Cardinals vs Guardians Prediction 4/13/26 MLB Picks Today

The Cleveland Guardians and St. Louis Cardinals meet Monday in MLB action at Busch Stadium. Here’s a Cardinals vs. Guardians Prediction. This article will include a Cardinals vs. Guardians Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 9-7 on the year and play the Orioles and Astros next. The Cleveland Guardians are batting. 222 on the season, have a .311 OBP, and have a .370 slugging percentage. The Cleveland Guardians pitching staff has a 4.05 ERA and a 1.28 WHIP. Chase DeLauter leads the Cleveland Guardians with 15 hits and 12 RBI while Steven Kwan and Angel Martinez have combined for 27 hits and 10 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 1-1 with a 2.04 ERA and 25 strikeouts this season. This will be Williams’ second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 8-7 on the year and play the Marlins and Astros next. The St. Louis Cardinals are batting .224 on the season and have a .320 OBP, and a .356 slugging percentage. The St. Louis Cardinals pitching staff has a 5.10 ERA and a 1.48 WHIP. Jordan Walker leads the St. Louis Cardinals with 18 hits and 14 RBI while Alec Burleson and JJ Wetherholt have combined for 26 hits and 16 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-0 with a 3.38 ERA and 10 strikeouts this season. Liberatore is 1-1 with a 3.09 ERA and 8 strikeouts in his career against the Cleveland Guardians.

Why the St. Louis Cardinals will win

• The Guardians have lost each of their last eight night games against NL Central opponents.
• The Cardinals have won six of their last seven games as underdogs against AL Central opponents following a loss.
• The Guardians have failed to cover the run line in seven of their last eight games as favorites.
• The Cardinals have covered the run line in six of their last seven games as underdogs against AL Central opponents following a loss.
• The Cardinals have led after 3 innings in each of their last three games against the Guardians.
• The Guardians have trailed after 5 innings in five of their last six night games against NL Central opponents.

Why the Cleveland Guardians will win

• The Guardians have won each of their last nine games following a loss.
• The Cardinals have lost each of their last seven home games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last eight road games against National League opponents following a loss.
• The Cardinals have failed to cover the run line in nine of their last 10 home games against American League opponents that held a winning record.
• The Cardinals have lost the first inning in four of their last five home games against AL Central opponents.
• The Cardinals have trailed after 5 innings in 10 of their last 11 home games against American League opponents that held a winning record.

Total Runs Facts

• Six of the Cardinals’ last seven games as underdogs against the Guardians have gone OVER the total runs line.
• Five of the Guardians’ last six road games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last eight road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six night games between the Guardians and Cardinals.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in two of the Cardinals’ last three night games against AL Central opponents that held a winning record.
• Lars Nootbaar has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.
• Jordan Walker ranks 1st in the league in Home Runs (7) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of the Guardians’ last two games as road favorites against the Cardinals.
• Steven Kwan has recorded two hits in each of the Guardians’ last three games as favorites against NL opponents.
• Chase DeLauter ranks T4th in the league in Home Runs (5) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (91).
• The Cardinals rank 30th in the league for opponent batting average this season (.266).
• The Guardians rank 2nd in the league for strikeouts this season (160).
• The Guardians rank T4th in the league for doubles this season (31).

Cardinals vs Guardians Prediction

The Guardians’ pitching staff got rocked in Atlanta and now they have to travel after playing Sunday night. The Cardinals didn’t have to travel yesterday so there’s a rest advantage for the home team. I’d consider the under with the way Williams and Liberatore have looked through a couple of starts, but I’m going to side with the Cardinals if forced to pick a side. The Guardians’ pitching is coming off a rough weekend and now has a tough travel spot. Give me the Cards at home and the cheap price.