Athletics vs LA Angels Prediction 9/22/26 MLB Picks Today

The Los Angeles Angels and the Athletics meet Tuesday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Athletics prediction.

Starting Pitching Matchup

The Los Angeles Angels will send out Yusei Kikuchi here and Kikuchi is 1-6 with a 5.02 ERA and 58 strikeouts this season. Brady Basso will start for the Athletics and is 1-3 with a 4.50 ERA and 28 strikeouts this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back from an 8-0 loss at the hands of the Minnesota Twins last time out to sit at 60-96 this season. After this series, the Angels will head on the road for a series against the Seattle Mariners.

Angels Alternate Wins & Losses In 6 Straight

Zach Neto leads the Angels in hits, home runs, and RBIs with a team-high 142 hits, 26 home runs, and 74 RBIs while adding 29 doubles and 5 triples so far this season. Mike Trout has added 119 hits with 25 doubles, 21 home runs, and 53 RBIs, while Nolan Schanuel has contributed 108 hits with 22 doubles, 7 home runs, and 49 RBIs on the year. Jo Adell has logged 101 hits with 16 doubles, a triple, 16 home runs, and 62 RBIs, and Vaughn Grissom has chipped in 94 hits with 22 doubles, 12 home runs, and 66 RBIs. Oswald Peraza has recorded 76 hits with 12 doubles, 2 triples, 7 home runs, and 25 RBIs, while Jorge Soler has added 64 hits with 16 doubles, a triple, 12 home runs, and 49 RBIs for Los Angeles up to this point in the season.

Athletics Recap

The Athletics come into this game looking to rebound from their 1-0 loss at the hands of the Guardians last time out to sit at 61-95 this season. After this series, the Athletics will take on the Astros in a series at home.

Athletics Lose 6 Straight

Jeff McNeil leads the Athletics with a team-high 122 hits while adding 22 doubles, 8 home runs, and 54 RBIs so far this season. Shea Langeliers leads Oakland with a team-high 23 home runs alongside 105 hits, 19 doubles, and 55 RBIs, while Lawrence Butler has logged 102 hits with 17 doubles, a triple, 17 home runs, and 59 RBIs. Tyler Soderstrom has contributed 97 hits with 27 doubles, 3 triples, 19 home runs, and 56 RBIs, and Nick Kurtz leads the team with 69 RBIs while adding 90 hits, 15 doubles, a triple, and 21 home runs. Jacob Wilson has chipped in 85 hits with 16 doubles, a triple, 7 home runs, and 37 RBIs for the Athletics up to this point in the season.

Los Angeles Angels @ Athletics Betting Trends: September 22, 2026

• Probable Starting Pitcher: Brady Basso      Record this season: 1-3      ERA: 4.50
• Home Record: 0-1
• Last 5 against Angels: 0-0

Why the Athletics will win

• The home team has won each of the Athletics’ last seven games.
• The Angels have lost each of their last four road games against teams that held a losing record.
• The Angels have failed to cover the run line in each of their last five games.
• The Athletics have covered the run line in five of their last six night games against the Angels following a loss.
• The Angels have trailed after 3 innings in six of their last seven games at Sutter Health Park against opponents that held a losing record.
• The Angels have trailed after 5 innings in four of their last five games.

• Probable Starting Pitcher: Yusei Kikuchi      Record this season: 1-6      ERA: 5.02
• Road Record: 1-3
• Last 5 against Athletics: 2-3

Why the Los Angeles Angels will win

• The Athletics have lost each of their last four games as home favorites.
• The Angels have won each of their last four games as underdogs against AL West opponents following a loss.
• The Angels have covered the run line in 12 of their last 13 road games following a home loss.
• The Athletics have failed to cover the run line in seven of their last eight games as home favorites against AL West opponents.
• The Athletics have trailed after 5 innings in each of their last eight games.
• The Athletics have trailed after 3 innings in four of their last five night games.

Total Runs Facts

• Each of the Athletics’ last seven night games against AL West opponents have gone OVER the total runs line.
• Twelve of the Angels’ last 15 road games against AL opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Angels’ last four road games against AL opponents.
• There has been no run scored during the first inning in each of the last four night games between the Angels and Athletics.

Athletics Player Prop Facts

• Lawrence Butler has hit at least one home run in three of the Athletics’ last four home games against AL West opponents.
• Zack Gelof has recorded at least one hit in each of his last 13 appearances with the Athletics as favorites.

Los Angeles Angels Player Prop Facts

• Denzer Guzman has hit a home run in each of the Angels’ last three road games against the Athletics.
• Adam Frazier has recorded at least one hit in each of his seven previous appearances with his team as an underdog against the Athletics.
• Mike Trout ranks 8th amongst qualified players for On Base Percentage (.381) this season.

Matchup/League Facts

• The Athletics rank 30th in the league for home runs allowed this season (231).
• The Athletics rank 29th in the league for ERA this season (5.44).
• The Angels rank 30th in the league for runs scored this season (625).
• The Angels rank 30th in the league for home runs this season (148).

Los Angeles Angels vs. Athletics Prediction

I’m on the Angels in this one. The Athetics just look cooked and I don’t trust many A’s starting pitchers, Basso included, at home. I look for the Angels to get to Basso early and to do enough to get the win here so give me the Halos.