Orioles vs Red Sox Prediction 8/27/25 MLB Picks Today

The Boston Red Sox and the Baltimore Orioles meet Wednesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Orioles vs Red Sox Prediction.

Starting Pitching Matchup

The Boston Red Sox will send out Brayan Bello for the start here and Bello is 10-6 with a 3.07 ERA and 102 strikeouts this season. In his last five starts against the Orioles, Bello is 3-1 with a 3.16 ERA and 28 strikeouts. Dietrich Enns will get the start for the Orioles and is 1-2 with a 4.97 ERA and 32 strikeouts this season.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to add on to their 5-0 win over the Orioles on Tuesday to sit at 73-60 this season. After this series, the Red Sox will head home for a series against the Pittsburgh Pirates.

Red Sox Win 5 Of Their Last 6

Alex Bregman has 96 hits including 24 doubles along with 16 home runs and 53 RBIs this season. Trevor Story’s added 127 hits with 20 home runs, 82 RBIs and 22 stolen bases while Jarren Duran has 131 hits with 34 doubles, 12 triples, 12 home runs, 70 RBIs and a team-high 21 stolen bases. Kristian Campbell’s added 51 hits with 10 doubles, 6 homers and 21 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 14 homers, 26 doubles, 3 triples, 53 RBIs and 19 stolen bases this season.

Why the Boston Red Sox will win

• The road team has won each of the last six games between the Red Sox and Orioles.
• The Orioles have lost each of their last five night games against American League opponents that held a winning record.
• The road team has covered the run line in 10 of the Orioles’ last 11 games.
• The Orioles have failed to cover the run line in five of their last six games against teams that held a winning record.

Boston Red Sox Player Prop Facts

• Jarren Duran has recorded at least one hit in each of the Red Sox’s last 13 Wednesday night games against opponents that held a losing record.
• Trevor Story has hit a home run in three of the Red Sox’s last four games as road favorites against the Orioles.
• Connor Wong has recorded a Double in four of his last five road appearances against AL opponents.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from their loss at the hands of the Red Sox last time out to sit at 60-72 this season. After this series, the Orioles will take to the road for an interleague series against the San Francisco Giants.

Orioles On Flipside, Lose 5 Of 6

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 118 hits with 17 doubles, 2 triples, 15 homers and 49 RBIs. Gunnar Henderson has 128 hits with 29 doubles, 5 triples, 15 home runs and 57 RBIs with 16 stolen bases and 112 strikeouts while Holliday has a team-high 116 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 15 home runs and 34 RBIs this season.

Why the Baltimore Orioles will win

• The Orioles have won three of their last four games as home underdogs against AL East opponents following a loss.
• The Red Sox have lost three of their last four games as favorites against the Orioles following a win.
• The underdogs have covered the run line in 16 of the Orioles’ last 18 games.
• The Red Sox have failed to cover the run line in six of their last seven night games against AL East opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Colton Cowser has hit a home run in three of the Orioles’ last four night games against opponents that held a winning record.
• Colton Cowser has recorded at least one hit in each of the Orioles’ last seven games against AL opponents that held a winning record.

Total Runs Facts

• Six of the Orioles’ last seven games as home underdogs have gone UNDER the total runs line.
• Five of the Red Sox’s last six games as favorites against the Orioles have gone UNDER the total runs line.

Orioles vs Red Sox Prediction

I’m backing the Red Sox here. I just have a lot more faith in Brayan Bello to have a solid start here than I trust the Orioles to back up Dietrich Enns. Furthermore, I don’t love Boston’s form against a lefty in the last couple of weeks, but Boston’s just in far better form and I think they get it done. Give me Boston here.