Braves vs Cardinals Prediction 4/22/25 MLB Picks Today

In this article we will formulate a Braves vs Cardinals prediction for this MLB game on Tuesday, April 22nd at Truist Park in Atlanta, Georgia. Let’s take a look at the prediction for this MLB matchup. 

Atlanta Braves Betting Preview

The Atlanta Braves are 9-13 this year after they won game one in this series by a score of 7-6. Atlanta trailed 3-2 in the sixth inning, but they scored five runs in the eighth to escape with the win. The Braves recorded eight hits and they committed two errors in the game, while they were led by Murphy, who went 1-4 with one home run and three RBIs in the win. Atlanta started Schwellenbach, who allowed eight hits and two earned runs over 7.0 innings, while Iglesias allowed three hits and three earned runs in the ninth to nearly blow the lead. 

Prior to this series, the Braves swept the Twins in three games, but lost two out of three against the Blue Jays before that. Atlanta has won four games in a row and they are currently last in the NL East standings. The Atlanta pitching staff has a 4.28 ERA with a 1.31 WHIP and a .242 opponent batting average, while their offense has scored 84 runs with a .232 batting average and a .309 on base percentage this year. Austin Riley has led Atlanta with six home runs and 14 RBIs, while Ozzie Albies has added four home runs and 11 RBIs this year. The projected starting pitcher for Atlanta is TBD. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 9-14 this season after they dropped a heartbreaking game one on Monday night. St. Louis blew a 3-2 lead in the sixth, but they scored three runs in the ninth and came up just short in the loss. The Cardinals recorded 11 hits in the game and they were led by Contreras and Scott II, who both had two RBIs in the loss. St. Louis started Fedde, who allowed five hits and two earned runs over 6.0 innings, while Maton allowed two hits and four earned runs in just 0.1 innings for the loss. 

Prior to this series, the Cardinals lost all four against the Mets, but did win two out of three against the Astros before that. St. Louis has lost five games in a row and they are currently fourth in the NL Central standings. The St. Louis pitching staff has a 4.38 ERA with a 1.21 WHIP and a .232 opponent batting average, while their offense has scored 109 runs with a .264 batting average and a .331 on base percentage this season. Lars Nootbaar has led St. Louis with three home runs, 11 RBIs, and two stolen bases, while Brendan Donovan has added three home runs and 13 RBIs this year. The projected starting pitcher for St. Louis is Andre Pallante, who is 2-1 with a 3.22 ERA and a 1.07 WHIP over 22.1 innings pitched this season. 

Why the Cardinals will beat the Braves

• The Braves have lost eight of their last nine night games against NL Central opponents following a win.
• The Braves have failed to cover the run line in each of their last 12 home games against NL Central opponents.
• The Cardinals have covered the run line in eight of their last nine night games against National League opponents following a road loss.
• The Braves have trailed after 5 innings in four of their last five home games against NL Central opponents that held a losing record.
• The Braves have trailed after 3 innings in seven of their last nine home games against NL Central opponents.

Total Runs Facts

• Five of the Braves’ last six home games against NL Central opponents have gone OVER the total runs line.
• Eight of the Cardinals’ last 10 night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last seven night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the last seven games between the Cardinals and Braves.

Atlanta Braves Player Prop Facts

• Austin Riley has hit a home run in each of his last three appearances against NL Central opponents.
• Ronald Acuna Jr. has recorded at least one RBI in eight of his last nine home appearances against NL Central opponents.
• Alex Verdugo has scored at least one run in each of his last seven appearances against NL opponents at Truist Park.
• Marcell Ozuna has recorded at least one hit in each of the Braves’ last 11 home games against the Cardinals.
• Bryan De La Cruz has recorded at least one Single in each of his last six appearances at Truist Park.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one RBI in six of the Cardinals’ last seven games against the Braves.
• Nolan Gorman has scored at least one run in each of his last seven appearances at Truist Park.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 14 games against opponents that held a losing record.
• Brendan Donovan has recorded at least one Single in each of the Cardinals’ last nine road games against opponents that held a losing record.
• Willson Contreras has hit a home run in each of the Cardinals’ last three games against NL East opponents that held a losing record.
• Brendan Donovan has recorded a Double in three of the Cardinals’ last four night games against opponents that held a losing record.

Matchup/League Facts

• The Braves rank T25th in the league for doubles this season (26).
• The Braves rank T24th in the league for triples this season (1).
• The Cardinals rank 2nd in the league for hits this season (213).
• The Cardinals rank T2nd in the league for doubles this season (46).

Braves vs Cardinals Prediction 

Both of these teams come into this matchup with nine wins on the season, but Atlanta has won four games in a row and has a ton of momentum. The Braves are 7-2 at home this year, while the Cardinals are 1-10 on the road. St. Louis has allowed seven runs in their last two games and they will start Pallante, who has allowed two earned runs in three of his first four starts. Atlanta hasn’t announced their pitching plans for this game, but I like Pallante for the Cardinals and I think he will give them a chance to win. Take St. Louis here.