Cardinals vs Astros Prediction 4/14/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Astros prediction for this MLB game on Monday, April 14th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 7-8 this year after they won two out of three against the Phillies by scores of 2-0, 1-4, and 7-0. In that game three win, the Cardinals were held scoreless through three innings, but they scored seven runs in the last five innings for the shutout win. The Cardinals recorded 10 hits in the game, and they were led by Contreras and Walker, who both had two RBIs in the win. St. Louis started Liberatore, who allowed just three hits over 6.0 innings for the win, while Maton, Romero, and Leahy threw three scoreless innings out of the bullpen. 

Prior to that series, the Cardinals lost two out of three against the Pirates and were swept by the Red Sox in three games. The St. Louis pitching staff has a 4.48 ERA with a 1.20 WHIP and a .226 opponent batting average, while their offense has scored 82 runs with a .280 batting average and a .350 on-base percentage this season. Brendan Donovan has led St. Louis with two home runs and 10 RBIs, while Nolan Arenado has added one home run and seven RBIs this year. The projected starting pitcher for St. Louis is Sonny Gray, who is 2-0 with a 4.50 ERA and a 0.88 WHIP over 16.0 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 7-8 this season after they won two out of three against the Angels by scores of 14-3, 1-4, and 7-3. In the 7-3 win on Sunday, Houston fell behind 2-0 in the second inning, but they scored seven of the last eight runs in the game for the win. The Astros recorded six hits in the game, and they were led by Paredes, who went 1-4 with one home run and three RBIs in the win. Houston started Wesneski, who allowed five hits and three earned runs over 6.0 innings in the win, while King, Abreu, and Hader finished the last three. 

Prior to that series, the Astros lost two out of three games against the Mariners and won two out of three against the Twins. The Houston pitching staff has a 3.69 ERA with a 1.06 WHIP and a .190 opponent batting average, while their offense has scored 60 runs with a .219 batting average and a .309 on-base percentage this season. Isaac Paredes has led Houston with three home runs and nine RBIs, while Jose Altuve has added three home runs and seven RBIs this year. The projected starting pitcher for Houston is Framber Valdez, who is 1-1 with a 2.50 ERA and a 0.94 WHIP over 18.0 innings pitched this season. 

Why the Cardinals will beat the Astros

• The Astros have lost each of their last six games as favorites following a win.
• The Cardinals have won seven of their last eight games as home underdogs.
• The Astros have failed to cover the run line in each of their last seven games against NL Central opponents.
• The Cardinals have covered the run line in nine of their last 10 games as underdogs after playing the previous day.
• The Cardinals have led after 3 innings in each of their last four games against AL West opponents that held a losing record.
• The Astros have trailed after 5 innings in 13 of their last 15 road games against NL Central opponents that held a losing record.

Total Runs Facts

• Each of the Cardinals’ last five night games after playing the previous day have gone OVER the total runs line.
• Each of the Astros’ last four road games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Cardinals’ last 13 night games at Busch Stadium.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Astros’ last nine games as favorites against National League opponents.

St. Louis Cardinals Player Prop Facts

• Sonny Gray has recorded a win in four of his last five home appearances against AL opponents.
• Nolan Arenado has recorded a Double in each of the Cardinals’ last three games against AL opponents that held a losing record.
• Brendan Donovan has recorded at least one Single in each of the Cardinals’ last 10 games against opponents that held a losing record.
• Nolan Gorman has hit at least one home run in three of his last four appearances in night games against AL teams that held a losing record.
• Nolan Arenado has recorded at least one RBI in six of the Cardinals’ last seven home games against AL opponents.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 13 games as underdogs.
• Nolan Arenado has scored at least one run in each of his last six home appearances against AL opponents that held a losing record.
• Sonny Gray has recorded seven or more strikeouts in five of his last six appearances against opponents that held a losing record.

Houston Astros Player Prop Facts

• Framber Valdez has recorded a win in six of his last seven appearances with the Astros as favorites against NL opponents.
• Brendan Rodgers has recorded a Double in three of his last four appearances with his team as a favorite against NL Central opponents.
• Jose Altuve has recorded at least one Single in each of the Astros’ last 10 games as favorites against NL opponents.
• Isaac Paredes has hit a home run in each of the Astros’ last three games as favorites.
• Yainer Diaz has recorded at least one RBI in each of the Astros’ last four games as favorites against the Cardinals.
• Jose Altuve has recorded at least one hit in each of the Astros’ last 10 games as favorites against NL opponents.
• Jose Altuve has scored at least one run in each of his last six road appearances against the Cardinals after playing the previous day.
• Framber Valdez has recorded seven or more strikeouts in five of his last six appearances with the Astros as favorites against NL opponents.

Matchup/League Facts

• The Cardinals rank 1st in the league for on-base percentage this season (.350).
• The Cardinals rank 2nd in the league for hits this season (152).
• The Astros rank 30th in the league for doubles this season (12).
• The Astros rank 1st in the league for strikeouts this season (166).

Cardinals vs Astros Prediction 

Both of these teams come into this series with a 7-8 record through 15 games, and each team is coming off of a series win. St. Louis did a better job of pitching against the Phillies, but they have struggled in that department this year. Houston has scored at least six runs in three of their last four games, so it will be interesting to see if they can capitalize against this St. Louis pitching staff. Both of these pitchers are very good, but I have to give the advantage to St. Louis and their high-scoring offense. Take the Cardinals here.