Cardinals vs Reds Prediction 6/21/25 MLB Picks Today

The Cincinnati Reds and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Cardinals vs Reds Prediction. This article will include a Cardinals vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 39-37 on the year and play the Yankees, Padres, and Red Sox next. The Cincinnati Reds are batting .247 on the season, have a .321 OBP, and a .401 slugging percentage. The Cincinnati Reds pitching staff has a 3.90 ERA and a 1.23 WHIP. TJ Friedl leads the Cincinnati Reds with 80 hits and 29 RBI, while Elly De La Cruz and Gavin Lux have combined for 136 hits and 81 RBI.

Brent Suter gets the ball for the Cincinnati Reds, and he is 1-0 with a 2.91 ERA and 21 strikeouts this season. Suter is 2-2 with a 3.34 ERA and 54 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 41-35 on the year and play the Cubs, Guardians, and Pirates next. The St. Louis Cardinals are batting .257 on the season, have a .329 OBP, and a .395 slugging percentage. The St. Louis Cardinals pitching staff has a 3.94 ERA and a 1.27 WHIP. Brendan Donovan leads the St. Louis Cardinals with 83 hits and 27 RBI while Alec Burleson and Willson Contreras have combined for 133 hits and 77 RBI.

Sonny Gray gets the ball for the St. Louis Cardinals, and he is 7-2 with a 3.84 ERA and 85 strikeouts this season. Gray is 1-3 with a 4.70 ERA and 28 strikeouts in his career against the Cincinnati Reds.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last eight games as home favorites against National League opponents.
• The Reds have lost five of their last six games against NL Central opponents that held a winning record.
• The Cardinals have covered the run line in seven of their last eight games against NL Central opponents.
• The Reds have failed to cover the run line in each of their last five road games against National League opponents after playing the previous day.
• The Cardinals have led after 5 innings in four of their last five day games against the Reds at Busch Stadium.
• The Reds have trailed after 3 innings in seven of their last eight games against National League opponents.

Why the Cincinnati Reds will win

• The Cardinals have lost five of their last six games as favorites against the Reds following a home win.
• The Reds have won four of their last five games as underdogs after playing the previous day.
• The Cardinals have failed to cover the run line in 12 of their last 13 Saturday games as favorites against NL Central opponents.
• The Reds have covered the run line in six of their last seven games as road underdogs against National League opponents following a road loss.
• The Cardinals have trailed after 5 innings in four of their last five home games.

St. Louis Cardinals Player Prop Facts

• Sonny Gray has recorded eight or more strikeouts in three of his last four home appearances against NL Central opponents.
• Sonny Gray has recorded a win in three of his last four home appearances.
• Willson Contreras has recorded at least one RBI in each of his last eight appearances with the Cardinals as home favorites.
• Masyn Winn has recorded at least one Double in each of his last three appearances with the Cardinals as home favorites against NL Central opponents.
• Willson Contreras has recorded at least one hit in 17 of his last 18 home appearances against opponents that held a winning record.
• Willson Contreras has hit a home run in two of his last three appearances with the Cardinals as home favorites against NL opponents.
• Masyn Winn has scored a run in each of the Cardinals’ last four home games.
• Victor Scott II ranks T5th in the league in Steals (21) this season.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has hit a home run in four of the Reds’ last five road games against opponents that held a winning record.
• Tyler Stephenson has recorded at least one RBI in each of his last four appearances in day games.
• Jose Trevino has recorded a Double in four of his last five road appearances after playing the previous day.
• Jose Trevino has recorded at least one hit in each of his last 10 appearances after playing the previous day.
• Jose Trevino has scored at least one run in each of his last five road appearances after playing the previous day.
• Elly De La Cruz ranks T5th in the league in Steals (21) this season.

Cardinals vs Reds Prediction

Not a fan of bullpen games and, Suter hasn’t pitched well this month, allowing eight hits and three runs in his last 5.2 innings. The Reds are rolling this week and Gray has been fabulous this season with a 3.84 ERA and 1.18 WHIP. In 53.2 home innings, Gray has a 2.85 ERA and .245 allowed batting average with 57 strikeouts. The Reds are in good form right now and there’s a head and shoulders edge on the mound. I’ll side with the Reds and take the RL to shave down the price.