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Blue Jays vs Red Sox Prediction 4/29/26 MLB Picks Today

Boston Red Sox (12-18) vs. Toronto Blue Jays (13-16)
April 29, 2026 3:07 pm EDT
The Line: Toronto Blue Jays -131 / Boston Red Sox 109; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a Blue Jays vs Red Sox prediction for this MLB game on Wednesday, April 29th at the Rogers Centre in Toronto, Ontario. Let’s take a look at the prediction for this MLB matchup. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 13-16 this year after they split the first two games in this series by scores of 0-5 and 3-0. In game two, Toronto jumped out to a 2-0 lead in the third inning and never looked back in the win. The Blue Jays recorded six hits in the game and they were led by Okamoto, who went 1-4 with two RBIs. Yesavage allowed four hits and zero earned runs over 5.1 innings for the win, while Varland picked up the save. Prior to this series, Toronto won two out of three against the Guardians and two out of three against the Angels. 

This season, Toronto has a 4.31 ERA with a 1.30 WHIP and a .243 opponent batting average, while they have scored 113 runs with a .248 batting average and a .309 on base percentage. Andres Gimenez has led the Blue Jays with three home runs and 16 RBIs, while Jesus Sanchez has added four home runs and 15 RBIs. The projected starting pitcher for Toronto is Eric Lauer, who is 1-3 with a 6.75 ERA and a 1.54 WHIP over 22.2 innings pitched this year. 

Boston Red Sox Betting Preview

The Boston Red Sox are 12-18 this season after they lost game two by a score of 3-0 on Tuesday night. Boston didn’t generate many baserunners in this game and they were shutout for another loss. The Red Sox recorded four hits in the game and they were led by Yoshida, who went 1-3. Tolle allowed three hits and three earned runs over 4.2 innings for the loss, while Watson allowed zero earned runs over 1.2 relief innings. Prior to this series, Boston won two out of three against the Orioles, but lost all three against the Yankees before that. 

This season, Boston has a 4.20 ERA with a 1.30 WHIP and a .243 opponent batting average, while they have scored 122 runs with a .231 batting average and a .310 on base percentage. Wilson Contreras has led the Red Sox with six home runs and 19 RBIs, while Trevor Story has added two home runs and 17 RBIs. The projected starting pitcher for Boston is Brayan Bello, who is 1-3 with a 9.00 ERA and a 2.27 WHIP over 22.0 innings pitched this season. 

Why the Toronto Blue Jays will win

  • The Blue Jays have won each of their last seven day games against AL East opponents following a home win.
  • The Red Sox have lost each of their last five day games at Rogers Centre following a loss.
  • The Blue Jays have covered the run line in seven of their last eight home games against AL East opponents.
  • The Red Sox have failed to cover the run line in six of their last seven games as underdogs following a loss.
  • The Blue Jays have won the first inning in three of their last four day games at Rogers Centre.
  • The Blue Jays have led after 3 innings in each of their last four day games against AL East opponents.
  • The Blue Jays have led after 5 innings in seven of their last eight home games against American League opponents that held a losing record.

Why the Boston Red Sox will win

  • The Blue Jays have lost each of their last four games as favorites against the Red Sox following a win.
  • The Red Sox have won four of their last five games as road underdogs against AL East opponents following a road loss.
  • The Blue Jays have failed to cover the run line in each of their last seven games as favorites against the Red Sox following a win.
  • The Red Sox have covered the run line in 13 of their last 15 games as road underdogs against AL East opponents following a road loss.
  • The Red Sox have led after 5 innings in each of their last four road day games.
  • The Blue Jays have lost the first inning in three of their last four day games against opponents that held a losing record.
  • The Blue Jays have trailed after 3 innings in seven of their last eight day games against American League opponents.

Total Runs Facts

  • Each of the Blue Jays’ last four games as favorites against the Red Sox have gone UNDER the total runs line.
  • Each of the Red Sox’s last four day games against American League opponents have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last 11 Wednesday games against American League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the last six games between the Red Sox and Blue Jays at Rogers Centre.

Toronto Blue Jays Player Prop Facts

  • George Springer has recorded at least one hit in each of his last 13 home appearances against AL opponents that held a losing record.
  • Alejandro Kirk has hit at least one home run in each of his last three appearances with the Blue Jays as favorites against AL East opponents.

Boston Red Sox Player Prop Facts

  • Willson Contreras has hit a home run in three of the Red Sox’s last four day games.
  • Isiah Kiner-Falefa has recorded at least one hit in each of his 13 previous appearances with his team as a road underdog against the Blue Jays.

Blue Jays vs Red Sox Prediction 

Toronto was able to get the shutout win in game two on Tuesday night, which answered the shutout win by Boston on Monday. The Blue Jays are 9-8 at home this year, while the Red Sox are 7-10 on the road. Boston has won three of their last four games and they just fired their manager a few games ago. The Sox are starting Bello, who has allowed 12 earned runs and 18 hits in his last 7.1 innings, while the Jays are starting Lauer, who has allowed 13 earned runs and 17 hits over his last 15.1 innings. Take the over in this one. 

David Racey's Free Pick: Over 8

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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