Cardinals vs White Sox Prediction 9/11/26 MLB Picks Today
Chicago White Sox (75-71) vs. St. Louis Cardinals (72-75)
September 11, 2026 8:15 pm EDT
The Line: St. Louis Cardinals -107 / Chicago White Sox -112; Over/Under: 8.5
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In this article we will formulate a Cardinals vs White Sox prediction for this MLB game on Friday, September 11th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 72-75 this year after they lost all three against the Giants by scores of 4-5, 1-2, and 6-7. In game three, St. Louis led 6-1 in the eighth inning, but they allowed six runs in the bottom of the eighth for the loss. The Cardinals recorded eight hits in the game and they were led by Bernal, who went 1-4 with one home run and three RBIs. Pallante allowed five hits and one earned run over 5.0 innings, while Soriano blew the save and picked up the loss. Prior to that series, St. Louis won two out of three against the Rockies and two out of three against the Dodgers.
This season, St. Louis has a 4.31 ERA with a 1.35 WHIP and a .255 opponent batting average, while they have scored 668 runs with a .243 batting average and a .317 on base percentage. Jordan Walker has led the Cardinals with 28 home runs and 100 RBIs, while Alec Burleson has added 22 home runs and 104 RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 5-14 with a 5.57 ERA and a 1.47 WHIP over 139.0 innings pitched this year.
Chicago White Sox Betting Preview
The Chicago White Sox are 75-71 this season after they lost all three against the Pirates by scores of 3-9, 2-4, and 0-2. In game three, Chicago allowed a run in the fourth inning and another in the eighth in the low scoring loss. The White Sox recorded two hits and they were led by Grichuk, who went 1-1 in the game. Smith opened the game, while Fedde allowed two earned runs for the loss. Prior to that series, Chicago won two out of three against the Twins, but lost three out of four against the Astros before that.
This season, Chicago has a 4.13 ERA with a 1.31 WHIP and a .241 opponent batting average, while they have scored 685 runs with a .235 batting average and a .317 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 83 RBIs, while Miguel Vargas has added 30 home runs and 79 RBIs. The projected starting pitcher for Chicago is Anthony Kay, who is 9-8 with a 4.47 ERA and a 1.36 WHIP over 141.0 innings pitched this season.
Why the St. Louis Cardinals will win
- The White Sox have lost each of their last four games as favorites against NL Central opponents.
- The underdogs have won four of the White Sox’s last five games.
- The underdogs have covered the run line in each of the Cardinals’ last nine games at Busch Stadium.
- The White Sox have failed to cover the run line in each of their last five games against NL opponents.
- The Cardinals have won the first inning in four of their last five games against AL Central opponents.
- The Cardinals have led after 3 innings in five of their last six night games against the White Sox at Busch Stadium.
- The White Sox have trailed after 5 innings in each of their last five night games against NL opponents.
Why the Chicago White Sox will win
- The road team has won seven of the last eight games between the White Sox and Cardinals.
- The Cardinals have lost eight of their last nine night games against AL opponents following a loss.
- The White Sox have covered the run line in nine of their last 10 road games against NL Central opponents that held a losing record.
- The Cardinals have failed to cover the run line in seven of their last eight games following a road loss.
- The Cardinals have lost the first inning in each of their last four games.
- The White Sox have led after 3 innings in five of their last six games as road favorites against NL Central opponents.
- The White Sox have led after 5 innings in four of their last five games as road favorites.
Total Runs Facts
- Each of the Cardinals’ last six night games against AL Central opponents have gone OVER the total runs line.
- Seven of the White Sox’s last eight road games after playing the previous day have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the White Sox’s last six games as road favorites.
- There has been at least one run scored in the first inning in eight of the Cardinals’ last nine home games against AL Central opponents.
St. Louis Cardinals Player Prop Facts
- Alec Burleson has hit a home run in two of the Cardinals’ last three games against the White Sox.
- Matthew Liberatore has recorded six or more strikeouts in each of his last four appearances with the Cardinals as underdogs.
- Nathan Church has recorded at least one hit in each of the Cardinals’ last nine games.
- Jordan Walker ranks T8th in the league in Hits (157) this season.
Chicago White Sox Player Prop Facts
- Brenton Doyle has hit a home run in three of his last four appearances in night games against NL Central teams that held a losing record.
- Anthony Kay has recorded four or more strikeouts in each of his last four appearances against NL opponents.
- Miguel Vargas has recorded at least one hit in each of the White Sox’s last 15 road games against NL opponents.
- Colson Montgomery ranks T10th in the league in Home Runs (31) this season.
Matchup/League Facts
- The Cardinals rank T3rd in the league for home runs allowed this season (146).
- The Cardinals rank 26th in the league for slugging percentage this season (.385).
- The White Sox rank 26th in the league for batting average this season (.235).
- The White Sox rank 6th in the league for home runs this season (190).
Cardinals vs White Sox Prediction
St. Louis comes into this matchup after getting swept by the Giants and they had a horrible collapse in game three. The Cardinals are 34-38 at home this year, while the White Sox are 32-40 on the road. Chicago was also swept in their last series by the Pirates and they scored just five runs in those three games. The Sox are starting Kay, who has allowed 4+ earned runs in three straight starts, while Liberatore has allowed 5, 3, 8, and 3 earned runs in his last four starts. Take the over here.