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Chicago Cubs vs Arizona Diamondbacks 5/22/22 MLB Picks, Predictions, Odds

Arizona Diamondbacks (21-21) vs. Chicago Cubs (15-24)
May 22, 2022 2:20 pm EDT
The Line: Chicago Cubs -135 / Arizona Diamondbacks +115; Over/Under: -7.5
(Get latest betting odds)

The Arizona Diamondbacks and the Chicago Cubs meet in MLB action from Wrigley Field on Sunday.

The Arizona Diamondbacks will look to complete the sweep after a 7-6 win in extra innings on Saturday over Chicago. Daulton Varsho’s got 37 hits, 7 home runs and 20 RBIs this season. Christian Walker has a team-high 10 home runs and 19 RBIs and Ketel Marte has a team-high 13 doubles while David Peralta has 6 doubles and Pavin Smith’s also got 27 hits and has a .225 batting average on the year. Merrill Kelly will start here and is 3-2 with a 3.27 ERA and 40 strikeouts this season.


The Chicago Cubs will look to salvage a win and bounce back from their loss to the Diamondbacks on Saturday. Willson Contreras has 31 hits and a .258 batting average while Patrick Wisdom has a team-high 8 home runs, 19 RBIs and 8 doubles on the year. Seiya Suzuki also has 19 RBIs and 11 doubles chipped in for the Cubbies up to this point in the year. Ian Happ leads the Cubs with 32 hits with a .269 batting average as well on the year. Wade Miley will start here and is 1-0 with a 2.70 ERA and 7 strikeouts this season.

Arizona is 21-63 in their last 84 road games and 57-118 in their last 175 games overall while the while the over is 8-1-1 in their last 10 games as a road underdog. Chicago is 9-19 in their last 28 games overall and 14-38 in their last 52 home games while the under is 6-1-1 in their last 8 games overall.

I get the case to be made for Chicago at home here, but the thing is that the Diamondbacks have been the better team in the series and keep finding ways to win while I’m still not sure what to make of the Cubs with Wade Miley on the mound. He’s a solid arm, but it’s a small sample size to suggest he’s full rocking and rolling in the Windy City. I like Merrill Kelly and how the D-Backs have played as a team in this series so give me the Diamondbacks here.

Chris Ruffolo's Free Pick: Arizona +115

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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