Blue Jays vs Cubs Prediction 6/21/26 MLB Picks Today

In this article, we will formulate a Blue Jays vs Cubs Prediction for this MLB matchup on Sunday, June 21^st in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 40-37 record this season and are sitting in the 3rd place of the NL Central. They have a 23-17 home record and are coming off a 6-8 home defeat against the Blue Jays. They will face the Mets and the Brewers next.

The Cubs have a .244 batting average this season, .337 OBP and .401 Slugging percentage. Chicago’s pitching staff has a 4.28 ERA and 1.24 WHIP. Pete Crow-Armstrong is the team’s best hitter with a .286 batting average. Michael Busch leads the team in RBI with 42, while Ian Happ adds a team-high 16 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 4-6 record, 4.26 ERA and 1.06 WHIP.

Toronto Blue Jays Preview

The Toronto Blue Jays have a 38-39 record this season and are sitting in the 3rd place of the AL East. They have a 17-21 road record and are coming off an 8-6 road win against the Cubs. They will face the Astros and the Rangers next.

The Blue Jays have a .249 batting average this season, .311 OBP and .391 Slugging percentage. Toronto’s pitching staff has a 4.13 ERA and 1.31 WHIP. Ernie Clement is the team’s best hitter with a .292 batting average. Kazuma Okamoto leads the team in RBI with 45, adding a team-high 16 home runs.

Dylan Cease (R) is the projected starting pitcher for the Blue Jays, and he has a 4-3 record, 2.71 ERA and 1.19 WHIP.

Toronto Blue Jays @ the Chicago Cubs Betting Trends: June 21, 2026

• Probable Starting Pitcher: Shota Imanaga      Record this season: 4-6      ERA: 4.26
• Home Record: 3-3
• Last 5 against Blue Jays: 0-1

Why the Chicago Cubs will win

• The Cubs have won five of their last six games as home underdogs against American League opponents following a loss.
• The Blue Jays have lost three of their last four games as road favorites following a win.
• The Blue Jays have failed to cover the run line in each of their last five games against National League opponents following a win.
• The underdogs have covered the run line in 13 of the Cubs’ last 15 games at Wrigley Field.
• The Blue Jays have trailed after 5 innings in seven of their last eight games against National League opponents.
• The Cubs have led after 3 innings in 11 of their last 12 home games against AL East opponents.
• The Blue Jays have lost the first inning in four of their last five games as favorites against National League opponents.

• Probable Starting Pitcher: Dylan Cease      Record this season: 4-3      ERA: 2.71
• Road Record: 3-1
• Last 5 against Cubs: 2-0

Why the Toronto Blue Jays will win

• The Cubs have lost eight of their last nine day games against American League opponents.
• The road team has won six of the Blue Jays’ last seven games.
• The Cubs have failed to cover the run line in each of their last eight games against American League opponents following a loss.
• The Blue Jays have covered the run line in 11 of their last 12 road games against NL Central opponents that held a winning record.
• The Blue Jays have won the first inning in three of their last four games as road favorites against National League opponents.
• The Blue Jays have led after 5 innings in seven of their last eight games as road favorites against NL Central opponents.
• The Blue Jays have led after 3 innings in six of their last eight day games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Cubs’ last four games against American League opponents have gone OVER the total runs line.
• Each of the Blue Jays’ last four road games against National League opponents have gone OVER the total runs line.
• There has been no run scored during the first inning in seven of Shota Imanaga’s last eight home appearances as a starter.
• There has been at least one run scored in the first inning in six of the Blue Jays’ last seven games as favorites against National League opponents.

Chicago Cubs Player Prop Facts

• Carson Kelly has hit a home run in two of his last three home appearances against the Blue Jays.
• Seiya Suzuki has recorded at least one hit in each of his last 12 appearances after playing the previous day.
• Pete Crow-Armstrong is one of only two players to record 10+ Home Runs and 4+ Triples this season.

Toronto Blue Jays Player Prop Facts

• George Springer has hit at least one home run in each of his last four appearances with the Blue Jays as road favorites against NL Central opponents.
• Dylan Cease has recorded seven or more strikeouts in each of his last seven appearances.
• George Springer has recorded at least one hit in each of his last 14 road appearances against NL Central opponents.
• Dylan Cease has recorded a win in each of his last three appearances with the Blue Jays as road favorites.
• Dylan Cease ranks 3rd in the league for total Strikeouts (110) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks this season (338).
• The Cubs rank 30th in the league for home runs allowed this season (113).
• The Blue Jays rank 30th in the league for triples this season (4).
• The Blue Jays rank 2nd in the league for strikeouts against this season (562).

Blue Jays vs Cubs Prediction

The Jays are 4-2 in their last 6 meetings against the Cubs and have won two of their last three visits in Chicago.

In this Blue Jays vs Cubs Prediction, the Blue Jays are coming as -130 road favorites. The Jays are being favorited in Chicago even though they lost in the opening game of this series by 2-16 and are facing a leftie in Imanaga. I will gladly take the plus money with the home team, as Imanaga has bounced back and has one earned run in his last two starts, the Cubs have a slightly better bullpen and a superior offense, with the Jays being weaker against southpaws. Take the Cubs to win.