Cardinals vs Reds Prediction 6/22/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Reds prediction for this MLB game on Sunday, June 22, at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Betting Preview

The Cincinnati Reds (39-38, 19-21 Away) won four straight series after defeating the Diamondbacks, Guardians, Tigers, and Twins, but are on a three-game losing skid at the moment following losses to the Twins and Cardinals. Cincinnati opened the series against the Cards with two defeats, including last night’s 6-5 in extra innings. Elly De La Cruz led the offense with two RBI, while Brent Suter pitched for 2.0 innings in a no-decision, allowing two runs on two hits with two strikeouts and one walk. Chase Petty took the loss.

This season, the Reds average 4.62 runs per game (10th in the MLB) on a .247/.321/.402 triple-slash. When it comes to pitching, the Reds’ staff has a 3.91 ERA (16th) and 1.22 WHIP (10th). Elly De La Cruz leads the Reds with a .265 batting average, 17 home runs, and 52 RBI this season.

Andrew Abbott will take the mound for the Reds on Sunday. The 26-year-old left-hander has a 6-1 record in 12 starts this year with a 1.84 ERA and 1.01 WHIP in 68.1 innings.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (42-35, 24-14 Home) are on a five-game winning streak after sweeping the Chicago White Sox in three games and beating the Reds in the opening two of the current series. In Saturday’s 6-5 extra-inning victory, Alec Burleson led the offense with three RBI, while Sonny Gray pitched for 5.0 innings in a no-decision, allowing one run on five hits with five strikeouts and two walks. Phil Maton was credited with the win.

This year, the Cardinals average 4.74 runs per game (8th in the MLB) on a .256/.329/.395 triple-slash. When it comes to pitching, the Cardinals’ staff has a 3.94 ERA (20th) and 1.26 WHIP (16th). Willson Contreras leads the Cardinals with a .244 batting average, ten home runs, and 50 RBI this season.

The projected starting pitcher for the Cardinals is Miles Mikolas, who is 4-4 in 14 starts this season, with a 4.35 ERA and 1.30 WHIP in 72.1 innings.

Why the Reds will beat the Cardinals

• The favorites have won seven of the Cardinals’ last eight games.
• The Reds have covered the run line in six of their last seven day games following a loss.
• The Cardinals have failed to cover the run line in five of their last six home games against teams that held a winning record.

Total Runs Facts

• Seven of the Reds’ last eight games as road favorites have gone UNDER the total runs line.
• Five of the last six games between the Reds and Cardinals at Busch Stadium have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven games as home underdogs against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Reds’ last 12 games as favorites against National League opponents.

Matchup/League Facts

• The Cardinals rank 3rd in the league for batting average this season (.256).
• The Cardinals rank 28th in the league for strikeouts this season (559).
• The Reds rank 8th in the league for hits allowed this season (595).
• The Reds rank 9th in the league for doubles this season (128).

Cardinals vs Reds Prediction

The Cardinals won six of the previous ten H2H encounters, including four out of six this season. I am going with the Reds here because of Andrew Abbott, who has been phenomenal this year. He had a complete-game shutout two starts ago, and allowed more than a run in a game just once in his last nine starts! Abbot surrendered no earned runs in 4.0 innings against the Cardinals earlier in the season, while he allowed a .218 BA in 78 at-bats against the Cards in his career. Miles Mikolas, on the other hand, was also great against Cincinnati this season, allowing no runs in 5.0 innings, but he allowed multiple runs in each of his previous four starts. Go with Cincy.