Cardinals vs Yankees Prediction 8/16/25 MLB Picks Today
NY Yankees (65-57) vs. St. Louis Cardinals (61-62)
August 16, 2025 7:15 pm EDT
The Line: St. Louis Cardinals 118 / NY Yankees -144; Over/Under: 8
(Get latest betting odds)
The New York Yankees and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Cardinals vs Yankees Prediction. This article will include a Cardinals vs Yankees Pick.
New York Yankees Betting Preview
The New York Yankees are 65-57 on the year and play the Rays, Red Sox, and Nationals next. The New York Yankees are batting .249 on the season, have a .329 OBP, and a .445 slugging percentage. The New York Yankees pitching staff has a 4.01 ERA and a 1.25 WHIP. Aaron Judge leads the New York Yankees with 134 hits and 89 RBI while Cody Bellinger and Paul Goldschmidt have combined for 227 hits and 109 RBI.
Max Fried gets the ball for the New York Yankees, and he is 12-5 with a 2.94 ERA and 135 strikeouts this season. Fried is 5-0 with a 1.10 ERA and 33 strikeouts in his career against the St. Louis Cardinals.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 61-62 on the year and play the Marlins, Rays, and Pirates next. The St. Louis Cardinals are batting .249 on the season, have a .318 OBP, and a .386 slugging percentage. The St. Louis Cardinals pitching staff has a 4.18 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 118 hits and 45 RBI, while Masyn Winn and Alec Burleson have combined for 218 hits and 97 RBI.
Sonny Gray gets the ball for the St. Louis Cardinals, and he is 11-5 with a 4.06 ERA and 148 strikeouts this season. Gray is 2-2 with a 3.38 ERA and 41 strikeouts in his career against the New York Yankees.
Why the St. Louis Cardinals will win
- The Yankees have lost each of their last five games as road favorites following a win.
- The Cardinals have won five of their last six games as home underdogs against American League opponents following a loss.
- The Yankees have failed to cover the run line in each of their last eight road games.
- The Cardinals have covered the run line in each of their last six games as underdogs against American League opponents following a home loss.
- The Cardinals have led after 3 innings in six of their last seven games against American League opponents.
- The Yankees have trailed after 5 innings in seven of their last eight Saturday games as favorites.
Why the New York Yankees will win
- The Cardinals have lost each of their last six night games against AL East opponents that held a winning record.
- The Yankees have won each of their last six Saturday night games against National League opponents that held a losing record.
- The Cardinals have failed to cover the run line in seven of their last eight home games against American League opponents.
- The Yankees have covered the run line each of their last six Saturday night games against National League opponents that held a losing record.
- The Cardinals have trailed after 5 innings in each of their last nine home games against American League opponents that held a winning record.
- The Yankees have led after 3 innings in seven of their last eight night games against the Cardinals.
- The Cardinals have lost the first inning in seven of their last eight night games against American League opponents.
St. Louis Cardinals Player Prop Facts
- Sonny Gray has recorded seven or more strikeouts in each of his last four appearances against AL opponents that held a winning record.
- Sonny Gray has recorded a win in each of his last four appearances against AL opponents.
- Nolan Arenado has hit a home run in each of his last two appearances with the Cardinals as home underdogs against AL opponents.
- Nolan Arenado has recorded at least one hit in each of his last 15 appearances against the Yankees.
- Masyn Winn has recorded a Double in each of the Cardinals’ last three games as home underdogs against AL East opponents.
- Victor Scott II ranks T5th in the league in Steals (31) this season.
New York Yankees Player Prop Facts
- Giancarlo Stanton has hit a home run in three of the Yankees’ last four night games against opponents that held a losing record.
- Max Fried has recorded six or more strikeouts in each of his last nine appearances in night games against teams that held a losing record.
- Giancarlo Stanton has recorded at least one hit in each of the Yankees’ last 10 games against opponents that held a losing record.
- Giancarlo Stanton has recorded a Double in each of his last three appearances against the Cardinals.
- Max Fried has recorded a win in seven of his last eight appearances with his team as a road favorite against NL Central opponents .
- Aaron Judge ranks 1st amongst qualified players for Batting Average (.330) this season.
Cardinals vs Yankees Prediction
The Yankees have been riding the struggle bus for a while, but they’re still a talented team capable of turning things around, and Fried has been solid this year despite some recent hiccups. On the season, Fried has a 2.94 ERA and 1.10 WHIP. Gray had a horrible month of July, and he now has a 4.06 ERA on the season. With Fried on the mound, this feels like a spot where the Yankees can get a much-needed win.

