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Braves vs Cardinals Prediction 4/21/25 MLB Picks Today

St. Louis Cardinals (9-13) vs. Atlanta Braves (8-13)
April 21, 2025 7:15 pm EDT
The Line: Atlanta Braves -192 / St. Louis Cardinals 160; Over/Under: 8.5
(Get latest betting odds)

In this article, we will formulate a Braves vs Cardinals prediction for this MLB game on Monday, April 21, at Truist Park in Atlanta, Georgia. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (9-13, 1-9 Away) beat the Phillies and Astros at home, but lost the series against the Mets in New York. They suffered a sweep in a four-game series, which was the second time this season the Cardinals were swept. In the latest 7-4 defeat, Thomas Sagesse led the offense with two RBI, while Sonny Gray pitched for 6.0 innings in a no-decision, allowing three runs on six hits with six strikeouts and one walk. Jojo Romero took the loss.

This year, the Cardinals average 4.68 runs per game (8th in the MLB) on a .262/.331/.401 triple-slash. When it comes to pitching, the Cardinals’ staff has a 4.23 ERA (20th) and 1.19 WHIP (9th). Brendan Donovan leads the Cardinals with a .356 batting average, three home runs, and 13 RBI this season.

Erick Fedde will take the mound for the Cardinals on Monday. The 32-year-old right-hander has a 1-2 record in four starts this year with a 3.43 ERA and 1.14 WHIP in 21.0 innings.

Atlanta Braves Betting Preview

The Atlanta Braves (8-13, 6-2 Home) returned home from a couple of series defeats on the road to the Rays and Blue Jays, and responded with a series sweep of the Minnesota Twins. That was Atlanta’s first series sweep of the season. In the most recent 6-2 win, Matt Olson and Drake Baldwin led the team with two RBI apiece, while Grant Holmes got the win after allowing one run on four hits with seven strikeouts and four walks over 5.2 innings of work.

This season, the Braves average 3.67 runs per game (23rd in the MLB) on a .230/.306/.387 slash line. Regarding pitching, the Braves’ staff has a 4.24 ERA (20th) and 1.30 WHIP (20th). Austin Riley leads the Braves with a .264 batting average, five home runs, and 13 RBI this season.

The projected starting pitcher for the Braves is Spencer Schwellenbach, who is 1-1 in four starts this season, with a 2.55 ERA and 0.85 WHIP in 24.2 innings.

Total Runs Facts

  • Four of the Braves’ last five home games against NL Central opponents have gone OVER the total runs line.
  • Four of the Cardinals’ last five games as underdogs against the Braves have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last five night games against NL East opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Braves’ last six games as home favorites against NL Central opponents.

Matchup/League Facts

  • The Braves rank T24th in the league for triples this season (1).
  • The Braves rank 24th in the league for RBIs this season (74).
  • The Cardinals rank 26th in the league for strikeouts this season (158).
  • The Cardinals rank 5th in the league for home runs allowed this season (17).

Braves vs Cardinals Prediction

The Cardinals won six of the previous ten H2H encounters, including three of the last four. Although these two projected starters have been playing well this season, I am going with Over because of their respective records against the opposing batters. Schwellenbach allowed a .400 BA in 30 at-bats against the Cards, while Fedde allowed a .426 BA in 68 at-bats against the Braves. I expect both pitchers to surrender multiple runs in the opening five innings. Go with Over.


Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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