Red Sox vs Athletics Prediction 9/17/25 MLB Picks Today

The Athletics and the Boston Red Sox meet Wednesday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Red Sox vs Athletics Prediction.

Starting Pitching Matchup

The Athletics will send out Mason Barnett here and Barnett is 1-1 with an 8.53 ERA and 13 strikeouts this season. This will be Barnett’s second career start against the Red Sox. Lucas Giolito will get the start for teh Red Sox here and is 10-4 with a 3.31 ERA and 113 strikeouts this season. In his career, Giolito is 1-1 with a 4.26 ERA and 27 strikeouts against the Athletics.

Athletics Recap

The Athletics come into this game looking to add on to their 2-1 win over the Red Sox from Tuesday’s series opener to improve to 71-80 this season. After this series, the Athletics will travel to Pittsburgh for an interleague series against the Pirates.

Athletics Push Win Streak To Five

Jacob Wilson has 142 hits, 23 doubles and a .318 batting average while Tyler Soderstrom has 144 hits with 30 doubles, 24 home runs and 88 RBIs this season. Brent Rooker has 158 hits with 40 doubles, 29 home runs and 85 RBIs but also has 139 strikeouts this season while Nick Kurtz has a team-high 32 home runs and 80 RBIs with 24 doubles. Shea Langeliers has 117 hits with 30 home runs and 68 RBIs while Lawrence Butler’s also chipped in 20 stolen bases and 29 doubles as part of his 127 hits as well as 20 home runs and 59 RBIs while also owning a team-high 169 strikeouts this season.

Why the Athletics will win

• The Athletics have won seven of their last eight games as underdogs.
• The Red Sox have lost seven of their last eight home games against teams that held a losing record.
• The Athletics have covered the run line in 17 of their last 18 games as road underdogs.
• The Red Sox have failed to cover the run line in seven of their last eight home games against teams that held a losing record.

Athletics Player Prop Facts

• Zack Gelof has recorded at least one hit in each of his last eight Wednesday appearances with the Athletics as underdogs.
• JJ Bleday has hit at least one home run in each of his last three appearances with the Athletics as road underdogs.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to respond after falling short in Tuesday’s matchup to drop to 82-69 on the year. After this set, the Red Sox will take to the road for a division series against the Tampa Bay Rays.

Red Sox Drop 4 Of Their Last 5

Alex Bregman has 110 hits including 27 doubles along with 17 home runs and 59 RBIs this season. Trevor Story’s added 147 hits with 24 home runs, 91 RBIs and 28 stolen bases while Jarren Duran has 148 hits with 39 doubles, 13 triples, 15 home runs, 80 RBIs and a team-high 23 stolen bases. Roman Anthony’s added 75 hits with 18 doubles, 8 home runs and 32 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 16 homers, 29 doubles, 3 triples, 60 RBIs and 19 stolen bases this season.

Why the Boston Red Sox will win

• The Red Sox have won 10 of their last 12 games against the Athletics following a home loss.
• The Athletics have lost five of their last six night games against AL East opponents following a road win.
• The Red Sox have covered the run line in eight of their last 10 games against the Athletics following a home loss.
• The Athletics have failed to cover the run line in four of their last five night games against American League opponents that held a winning record.

Boston Red Sox Player Prop Facts

• Ceddanne Rafaela has recorded at least one hit in each of his last nine appearances with the Red Sox as home favorites against AL West opponents.
• Lucas Giolito has recorded a win in five of his last six appearances against opponents that held a losing record.
• Triston Casas has hit a home run in four of his last five home appearances against AL West opponents.
• Lucas Giolito has recorded six or more strikeouts in each of his four previous appearances against the Athletics.
• Jarren Duran has recorded at least one Double in six of the Red Sox’s last seven night games against AL West opponents that held a losing record.

Total Runs Facts

• Each of the last six games between the Athletics and Red Sox have gone UNDER the total runs line.
• Each of the Athletics’ last five games as underdogs against the Red Sox have gone UNDER the total runs line.

Red Sox vs Athletics Prediction

I’m on the over in this one. I just don’t trust either starting pitcher in this matchup, as Barnett did get hit by the Red Sox a bit when he faced them last week, but I think we could see some of the same here. On the other side, Lucas Giolito’s been a far more reliable option for Boston, but this Athletics lineup can hit with some of the best. I think this is going to end up being a high-scoring affair, so give me the over in this one.