Athletics vs Padres Prediction 5/22/26 MLB Picks Today

In this article, we will formulate an Athletics vs Padres Prediction for this MLB matchup on Friday, May 22^nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 29-20 record this season and are sitting in the second place of the NL West. They have a 14-12 home record and are coming off a 4-0 loss against the Dodgers. They will face the Phillies and the Nationals next.

The Padres have a .221 batting average this season, .292 OBP and .366 Slugging percentage. San Diego’s pitching staff has a 3.93 ERA and 1.25 WHIP. Xander Bogaerts is the team’s best hitter with a .247 batting average, also leading the team in RBI with 23. Gavin Sheets adds a team-high 9 home runs.

Walker Buehler (R) is the projected starting pitcher for the Padres, and he has a 3-2 record, 5.01 ERA and 1.35 WHIP.

Athletics Preview

The Athletics have a 26-24 record this season and are sitting in the first place of the AL West. They have a 16-12 away record and are coming off a 3-2 win against the Angels. They will face the Mariners and the Yankees next.

The Athletics have a .249 batting average this season, .329 OBP and .397 Slugging percentage. Oakland’s pitching staff has a 4.26 ERA and 1.41 WHIP. Shea Langeliers is the team’s best hitter with a .321 batting average, also adding a team-high 12 home runs. Nick Kurtz leads the team in RBI with 36.

Jeffrey Springs (L) is the projected starting pitcher for the Athletics, and he has a 3-4 record, 3.93 ERA and 1.20 WHIP.

Athletics @ San Diego Padres Betting Trends: May 22, 2026

• Probable Starting Pitcher: Walker Buehler      Record this season: 3-2      ERA: 5.01
• Home Record: 1-1
• Last 5 against Athletics: 0-0

Why the San Diego Padres will win

• The Athletics have lost 11 of their last 12 road games against NL West opponents that held a winning record.
• The Padres have won eight of their last nine games against the Athletics.
• The Padres have covered the run line in each of their last five games against the Athletics following a loss.
• The Athletics have failed to cover the run line in six of their last seven games against NL West opponents following a win.
• The Athletics have lost the first inning in three of their last four games against NL West opponents that held a winning record.
• The Padres have led after 3 innings in four of their last five games.
• The Padres have led after 5 innings in 10 of their last 11 games against the Athletics.

• Probable Starting Pitcher: Jeffrey Springs      Record this season: 3-4      ERA: 3.93
• Road Record: 1-1
• Last 5 against Padres: 1-1

Why the Athletics will win

• The Padres have lost each of their last eight Friday night games as favorites against American League opponents.
• The Athletics have won five of their last six games as underdogs.
• The Athletics have covered the run line in each of their last 11 games as road underdogs following a road win.
• The Padres have failed to cover the run line in each of their last 10 Friday home games against American League opponents.
• The Athletics have led after 3 innings in five of their last six road games against National League opponents.
• The Athletics have led after 5 innings in five of their last six road games against National League opponents.

Total Runs Facts

• Each of the Padres’ last seven games as favorites have gone UNDER the total runs line.
• Five of the Athletics’ last six night games against NL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last 10 night games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of Jeffrey Springs’ last eight road appearances as a starter.

San Diego Padres Player Prop Facts

• Gavin Sheets has hit a home run in each of his last two home appearances against the Athletics.
• Fernando Tatis Jr. has recorded at least one hit in each of the Padres’ last 12 games against AL West opponents that held a winning record.
• Fernando Tatis Jr. ranks T9th in the league in Steals (12) this season.

Athletics Player Prop Facts

• Zack Gelof has hit a home run in three of the Athletics’ last four games against opponents that held a winning record.
• Nick Kurtz has recorded at least one hit in each of the Athletics’ last seven games against opponents that held a winning record.
• Nick Kurtz ranks 1st amongst qualified players for On Base Percentage (.438) this season.

Matchup/League Facts

• The Padres rank 30th in the league for hits this season (354).
• The Padres rank 30th in the league for batting average this season (.221).
• The Athletics rank 5th in the league for hits this season (425).
• The Athletics rank 5th in the league for batting average this season (.249).

Athletics vs Padres Prediction

The Padres are 8-1 in their last 9 meetings against the Athletics and have won their last three meetings in San Diego.

In this Athletics vs Padres Prediction, the Padres are coming as -135 home favorites. The A’s are coming off three consecutive wins and they managed to win the Angels last night with Soriano on the bump and are now facing a struggling Walker Buehler who has a 5+ ERA. On top of that, the Padres have been terrible against left-handed pitching, ranking 26^th in the season and dead last in the past couple of weeks, so I expect them to have trouble against Jeffrey Springs, who has been better on the road. Take the A’s on the moneyline on the road for plus money.