Chicago Cubs vs Detroit Tigers Prediction 7/22/26 MLB Picks Today

The Detroit Tigers and the Chicago Cubs meet Wednesday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Detroit Tigers vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Detroit Tigers will send out Keider Montero for the start here and Montero is 6-5 with a 3.22 ERA and 70 strikeouts this season. Colin Rea will start for the Cubs and is 7-6 with a 4.74 ERA and 76 strikeouts this season.

Detroit Tigers Recap

The Detroit Tigers will be out to bounce back from an 11-2 loss at the hands of the Cubs on Tuesday to sit at 47-54 this season. After this series, the Tigers will take on the Royals in a series at home.

Tigers Alternate Wins & Losses In 4 Straight

Riley Greene has 103 hits with 20 doubles, 15 home runs and 50 RBIs while Kevin McGonigle has 103 hits with 20 doubles, 3 triples, 9 home runs and 35 RBIs. Spencer Torkelson’s added 70 hits with 18 doubles, 18 home runs and 49 RBIs and Dillon Dingler has 91 hits with 20 doubles, 21 home runs and 63 RBIs this season. Colt Keith’s added 67 hits with 10 doubles and 24 RBIs and Matt Vierling has 51 hits with 12 doubles, 5 home runs and 30 RBIs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over Detroit on Tuesday to sit at 57-44 this season. After this series, the Cubs will head on the road for a series against the Pittsburgh Pirates.

Cubs Win 3 Of Last 4

Ian Happ has 77 hits with 17 doubles and 18 home runs and 44 RBIs while Alex Bregman has 93 hits with 15 doubles, a triple, 10 home runs and 43 RBIs. Nico Hoerner’s added 97 hits with 23 doubles, 4 home runs and 43 RBIs and Moises Ballesteros has 36 hits with 6 home runs and 23 RBIs. Pete Crow-Armstrong’s also added 105 hits with 16 doubles, 4 triples, 21 home runs and 53 RBIs as well on the year. Carson Kelly has also contributed 61 hits with 10 doubles, 6 home runs and 33 RBIs. Michael Busch has 89 hits wtih 17 doubles, 13 home runs and 53 RBIs. Dansby Swanson also has 69 hits with 16 home runs and 58 RBIs.

Detroit Tigers @ the Chicago Cubs Betting Trends: July 22, 2026

• Probable Starting Pitcher: Colin Rea      Record this season: 7-6      ERA: 4.74
• Home Record: 3-2
• Last 5 against Tigers: 0-1

Why the Chicago Cubs will win

• The Cubs have won five of their last six games after playing the previous day.
• The Tigers have lost 12 of their last 15 road games against National League opponents.
• The favorites have covered the run line in five of the last six games between the Tigers and Cubs.
• The Tigers have failed to cover the run line in eight of their last 10 games as underdogs against NL Central opponents.
• The Tigers have trailed after 5 innings in nine of their last 11 games as underdogs against National League opponents.
• The Cubs have won the first inning in six of their last seven games as favorites against AL Central opponents.
• The Tigers have trailed after 3 innings in eight of their last 10 games as underdogs against NL Central opponents.

• Probable Starting Pitcher: Keider Montero      Record this season: 6-5      ERA: 3.22
• Road Record: 2-2
• Last 5 against Cubs: 0-0

Why the Detroit Tigers will win

• The Tigers have won each of their last six games as underdogs against the Cubs following a loss.
• The Cubs have lost five of their last six games as favorites against the Tigers following a win.
• The Cubs have failed to cover the run line in each of their last nine night games against AL Central opponents following a home win.
• The Tigers have covered the run line in each of their last eight games against the Cubs following a loss.
• The Tigers have won the first inning in three of their last four games.
• The Tigers have led after 3 innings in five of their last six night games against the Cubs at Wrigley Field.
• The Tigers have led after 5 innings in each of their last six Wednesday games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Tigers’ last six games against NL Central opponents have gone OVER the total runs line.
• Each of the last four games between the Tigers and Cubs at Wrigley Field have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Cubs’ last eight games against AL Central opponents.
• There has been at least one run scored in the first inning in each of the Tigers’ last five games.

Chicago Cubs Player Prop Facts

• Pete Crow-Armstrong has hit a home run in four of the Cubs’ last five Wednesday games at Wrigley Field.
• Michael Busch has recorded at least one hit in each of the Cubs’ last 11 home games against AL opponents.
• Pete Crow-Armstrong ranks T4th in the league in Steals (25) this season.

Detroit Tigers Player Prop Facts

• Dillon Dingler has hit at least one home run in four of the Tigers’ last five road games against NL opponents.
• Keider Montero has recorded four or more strikeouts in five of his last six appearances against NL opponents that held a winning record.
• Hao-Yu Lee has recorded at least one hit in each of his last 11 appearances in night games against teams that held a winning record.
• Kevin McGonigle ranks 7th amongst qualified players for On Base Percentage (.391) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks this season (447).
• The Cubs rank 1st in the league for walks this season (447).
• The Tigers rank 30th in the league for steals this season (33).
• The Tigers rank 30th in the league for steals this season (33).

Detroit Tigers vs. Chicago Cubs Prediction

I’m on the Tigers in this one. I just think that Montero’s the better starting option in this game and I think that the Cubs start to falter here. The Tigers offense has ticked up recently and I think they get the job done in this one. Give me Detroit here.