Cardinals vs Reds Prediction 9/16/25 MLB Picks Today

The Cincinnati Reds and St. Louis Cardinals meet Tuesday in MLB action at Busch Stadium. Here’s a Cardinals vs Reds Prediction. This article will include a Cardinals vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 75-75 on the year and play the Cubs, Pirates, and Brewers next. The Cincinnati Reds are batting .246 on the season, have a .317 OBP, and a .392 slugging percentage. The Cincinnati Reds pitching staff has a 3.99 ERA and a 1.24 WHIP. Elly De La Cruz leads the Cincinnati Reds with 155 hits and 82 RBI, while TJ Friedl and Spencer Steer have combined for 252 hits and 112 RBI.

Andrew Abbott gets the ball for the Cincinnati Reds, and he is 9-6 with a 2.79 ERA and 136 strikeouts this season. Abbott is 4-3 with a 3.74 ERA and 31 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 73-78 on the year and play the Brewers, Giants, and Cubs next. The St. Louis Cardinals are batting .245 on the season, have a .314 OBP, and a .378 slugging percentage. The St. Louis Cardinals pitching staff has a 4.32 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 129 hits and 65 RBI while Willson Contreras and Masyn Winn have combined for 250 hits and 131 RBI.

Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 6-3 with a 4.44 ERA and 47 strikeouts this season. This will be McGreevy’s second career game against the Cincinnati Reds.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: September 16, 2025

• Probable Starting Pitcher: Michael McGreevy      Record this season: 6-3      ERA: 4.44
• Home Record: 2-3
• Last 5 against Reds: 1-0

Why the St. Louis Cardinals will win

• The Reds have lost each of their last six games as road favorites against NL Central opponents following a road win.
• The underdogs have won six of the Cardinals’ last seven games at Busch Stadium.
• The underdogs have covered the run line in each of the Cardinals’ last seven games at Busch Stadium.
• The Reds have failed to cover the run line in each of their last nine Tuesday games as road favorites against NL Central opponents.
• The Reds have trailed after 3 innings in three of their last four road games against National League opponents that held a losing record.
• The Reds have lost the first inning in three of their last four road games against National League opponents that held a losing record.
• The Cardinals have led after 5 innings in four of their last five night games against the Reds.

• Probable Starting Pitcher: Andrew Abbott      Record this season: 9-6      ERA: 2.79
• Road Record: 5-2
• Last 5 against Cardinals: 3-1

Why the Cincinnati Reds will win

• The Cardinals have lost each of their last five night games after playing the previous day.
• The Reds have won five of their last six games against National League opponents.
• The Cardinals have failed to cover the run line in each of their last seven night games against the Reds following a loss.
• The Reds have covered the run line in each of their last six night games against National League opponents.
• The Reds have led after 3 innings in four of their last five road games against National League opponents.
• The Reds have won the first inning in three of their last four games as favorites against the Cardinals.
• The Cardinals have trailed after 5 innings in four of their last five home night games.

Total Runs Facts

• Each of the Reds’ last four games as road favorites have gone OVER the total runs line.
• Four of the Cardinals’ last five games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Reds’ last eight road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five night games between the Reds and Cardinals at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in two of his last three appearances with the Cardinals as home underdogs against the Reds.
• Nolan Arenado has recorded at least one hit in 12 of his last 13 home appearances against the Reds.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has recorded a Double in four of the Reds’ last five games against the Cardinals.
• Austin Hays has recorded at least one hit in each of the Reds’ last 10 night games.
• Will Benson has hit a home run in each of the Reds’ last two games as favorites.
• Elly De La Cruz ranks T7th in the league in Steals (35) this season.

Matchup/League Facts

• The Cardinals rank T29th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1117).
• The Reds rank T8th in the league for hits allowed this season (1186).
• The Reds rank 22nd in the league for home runs this season (152).

Cardinals vs Reds Prediction

Neither the Cardinals nor Reds have much to play for in these final couple of weeks, so motivation will be key. Abbott has had games where he’s been tagged, but he’s still been strong overall with his 2.79 ERA and 1.13 WHIP, and that gives the Reds the edge on Tuesday. McGreevy has been far more hittable this season, especially at home where he has a 6.07 ERA and .301 allowed batting average in 43 innings. McGreevy has allowed 12 runs in his last 22 innings overall. Give me the Reds.