Baltimore Orioles vs NY Yankees Prediction 9/19/25 MLB Picks Today

The New York Yankees and the Baltimore Orioles meet Friday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The New York Yankees will start Will Warren here and Warren is 8-7 with a 4.44 ERA and 160 srikeouts this season. In his career, Warren is 0-1 with a 5.59 ERA and 11 strikeouts against Baltimore. Trevor Rogers will start here for the Orioles and is 8-2 with a 1.43 ERA and 93 strikeouts this season. In his career, Rogers is 0-0 with a 2.70 ERA and 8 strikeouts against the Yankees.

New York Yankees Recap

The New York Yankees come into this game looking to add on to their 7-0 win over the Orioles from Thursday’s series opener to sit at 86-67 this season. After this series, the Yankees will head home for a series against the Chicago White Sox.

Yankees Win Three In A Row

Aaron Judge leads the Yankees with 163 hits including 48 home runs, 102 RBIs, 28 doubles and a .326 batting average along with 11 stolen bases. Anthony Volpe’s also had 29 doubles with 16 stolen bases, 19 home runs and 70 RBIs while Jasson Dominguez has added 17 doubles of his own. Paul Goldschmidt has 126 hits with 30 doubles and a .278 batting average while Volpe also has 140 strikeouts so far this season. Ben Rice also has 105 hits with 25 doubles, 23 home runs and 56 RBIs while Cody Bellinger has 28 homers with 93 RBIs and Austin Wells has 21 home runs and 66 RBIs with Bellinger logging 25 doubles and Wells chipping in 19 doubles. Trent Grisham also has 30 home runs and 64 RBIs and Jazz Chisholm Jr. has 29 home runs and 75 RBIs so far this season.

Why the New York Yankees will win

• The Orioles have lost each of their last eight games against AL East opponents.
• The Yankees have won each of their last six games against AL East opponents that held a losing record.
• The Yankees have covered the run line each of their last six games against AL East opponents that held a losing record.
• The Orioles have failed to cover the run line in four of their last five home games.

New York Yankees Player Prop Facts

• Giancarlo Stanton has hit at least one home run in three of the Yankees’ last four games against AL East opponents that held a losing record.
• Anthony Volpe has recorded at least one Double in each of the Yankees’ last four games as road favorites against the Orioles.
• Anthony Volpe has recorded at least one hit in 17 of his last 18 road appearances against AL opponents that held a losing record.
• Jose Caballero ranks 1st in the league in Steals (48) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from their loss at the hands of the Yankees in Thursday’s opener to drop to 72-81 this season. After this series, the Orioles will square off against the Tampa Bay Rays in a series at home.

Orioles Have Three-Game Win Streak Snapped

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 138 hits with 20 doubles, 3 triples, 17 homers and 55 RBIs. Gunnar Henderson has 143 hits with 32 doubles, 5 triples, 16 home runs and 62 RBIs with 23 stolen bases and 128 strikeouts while Holliday has a team-high 130 strikeouts as well this season. 

Why the Baltimore Orioles will win

• The Orioles have won 11 of their last 12 night games against the Yankees following a loss.
• The Yankees have lost 10 of their last 11 night games against the Orioles following a win.
• The Yankees have failed to cover the run line in 12 of their last 14 night games against the Orioles following a win.
• The Orioles have covered the run line in 11 of their last 13 night games against the Yankees following a loss.

Baltimore Orioles Player Prop Facts

• Trevor Rogers has recorded six or more strikeouts in each of his last seven appearances against opponents that held a winning record.
• Gunnar Henderson has recorded a hit in each of the Orioles’ last seven home games against the Yankees.
• Dylan Carlson has recorded a Double in each of his last three home appearances against AL East opponents.
• Tyler O’Neill has hit a home run in three of his last five home appearances after playing the previous day.

Total Runs Facts

• Each of the Orioles’ last 12 home games have gone UNDER the total runs line.
• Each of the Yankees’ last six games as favorites against AL East opponents have gone UNDER the total runs line.

New York Yankees vs. Baltimore Orioles Prediction

I’m on the Orioles in this one. I just think that while the Yankees are the better team, they’re not going to win every single matchup down the stretch, and there are going to be spots that just go against New York, and this is one of those. Will Warren’s been far less effective on the road this season and the Yankees have dropped a decent number of his starts. You could argue Rogers has been Baltimore’s best arm this season by a fair margin and I think that the Orioles get one here. Give me the O’s.