Athletics vs Houston Astros Prediction 9/25/26 MLB Picks Today

The Houston Astros and the Athletics meet Friday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Athletics prediction.

Starting Pitching Matchup

The Houston Astros will send out Hunter Brown for the start here and Brown is 6-3 with a 3.26 ERA and 120 strikeouts this season. Jacob Lopez will start for the Athletics and is 6-5 with a 5.68 ERA and 108 strikeouts this season.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 7-5 win over the Athletics on Thursday to sit at 79-80 this season.

Astros Alternate Wins & Losses In 4 Straight

Entering Thursday, Yordan Alvarez leads the Astros across the board with a team-high 172 hits, 41 home runs, and 102 RBIs while adding 32 doubles and a triple so far this season. Isaac Paredes has added 142 hits with 26 doubles, a triple, 23 home runs, and 91 RBIs, while Jose Altuve has contributed 126 hits with 24 doubles, 2 triples, 16 home runs, and 45 RBIs on the year. Christian Walker has logged 122 hits with 25 doubles, a triple, 26 home runs, and 83 RBIs, while Cam Smith has chipped in 103 hits with 17 doubles, 6 triples, 20 home runs, and 54 RBIs for Houston up to this point in the season.

Athletics Recap

The Athletics come into this game looking to bounce back from Thursday’s loss to the Astros to sit at 63-96 this season.

Athletics Have Two-Game Win Streak Snapped

Going into Thursday, Jeff McNeil leads the Athletics with a team-high 123 hits while adding 22 doubles, 8 home runs, and 56 RBIs so far this season. Shea Langeliers paces the Athletics with a team-high 23 home runs alongside 109 hits, 21 doubles, and 58 RBIs, while Lawrence Butler has logged 107 hits with 18 doubles, 2 triples, 17 home runs, and 61 RBIs. Tyler Soderstrom has contributed 97 hits with 27 doubles, 3 triples, 19 home runs, and 56 RBIs. Nick Kurtz leads the team with 69 RBIs while adding 90 hits, 15 doubles, a triple, and 21 home runs. Jacob Wilson has chipped in 85 hits with 16 doubles, a triple, 7 home runs, and 37 RBIs for the Athletics up to this point in the season.

Houston Astros @ Athletics Betting Trends: September 25, 2026

• Probable Starting Pitcher: Jacob Lopez      Record this season: 6-5      ERA: 5.68
• Home Record: 0-3
• Last 5 against Astros: 0-0

Why the Athletics will win

• The Athletics have won seven of their last eight games as home underdogs against AL West opponents following a loss.
• The Astros have lost each of their last six games following a win.
• The Athletics have covered the run line in seven of their last eight home games against the Astros following a loss.
• The Astros have failed to cover the run line in each of their last four night games against the Athletics following a win.
• The Astros have trailed after 5 innings in 15 of their last 16 games as road favorites.
• The Astros have trailed after 3 innings in six of their last seven games as road favorites against AL opponents.

• Probable Starting Pitcher: Hunter Brown      Record this season: 6-3      ERA: 3.26
• Road Record: 2-1
• Last 5 against Athletics: 1-3

Why the Houston Astros will win

• The Astros have won seven of their last eight road games against AL opponents that held a losing record.
• The Athletics have lost six of their last seven games after playing the previous day.
• The road team has covered the run line in each of the Astros’ last six games.
• The Astros have led after 3 innings in three of their last four games against opponents that held a losing record.
• The Athletics have trailed after 5 innings in nine of their last 11 games.

Total Runs Facts

• Each of the Athletics’ last 10 night games against AL West opponents have gone OVER the total runs line.
• Five of the Astros’ last six games as favorites against AL opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Jacob Lopez’s last four appearances as a starter.
• There has been no run scored during the first inning in each of Hunter Brown’s last four road appearances as a starter.

Athletics Player Prop Facts

• Zack Gelof has hit at least one home run in three of the Athletics’ last four home games.
• Jacob Lopez has recorded five or more strikeouts in six of his last seven home appearances against opponents that held a losing record.
• Shea Langeliers has recorded at least one hit in each of his last 11 appearances with the Athletics as underdogs against AL West opponents.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in four of the Astros’ last five road games.
• Hunter Brown has recorded a win in three of his last four appearances with the Astros as favorites.
• Hunter Brown has recorded seven or more strikeouts in each of his last five appearances.
• Christian Walker has recorded at least one hit in each of the Astros’ last 10 road games against AL opponents that held a losing record.
• Yordan Alvarez ranks 1st amongst qualified players for Batting Average (.315) this season.

Matchup/League Facts

• The Athletics rank 30th in the league for home runs allowed this season (239).
• The Athletics rank 29th in the league for ERA this season (5.44).
• The Astros rank 30th in the league for steals this season (49).
• The Astros rank T2nd in the league for home runs this season (218).

Houston Astros vs. Athletics Prediction

I’m on the Athletics here. I think the Athletics can get some revenge in this one. Hunter Brown is Houston’s ace, but he’s had spots where his stuff has been iffy and the extremely hitter-friendly nature of Sutter Health Park makes him liable to get hit here. Jacob Lopez has been solid at times this year and I don’t think I trust the Astros lineup against lefties the way I used to, so give me the A’s here.