Cardinals vs Mariners Prediction 9/8/25 MLB Picks Today

In this article, we will formulate a Reds vs Padres Prediction for this MLB game on Monday, September 8^th at the T-Mobile Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 75-68 record this season and are sitting on the second place of the AL West. The Mariners have a 41-27 home record and are 78-59 in over/under. They are coming off a 18-2 road victory over the Braves, and have back-to-back wins. Over is 5-1 in their last 6 games and are playing the Angels and the Royals next.

The Mariners have a .243 batting average this season, .319 OBP and .416 Slugging percentage. Seattle’s pitching staff has a 4.01 ERA and 1.26 WHIP. Julio Rodriguez leads the Mariners in hits with 156, and he is the team’s best hitter with a .267 batting average. Cal Raleigh leads the team both in RBI with 113, and in home runs with 53.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 12-7 record, 3.02 ERA and 0.97 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-72 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 31-38 road record and are 72-64 in over/under. They are coming off a 4-3 home victory over the Giants, and are 4-1 in their last 5 games. Under is 4-1 in their last 5 games and are playing the Brewers and the Reds next.

The Cardinals have a .246 batting average this season, .315 OBP and .381 Slugging percentage. Saint Louis’ pitching staff has a 4.27 ERA and 1.31 WHIP. Masyn Winn leads the Cardinals with 124 hits, while Alec Burleson is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 7-10 record, 4.89 ERA and 1.33 WHIP.

St. Louis Cardinals @ Seattle Mariners Betting Trends: September 8, 2025

• Probable Starting Pitcher: Bryan Woo      Record this season: 12-7      ERA: 3.02
• Home Record: 8-2
• Last 5 against Cardinals: –

Why the Seattle Mariners will win

• The Cardinals have lost each of their last six night games against the Mariners following a win.
• The Mariners have won 11 of their last 13 home games.
• The Cardinals have failed to cover the run line in each of their last eight games against the Mariners following a win.
• The Mariners have covered the run line in five of their last six night games against NL Central opponents following a road win.
• The Cardinals have lost the first inning in seven of their last eight night games against American League opponents that held a winning record.
• The Cardinals have trailed after 3 innings in three of their last four road games against opponents that held a winning record.
• The Cardinals have trailed after 5 innings in seven of their last eight night games against American League opponents that held a winning record.

• Probable Starting Pitcher: Miles Mikolas      Record this season: 7-10      ERA: 4.89
• Road Record: 3-6
• Last 5 against Mariners: 1-1

Why the St. Louis Cardinals will win

• The Mariners have lost six of their last seven games as favorites following a road win.
• The Cardinals have won five of their last six games as underdogs.
• The underdogs have covered the run line in each of the Cardinals’ last six games.
• The Mariners have failed to cover the run line in nine of their last 10 home games against National League opponents following a win.
• The Mariners have lost the first inning in three of their last four night games.
• The Mariners have trailed after 3 innings in six of their last seven night games against National League opponents.
• The Cardinals have led after 5 innings in three of their last four road night games.

Total Runs Facts

• Seven of the Mariners’ last eight home games against NL Central opponents have gone UNDER the total runs line.
• Each of the Cardinals’ last four games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Mariners’ last eight home games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last four games against American League opponents.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit at least one home run in three of the Mariners’ last four night games.
• Randy Arozarena has recorded at least one hit in each of his last nine home appearances against former teams.
• Jorge Polanco has recorded a Double in three of the Mariners’ last four home games against NL opponents.
• Cal Raleigh ranks 1st in the league in Home Runs (53) this season.

St. Louis Cardinals Player Prop Facts

• Miles Mikolas has recorded four or more strikeouts in four of his last five road appearances against opponents that held a winning record.
• Willson Contreras has recorded at least one hit in each of his last 10 appearances against AL opponents that held a winning record.
• Alec Burleson has hit a home run in each of the Cardinals’ last two road games against AL opponents that held a winning record.
• Victor Scott II ranks 10th in the league in Steals (31) this season.

Matchup/League Facts

• The Mariners rank 30th in the league for doubles this season (193).
• The Mariners rank 2nd in the league for home runs this season (210).
• The Cardinals rank 30th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1066).

Cardinals vs Mariners Prediction

Both teams are tied 5-5 wins in their last 10 head-to-head meetings, but the Cardinals are 3-2 in their last 5 meetings in Seattle. Over is 3-1-1 in their last 5 meetings.

In this Cardinals vs Mariners Prediction, the Mariners are coming as -225 home favorites. The Mariners are likely to win, but I won’t lay -225 on the moneyline, when the Cardinals are playing good baseball lately. Mikolas is coming off back-to-back quality starts with one earned run in each game, while Woo has 5 earned runs in his last two starts. On top of that, the Cardinals have a better bullpen, and have been historically competitive against the Mariners, so I like them to keep this one close. Take the Saint Louis Cardinals by +1.5 runs in this one.