5.45 ERA and 1.30 WHIP in 76.0 innings.

Total Runs Facts

• Each of the Guardians’ last six road games have gone UNDER the total runs line.
• Each of the Athletics’ last four games as underdogs against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last seven day games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Athletics’ last five games as home underdogs against AL Central opponents.

Matchup/League Facts

• The Athletics rank 2nd in the league for hits this season (681).
• The Athletics rank 29th in the league for ERA this season (5.45).
• The Guardians rank 26th in the league for on-base percentage this season (.300).
• The Guardians rank 25th in the league for runs scored this season (283).

Athletics vs Guardians Prediction

The Guardians won eight of the previous ten H2H encounters, including four of the last five. Six of the last ten H2Hs went Over, and I am going with another one here, even though the opening two games of the series were surprisingly low-scoring. Slade Cecconi is not a pitcher I am confident in, and I am backing the A’s to score multiple runs off of him early on. JP Sears, on the other hand, surrendered multiple runs in each of his previous seven starts, and I’d be shocked if the Guardians fail to score 3+ runs off of him in the first five innings. The A’s have one of the worst bullpens in baseball, so this should be Over.