Blue Jays vs Padres Prediction 5/21/25 MLB Picks Today

The San Diego Padres and Toronto Blue Jays meet Wednesday in MLB action at Rogers Centre. Here’s a Blue Jays vs Padres Prediction. This article will include a Blue Jays vs Padres Pick.

San Diego Padres Betting Preview

The San Diego Padres are 27-19 on the year and play the Braves, Marlins, and Pirates next. The San Diego Padres are batting .259 on the season, have a .326 OBP, and a .392 slugging percentage. The San Diego Padres pitching staff has a 3.39 ERA and a 1.16 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 53 hits and 27 RBI, while Manny Machado and Luis Arraez have combined for 100 hits and 35 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 3-3 with a 3.45 ERA and 23 strikeouts this season. This will be Vasquez’s second career game against the Toronto Blue Jays.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 23-24 on the year and play the Rays, Rangers, and Athletics next. The Toronto Blue Jays are batting .247 on the season, have a .316 OBP, and a .379 slugging percentage. The Toronto Blue Jays’ pitching staff has a 4.21 ERA and a 1.23 WHIP. Bo Bichette leads the Toronto Blue Jays with 57 hits and 22 RBI, while Vladimir Guerrero Jr. and Alejandro Kirk have combined for 89 hits and 39 RBI.

Kevin Gausman gets the ball for the Toronto Blue Jays, and he is 3-4 with a 4.59 ERA and 46 strikeouts this season. Gausman is 2-1 with a 3.35 ERA and 43 strikeouts in his career against the San Diego Padres.

Why the Toronto Blue Jays will win

• The Padres have lost eight of their last nine games against American League opponents following a loss.
• The Blue Jays have won each of their last five night games following a home win.
• The Blue Jays have covered the run line each of their last seven night games against teams that held a winning record.
• The Padres have failed to cover the run line each of their last six games against AL East opponents that held a losing record.
• The Blue Jays have won the first inning in four of their last five games as favorites against NL West opponents.
• The Blue Jays have led after 3 innings in each of their last four games as favorites against NL West opponents.
• The Blue Jays have led after 5 innings in each of their last four night games against National League opponents that held a winning record.

Why the San Diego Padres will win

• The Blue Jays have lost each of their last four games as favorites following a win.
• The underdogs have won each of the Padres’ last four games.
• The Padres have covered the run line in each of their last seven games as underdogs against American League opponents following a road loss.
• The Blue Jays have failed to cover the run line in each of their last four home games following a win.
• The Blue Jays have trailed after 3 innings in four of their last five games.
• The Padres have led after 5 innings in six of their last seven night games against opponents that held a losing record.

Toronto Blue Jays Player Prop Facts

• Daulton Varsho has hit a home run in three of his last four appearances with the Blue Jays as favorites against NL West opponents.
• Daulton Varsho has recorded at least one RBI in each of his last four appearances with the Blue Jays as favorites against NL West opponents.
• Kevin Gausman has recorded a win in each of his last three appearances in night games against teams that held a winning record.
• Vladimir Guerrero Jr. has scored at least one run in each of the Blue Jays’ last seven games as favorites.
• Kevin Gausman has recorded five or more strikeouts in 11 of his last 13 appearances with his team as a favorite against NL West opponents.
• Bo Bichette has recorded at least one Single in each of his 12 previous Wednesday appearances against NL teams that held a winning record.
• Vladimir Guerrero Jr. has recorded at least one hit in each of the Blue Jays’ last nine games as favorites.
• Bo Bichette ranks T9th in the league in Hits (57) this season.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in three of the Padres’ last five night games against opponents that held a losing record.
• Jackson Merrill has recorded at least one RBI in five of his last six road appearances after playing the previous day.
• Manny Machado has scored a run in each of the Padres’ last five games as underdogs.
• Jason Heyward has recorded at least one hit in each of his last eight road appearances against AL East opponents that held a losing record.
• Fernando Tatis Jr. has recorded a Single in each of the Padres’ last six road games.
• Fernando Tatis Jr. ranks T8th in the league in Home Runs (12) this season.

Blue Jays vs Padres Prediction

The Blue Jays are getting love at home with Gausman on the mound, but he’s allowed 17 hits and nine runs in his last 11 innings. Gausman has allowed 19 runs in his last 19.2 innings. Vasquez has been more reliable this season, and that includes giving up 16 hits and four runs in his last 17 innings. The Padres are 3-0 with Vasquez on the mound this month. Also, it’s only a matter of time before the Padres wake up offensively, as this lineup is too talented to score just three runs in their last four games. The market is starting to shift on the Padres. I’ll take a shot with them in a bounce-back spot.