Cardinals vs Mariners Prediction 9/10/25 MLB Picks Today

In this article, we will formulate a Reds vs Padres Prediction for this MLB game on Wednesday, September 10^th at the T-Mobile Park in the third game of this series, with the Mariners having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 77-68 record this season and are sitting on the second place of the AL West. The Mariners have a 43-27 home record and are 79-60 in over/under. They are coming off a 5-3 home victory over the Cardinals, and have four consecutive wins. Over is 6-2 in their last 8 games and are playing the Angels and the Royals next.

The Mariners have a .243 batting average this season, .320 OBP and .416 Slugging percentage. Seattle’s pitching staff has a 3.99 ERA and 1.25 WHIP. Julio Rodriguez leads the Mariners in hits with 158, and he is the team’s best hitter with a .266 batting average. Cal Raleigh leads the team both in RBI with 113, and in home runs with 53.

Logan Gilbert (R) is the projected starting pitcher for the Mariners, and he has a 4-6 record, 3.61 ERA and 1.02 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-74 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 31-40 road record and are 73-65 in over/under. They are coming off a 3-5 road defeat by the Mariners, and have back-to-back losses. Under is 5-2 in their last 7 games and are playing the Brewers and the Reds next.

The Cardinals have a .245 batting average this season, .314 OBP and .380 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 125 hits, and he is the team’s best hitter with a .285 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 6-3 record, 4.68 ERA and 1.26 WHIP.

St. Louis Cardinals @ Seattle Mariners Betting Trends: September 10, 2025

• Probable Starting Pitcher: Logan Gilbert      Record this season: 4-6      ERA: 3.61
• Home Record: 3-2
• Last 5 against Cardinals: 0-1

Why the Seattle Mariners will win

• The Mariners have won 12 of their last 13 home games against teams that held a losing record.
• The Cardinals have lost nine of their last 10 games against American League opponents that held a winning record.
• The Cardinals have failed to cover the run line in seven of their last eight night games against AL West opponents that held a winning record.
• The Mariners have covered the run line in each of their last four games.
• The Mariners have led after 5 innings in five of their last six home games.
• The Mariners have led after 3 innings in each of their last three games against opponents that held a losing record.

• Probable Starting Pitcher: Michael McGreevy      Record this season: 6-3      ERA: 4.68
• Road Record: 4-0
• Last 5 against Mariners: –

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last 11 Wednesday games as underdogs against American League opponents.
• The Mariners have lost five of their last six Wednesday games as home favorites against NL Central opponents.
• The Cardinals have covered the run line in each of their last 11 Wednesday games as underdogs against American League opponents.
• The Mariners have failed to cover the run line in eight of their last 10 games as favorites against National League opponents following a home win.
• The Cardinals have led after 5 innings in three of their last four games at T-Mobile Park.

Total Runs Facts

• Six of the Mariners’ last seven games after playing the previous day have gone OVER the total runs line.
• Five of the Cardinals’ last six games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last seven games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six games against American League opponents.

Seattle Mariners Player Prop Facts

• Jorge Polanco has recorded a Double in five of the Mariners’ last six home games against NL opponents.
• Randy Arozarena has hit a home run in three of the Mariners’ last four home games against NL opponents that held a losing record.
• Randy Arozarena has recorded at least one hit in each of his last 11 home appearances against former teams.
• Logan Gilbert has recorded a win in four of his last five appearances with the Mariners as favorites against NL Central opponents.
• Cal Raleigh ranks 1st in the league in Home Runs (53) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in three of the Cardinals’ last four road games against AL opponents that held a winning record.
• Alec Burleson has recorded at least one hit in each of his last 11 road appearances against AL opponents.
• Victor Scott II ranks 10th in the league in Steals (32) this season.

Matchup/League Facts

• The Mariners rank 30th in the league for doubles this season (197).
• The Mariners rank 29th in the league for triples this season (8).
• The Cardinals rank 30th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1075).

Cardinals vs Mariners Prediction

The Mariners are 6-2 in their last 8 head-to-head meetings against the Cardinals, and are 4-1 in their last 5 meetings in Seattle. Over is 3-1 in their last 4 meetings in Seattle.

In this Cardinals vs Mariners Prediction, the Mariners are coming as -230 home favorites. The Mariners have won by 2 runs each of the first two games of this series, and now have Logan Gilbert on the mound, who has been excellent at home, with a 2.15 home ERA. He has just one earned run in each of his last two home starts, while on the flip side, McGreevy has 4+ runs in two of his last three starts for the Cardinals. The Mariners have a better offense to offer Gilbert run support, so I expect them to win by 2+ runs in this one as well.