Athletics vs Houston Astros Prediction 9/26/26 MLB Picks Today

The Houston Astros and the Athletics meet Saturday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Athletics prediction.

Starting Pitching Matchup

The Houston Astros will send out Hayden Wesneski for the start here and Wesneski is 5-2 with a 3.50 ERA and 41 strikeouts this season. Jack Perkins will start for the Athletics here and is 3-12 with a 5.90 ERA and 131 strikeouts this season.

Houston Astros Recap

The Houston Astros come into this game looking to rebound from their 6-5 loss at the hands of the Athletics last time out to fall to 79-81 this season.

Astros Drop 6 Of Last 9

Yordan Alvarez leads the Astros across the board with a team-high 172 hits, 41 home runs, and 102 RBIs while adding 32 doubles and a triple so far this season. Isaac Paredes has added 142 hits with 26 doubles, a triple, 23 home runs, and 91 RBIs, while Jose Altuve has contributed 126 hits with 24 doubles, 2 triples, 16 home runs, and 45 RBIs on the year. Christian Walker has logged 122 hits with 25 doubles, a triple, 26 home runs, and 83 RBIs, while Cam Smith has chipped in 103 hits with 17 doubles, 6 triples, 20 home runs, and 54 RBIs for Houston up to this point in the season.

Athletics Recap

The Athletics come into this game looking to add on to their win over the Astros from Friday to improve to 64-96 this season.

Athletics Win 3 Of Last 4

Jeff McNeil leads the Athletics with a team-high 123 hits while adding 22 doubles, 8 home runs, and 56 RBIs so far this season. Shea Langeliers paces the Athletics with a team-high 23 home runs alongside 109 hits, 21 doubles, and 58 RBIs, while Lawrence Butler has logged 107 hits with 18 doubles, 2 triples, 17 home runs, and 61 RBIs. Tyler Soderstrom has contributed 97 hits with 27 doubles, 3 triples, 19 home runs, and 56 RBIs. Nick Kurtz leads the team with 69 RBIs while adding 90 hits, 15 doubles, a triple, and 21 home runs. Jacob Wilson has chipped in 85 hits with 16 doubles, a triple, 7 home runs, and 37 RBIs for the Athletics up to this point in the season.

Houston Astros @ Athletics Betting Trends: September 26, 2026

• Probable Starting Pitcher: Jack Perkins      Record this season: 3-12      ERA: 5.90
• Home Record: 1-7
• Last 5 against Astros: 1-1

Why the Athletics will win

• The Athletics have won four of their last five games as home underdogs.
• The Astros have lost three of their last four games as favorites.
• The underdogs have covered the run line in five of the Astros’ last six games.
• The Astros have failed to cover the run line in eight of their last 10 games as favorites against AL West opponents.
• The Astros have trailed after 5 innings in 15 of their last 17 games as road favorites.
• The Astros have trailed after 3 innings in six of their last eight games as road favorites against AL opponents.

• Probable Starting Pitcher: Hayden Wesneski       Record this season: 5-2      ERA: 3.50
• Road Record: 3-1
• Last 5 against Athletics: 2-0

Why the Houston Astros will win

• The Astros have won nine of their last 10 night games against AL opponents following a loss.
• The Athletics have lost six of their last seven games against the Astros following a home win.
• The Astros have covered the run line in each of their last nine night games against AL opponents following a loss.
• The Athletics have failed to cover the run line in six of their last seven games against the Astros following a home win.
• The Athletics have trailed after 5 innings in 10 of their last 12 games.

Total Runs Facts

• Each of the Athletics’ last 11 night games against AL West opponents have gone OVER the total runs line.
• Each of the Astros’ last four road games after playing the previous day have gone OVER the total runs line.
• There has been no run scored during the first inning in each of the last four night games between the Astros and Athletics.
• There has been no run scored during the first inning in each of the Astros’ last four night games at Sutter Health Park.

Athletics Player Prop Facts

• Zack Gelof has hit at least one home run in three of the Athletics’ last five home games.
• Jack Perkins has recorded five or more strikeouts in each of his last six appearances against AL West opponents.
• Shea Langeliers has recorded at least one hit in each of his last eight Saturday night appearances with the Athletics as underdogs.

Houston Astros Player Prop Facts

• Christian Walker has hit a home run in each of the Astros’ last four road games against the Athletics.
• Hayden Wesneski has recorded a win in five of his last six appearances with his team as a favorite against AL West opponents .
• Christian Walker has recorded at least one hit in each of the Astros’ last 11 road games against AL opponents that held a losing record.
• Yordan Alvarez ranks 1st amongst qualified players for Batting Average (.315) this season.

Matchup/League Facts

• The Athletics rank 30th in the league for home runs allowed this season (241).
• The Athletics rank 29th in the league for ERA this season (5.44).
• The Astros rank 30th in the league for steals this season (49).
• The Astros rank 2nd in the league for home runs this season (220).

Houston Astros vs. Athletics Prediction

I’m taking the over in this game. I just think this has the makings of a high-scoring game and I look for that to carry over here after Friday’s fireworks. Perkins has struggled at home a lot this season, and I’m not trusting Hayden Wesneski of all pitchers at Sutter Health to keep runs off of the board. Give me the over here.