Cardinals vs Guardians Prediction 4/14/26 MLB Picks Today

In this article we will formulate a Cardinals vs Guardians prediction for this MLB game on Tuesday, April 14th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 8-8 this season after they lost game one in this series by a score of 9-3 on Monday. St. Louis tied the game at one in the first inning, but they allowed the next five runs and never recovered in the loss. The Cardinals recorded nine hits and they committed one error in the game, while they were led by Burleson, Walker, and Pages, who all had one RBI. Liberatore allowed six hits and four earned runs over 5.0 innings for the loss, while Bruihl allowed two earned runs in relief. Prior to this series, St. Louis lost two out of three against the Red Sox, but won two out of three against the Nationals before that. 

This season, St. Louis has a 5.15 ERA with a 1.50 WHIP and a .268 opponent batting average, while they have scored 69 runs with a .226 batting average and a .320 on base percentage. Jordan Walker has led the Cardinals with eight home runs and 15 RBIs, while Alec Burleson has added two home runs and 12 RBIs. The projected starting pitcher for St. Louis is Michael McGreevy, who is 1-1 with a 2.16 ERA and a 0.78 WHIP over 16.2 innings pitched this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 10-7 this year after they won game one by a score of 9-3 last night. Cleveland scored three runs in the fourth inning and two in the sixth to break the game open, before adding three more in the eighth in the win. The Guardians recorded 11 hits in the game and they were led by Rocchio, Schneemann, and Kwan, who all had two RBIs. Williams allowed five hits and two earned runs over 5.0 innings for the win, while Gaddis allowed one earned run in relief. Prior to this series, Cleveland lost two out of three against the Braves, but did win two out of three against the Royals before that. 

This season, Cleveland has a 3.99 ERA with a 1.29 WHIP and a .232 opponent batting average, while they have scored 67 runs with a .227 batting average and a .316 on base percentage. Chase DeLauter has led the Guardians with five home runs and 12 RBIs, while Jose Ramirez has added two home runs and seven RBIs. The projected starting pitcher for Cleveland is Joey Cantillo, who is 1-0 with a 2.45 ERA and a 1.23 WHIP over 14.2 innings pitched this year. 

Why the St. Louis Cardinals will win

• The Guardians have lost each of their last five games as road favorites against NL Central opponents following a win.
• The Cardinals have won six of their last eight games as underdogs against AL Central opponents following a loss.
• The Guardians have failed to cover the run line in each of their last six road games following a win.
• The Cardinals have covered the run line in each of their last six Tuesday games as home underdogs.
• The Cardinals have led after 5 innings in three of their last four night games against AL Central opponents.
• The Cardinals have led after 3 innings in three of their last four games against the Guardians.

Why the Cleveland Guardians will win

• The Cardinals have lost each of their last eight home games against American League opponents that held a winning record.
• The road team has won each of the last four games between the Guardians and Cardinals.
• The Cardinals have failed to cover the run line each of their last six games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last six games against NL Central opponents.
• The Guardians have won the first inning in each of their last five Tuesday night games as favorites.
• The Guardians have led after 3 innings in each of their last five Tuesday night games as favorites.
• The Cardinals have trailed after 5 innings in each of their last six home games against AL Central opponents.

Total Runs Facts

• Seven of the Cardinals’ last eight games as underdogs against the Guardians have gone OVER the total runs line.
• Four of the Guardians’ last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six games as home underdogs against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine road games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in four of his last 12 appearances against AL Central opponents.
• Lars Nootbaar has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.
• Jordan Walker ranks 1st in the league in Home Runs (8) this season.

Cleveland Guardians Player Prop Facts

• Brayan Rocchio has hit a home run in four of the Guardians’ last six games as favorites.
• Steven Kwan has recorded two hits in each of the Guardians’ last four games as favorites against NL opponents.
• Jose Ramirez ranks T2nd in the league in Steals (7) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (97).
• The Cardinals rank 29th in the league for opponent batting average this season (.268).
• The Guardians rank 2nd in the league for strikeouts this season (166).
• The Guardians rank T4th in the league for doubles this season (32).

Cardinals vs Guardians Prediction

St. Louis comes into this matchup on a three game losing streak and they have allowed 7+ runs in all three of those losses. The Cardinals are 5-5 at home this year, while the Guardians are 6-5 on the road. Cleveland has alternated wins and losses over their last five games, but they have scored 6+ in all three of those wins. The Guardians are starting Cantillo, who has allowed two earned runs or fewer in all three starts. The Cardinals are going with McGreevy, who has allowed four earned runs and 11 hits over 16.2 innings. I like this pitching matchup and I think runs are going to be hard to find, so I like the under here.