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Braves vs Astros Prediction 9/12/25 MLB Picks Today

Houston Astros (79-68) vs. Atlanta Braves (65-81)
September 12, 2025 7:15 pm EDT
The Line: Atlanta Braves +112 / Houston Astros -137; Over/Under: 8
(Get latest betting odds)

The Houston Astros and the Atlanta Braves meet Friday in MLB action from Truist Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Braves vs Astros Prediction.

Starting Pitching Matchup

The Houston Astros did not have a starting pitcher announced at the time that this article was posted. The Atlanta Braves will start Hurston Waldrep here and Waldrep is 4-0 with a 1.33 ERA and 38 strikeouts this season. This will be Waldrep’s first career start against the Astros.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from their 6-0 loss at the hands of the Toronto Blue Jays to sit at 79-68 this season. After this series, Houston will head home for a division rivalry series against the Texas Rangers.

Astros Drop 5 Of Last 7

Jose Altuve has 142 hits including 22 doubles, 24 home runs and 69 RBIs. Jeremy Pena also has 137 hits with 26 doubles, 15 homers and 54 RBIs with 20 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 22 home runs and 76 RBIs but has also accrued a team-high 156 strikeouts so far this season. Altuve also has 9 stolen bases while Jake Meyers has 15 stolen bases this season. Isaac Paredes also has 19 home runs with 50 RBIs of his own and Cam Smith has contributed 8 homers and 49 RBIs. Yainer Diaz has also chipped in 120 hits with 18 home runs, 60 RBIs and 20 doubles.

Why the Houston Astros will win

  • The road team has won each of the last seven games between the Astros and Braves.
  • The Braves have lost seven of their last eight games against American League opponents following a home loss.
  • The Braves have failed to cover the run line in each of their last eight games against American League opponents following a home loss.
  • The Astros have covered the run line in each of their last six games following a loss.

Houston Astros Player Prop Facts

  • Christian Walker has hit a home run in four of the Astros’ last five road games against opponents that held a losing record.
  • Yainer Diaz has recorded a Double in each of the Astros’ last three night games.
  • Jeremy Pena has recorded at least one hit in each of his last 14 appearances against NL opponents that held a losing record.
  • Jeremy Pena ranks 6th amongst qualified players for Batting Average (.300) this season.

Atlanta Braves Recap

The Atlanta Braves come into this game looking to rebound from a 3-2 loss to the Chicago Cubs last time out to slip to 65-81 this season. After this series, the Braves will head on the road for a series against the Washington Nationals.

Braves Drop 4 Of Their Last 5

Austin Riley has 108 hits including 16 home runs, 54 RBIs and 20 doubles so far this season. Ozzie Albies has 134 hits with 16 home runs and 65 RBIs in addition to 14 stolen bases and Matt Olson has 150 hits with 36 doubles, 23 home runs and 80 RBIs of his own. Marcell Ozuna also has 98 hits with 20 home runs and 62 RBIs. Michael Harris II also has 133 hits with 22 doubles, 6 triples, 17 home runs and 79 RBIs and 15 stolen bases as well and Nick Allen has 8 stolen bases as well this season.

Why the Atlanta Braves will win

  • The underdogs have won each of the Astros’ last four games at Truist Park.
  • The Astros have lost three of their last four games as favorites.
  • The Braves have covered the run line in seven of their last eight games as underdogs following a loss.
  • The Astros have failed to cover the run line in each of their last five games as favorites following a road loss.

Atlanta Braves Player Prop Facts

  • Jarred Kelenic has recorded at least one hit in each of his last 19 home appearances against AL opponents.
  • Jurickson Profar has hit a home run in each of the Braves’ last two games as underdogs against AL opponents.
  • Austin Riley has recorded a Double in each of the Braves’ last three games against the Astros.

Total Runs Facts

  • Each of the Braves’ last seven night games as underdogs have gone UNDER the total runs line.
  • Seven of the Astros’ last eight games as favorites have gone UNDER the total runs line.

Braves vs Astros Prediction

I’m on Atlanta here. Admittedly, I’m a fan of Waldrep’s game and what he’s brought to this Atlanta rotation this season. Houston just has really been stumbling as of late, and say what you want about Atlanta and the issues this team has had this season, they’ve been really strong in Waldrep’s outings, going 6-1 in his 7 appearances so far this season. Give me Atlanta.

Chris Ruffolo's Free Pick: Atlanta Braves +112

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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