Athletics vs White Sox Prediction 4/25/25 MLB Picks Today

The Chicago White Sox and the Athletics meet Friday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs White Sox Prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Burke for the start here and Burke is 1-3 with a 6.23 ERA and 15 strikeouts this season. In his career, Burke is 1-1 with a 7.56 ERA and 7 strikeouts against the Athletics. The Athletics will start Luis Severino here and Severino is 1-3 with a 3.31 ERA and 22 strikeouts this season. In his last five starts against the White Sox, Severino is 1-1 with a 2.91 ERA and 41 strikeouts.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their rain-shortened 3-0 win over the Twins to improve to 6-19 on the year. After this series, the White Sox will head home for a series against the Milwaukee Brewers.

White Sox Snap Losing Streak & Salvage Win Vs. Twins

Lenyn Sosa leads the White Sox with 22 hits including 3 doubles and 6 RBIs. Andrew Benintendi has 15 hits including 4 home runs, 9 RBIs and a .246 batting average while Miguel Vargas has a team-high 5 doubles and 7 RBIs. Brooks Baldwin has also added 10 RBIs while Luis Robert Jr. has a team-high 7 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox while Andrew Vaughn has 3 home runs and 10 RBIs as well this season.

Why the Chicago White Sox will win

• The Athletics have lost each of their last four games as home favorites following a home win.
• The White Sox have won three of their last four games as underdogs against AL West opponents following a win.
• The Athletics have failed to cover the run line in eight of their last nine home games against teams that held a losing record.
• The underdogs have covered the run line in eight of the Athletics’ last 10 games at Sutter Health Park.

Chicago White Sox Player Prop Facts

• Luis Robert ranks T10th in the league in Steals (7) this season.

Athletics Recap

The Athletics will be out to build on their 4-3 win over the Texas Rangers from Thursday’s rubber match to improve to 12-13 on the year. After this series, the Athletics will square off once again in a series on the road against the Texas Rangers.

Athletics Win 6 Of Their Last 9

Jacob Wilson leads the Athletics with 31 hits, 6 doubles and a .330 batting average while Tyler Soderstrom has 28 hits with 9 home runs and 21 RBIs this season. Brent Rooker has 24 hits with 7 home runs and 13 RBIs but also has a team-high 30 strikeouts this season while Max Muncy has 21 strikeouts. Lawrence Butler’s also chipped in 5 stolen bases and 6 doubles as part of his 26 hits.

Why the Athletics will win

• The White Sox have lost each of their last seven night games following a road win.
• The Athletics have won six of their last seven night games against American League opponents.
• The White Sox have failed to cover the run line in each of their last seven night games following a road win.
• The Athletics have covered the run line in each of their last seven games against American League opponents after playing the previous day.

Athletics Player Prop Facts

• Tyler Soderstrom ranks T1st in the league in Home Runs (9) this season.

Total Runs Facts

• Each of the Athletics’ last five home games after playing the previous day have gone UNDER the total runs line.
• Twelve of the White Sox’s last 15 road games against AL West opponents have gone UNDER the total runs line.

Athletics vs White Sox Prediction

I’m on the Athletics here. I get the case to be made for the White Sox as a heavy underdog, as the plus money can be tempting because you don’t normally associate these heavy favorite prices with the Athletics. However, the Athletics have been swinging a hot bat as of late, and I just can’t trust the White Sox to string consistent offense together if I’m being honest. Severino’s faced some tough lineups at home and just held his own against a hot Mets team. I think he can shut down the White Sox here, who continue to struggle to score more than three runs in a game. Give me the Athletics -1.5.