Baltimore Orioles vs Houston Astros Prediction 4/29/26 MLB Picks Today

The Houston Astros and the Baltimore Orioles meet Wednesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The Houston Astros will send out Peter Lambert for the start here and Lambert is 1-1 with a 3.27 ERA and 16 strikeouts this season. This will be Lambert’s first career start against the Orioles. Chris Bassitt will start for the Orioles in this one and is 1-2 with a 6.75 ERA and 10 strikeouts this season. In his last five starts against the Astros, Bassitt is 2-3 with a 4.34 ERA and 19 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from their 5-3 loss at the hands of the Baltimore Orioles last time out to sit at 11-19 on the year. After this series, the Astros will head on the road for a set against the Boston Red Sox.

Astros Drop 3 Of Last 4

Entering Tuesday, Yordan Alvarez has 38 hits with 9 doubles, 11 home runs and 26 RBIs while Christian Walker has 30 hits with 8 doubles, 7 home runs and 23 RBIs on the year. Jose Altuve’s chipped in 27 hits with 7 doubles, 3 home runs and 8 RBIs and Carlos Correa has 27 hits with 7 doubles, 2 home runs and 14 RBIs. Cam Smith also has 21 hits with 5 doubles, 3 home runs and 11 RBIs. Yainer Diaz also has 17 hits with 3 doubles, 2 home runs and 12 RBIs.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their win over Houston from Tuesday to sit at 14-15 this season. After this series, the Orioles will head on the road for a series against the New York Yankees.

Orioles Snap Two-Game Slide

Going into Tuesday, Taylor Ward has 34 hits with 13 doubles and 11 RBIs while Gunnar Henderson has 25 hits with 4 doubles, 9 home runs and 18 RBIs and Pete Alonso has 21 hits with 6 doubles, 3 home runs and 10 RBIs. Adley Rutschman has 17 hits with 6 doubles, 3 home runs and 11 RBIs. Jeremiah Jackson has 24 hits with 2 doubles, 5 home runs and 19 RBIs while Dylan Beavers also has 17 hits with 3 doubles, 2 home runs and 8 RBIs.

Houston Astros @ Baltimore Orioles Betting Trends: April 29, 2026

• Probable Starting Pitcher: Chris Bassitt      Record this season: 1-2      ERA: 6.75
• Home Record: 0-1
• Last 5 against Astros: 2-3

Why the Baltimore Orioles will win

• The Astros have lost each of their last nine road games against teams that held a losing record.
• The Orioles have won four of their last five night games against teams that held a losing record.
• The Astros have failed to cover the run line in eight of their last nine road games against teams that held a losing record.
• The Orioles have covered the run line each of their last five night games against teams that held a losing record.
• The Astros have lost the first inning in each of their last six road games against opponents that held a losing record.
• The Astros have trailed after 5 innings in eight of their last nine road games against opponents that held a losing record.
• The Orioles have led after 3 innings in four of their last five home night games.

• Probable Starting Pitcher: Peter Lambert      Record this season: 1-1      ERA: 3.27
• Road Record: 1-0
• Last 5 against Orioles: –

Why the Houston Astros will win

• The Orioles have lost each of their last six games as favorites against American League opponents following a home win.
• The Astros have won four of their last five games as underdogs against the Orioles following a loss.
• The Orioles have failed to cover the run line in each of their last seven games against American League opponents following a home win.
• The Astros have covered the run line in each of their last seven night games against AL East opponents following a road loss.
• The Astros have won the first inning in three of their last four games against AL East opponents that held a losing record.
• The Orioles have trailed after 5 innings in each of their last nine Wednesday night games against opponents that held a losing record.
• The Orioles have trailed after 3 innings in six of their last seven night games against AL West opponents.

Total Runs Facts

• Each of the Orioles’ last six games after playing the previous day have gone OVER the total runs line.
• Ten of the Astros’ last 11 night games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 15 games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last seven Wednesday games against AL West opponents.

Baltimore Orioles Player Prop Facts

• Pete Alonso has hit a home run in each of his last two appearances against AL West opponents that held a losing record.
• Chris Bassitt has recorded five or more strikeouts in each of his last nine home appearances against AL opponents that held a losing record.
• Colton Cowser has recorded at least one hit in each of his last 16 appearances against AL West opponents.
• Taylor Ward ranks 5th amongst qualified players for On Base Percentage (.426) this season.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in four of the Astros’ last six night games against AL opponents that held a losing record.
• Yainer Diaz has recorded at least one hit in each of his 12 previous appearances against the Orioles after playing the previous day.
• Yordan Alvarez ranks 1st in the league in Hits (39) this season.

Matchup/League Facts

• The Orioles rank T26th in the league for triples this season (1).
• The Orioles rank 25th in the league for steals this season (15).
• The Astros rank 1st in the league for doubles this season (66).
• The Astros rank 30th in the league for ERA this season (5.96).

Houston Astros vs. Baltimore Orioles Prediction

I’m on the over here. Lambert pitched well in his last start but I don’t really trust him long term as I feel like I need to see more than just 11 innings of work and the Astro bullpen behind him is still brutal. On the flipside, Chris Bassitt hasn’t looked good for much of the year and the Astro bats have started to heat up. I think this is going to be a high-scoring game so give me the over here.