Boston Red Sox vs San Diego Padres Prediction 05-21-2023 MLB Picks

Chris RuffoloMay 21, 2023
Boston Red Sox vs San Diego Padres Prediction 05-21-2023 MLB Picks player photo
Credit: USA Today Sports

The Boston Red Sox and the San Diego Padres meet in MLB action from Petco Park on Sunday afternoon. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


The Padres are -145 home favorites while the Red Sox are +125 road underdogs. The total for this game is set at 8.5 runs.

Starting Pitching Matchup

Corey Kluber will start for Boston and is 2-5 with a 6.41 ERA and 33 strikeouts this season. Michael Wacha will start for the Padres and is 4-1 with a 4.06 ERA and 41 strikeouts this season.

Matchup History

Boston’s 4-2 win on Saturday made it back-to-back wins and wins in 6 of the last 7 meetings for the Red Sox over the Padres in this head-to-head matchup.


Boston is 5-2 in their last 7 Sunday games and 2-5 in their last 7 interleague games while the over is 7-3-1 in their last 11 games against the NL West. San Diego is 1-5 in their last 6 home games and 2-6 in their last 8 games against the AL East while the under is 8-1-1 in their last 10 interleague home games.


I’m backing the over here. Michael Wacha and Corey Kluber are two starting pitchers that I simply don’t trust and both have had a tendency to give up hard hit contact and home runs for much of the season. These are two potent offensive lineups 1 through 9, and I think we get a game with some offensive fireworks here. Give me the over.

Chris Ruffolo's Free Pick:Over 8.5
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Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg