Cubs vs Padres Prediction 10/1/25 MLB Picks Today

The San Diego Padres and the Chicago Cubs meet Wednesday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will start Dylan Cease here and Cease was 8-12 with a 4.55 ERA and 215 strikeouts this season. The Chicago Cubs will start Andrew Kittredge here and Kittredge was 4-3 with a 3.40 ERA and 64 strikeouts in the regular season.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound after a 3-1 loss to the Cubs in game one on Tuesday in the series opener.

Padres Trying To Force Game Three

Manny Machado has 169 hits including a team-high 33 doubles, 27 home runs, 95 RBIs and 14 stolen bases while Fernando Tatis Jr. has 159 hits with 25 home runs and 71 RBIs along with 32 stolen bases of his own this season. Luis Arraez has added 181 hits with 30 doubles, 4 triples, 8 home runs and 61 RBIs while Jackson Merrill’s added 116 hits with 16 home runs and 67 RBIs as well. Xander Bogaerts also has 30 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 71 RBIs as well this season.

Why the San Diego Padres will win

• The Padres have won each of their last six day games against NL Central opponents following a loss.
• The Cubs have lost four of their last five playoff games as favorites.
• The Padres have covered the run line in 13 of their last 14 day games against National League opponents following a loss.
• The Cubs have failed to cover the run line in each of their last eight Wednesday games as favorites against NL West opponents.

San Diego Padres Player Prop Facts

• Jackson Merrill has recorded a Double in three of the Padres’ last four road games.
• Dylan Cease has recorded a win in three of his last four appearances against NL opponents.
• Dylan Cease has recorded seven or more strikeouts in each of his last four appearances in day games against NL Central teams that held a winning record.
• Jose Iglesias has recorded at least one hit in each of his last 15 appearances in day games against NL Central teams that held a winning record.
• Jose Iglesias has hit a home run in each of his last two appearances with the Padres as underdogs.
• Luis Arraez ranks T2nd in the league in Hits (181) this season.

Chicago Cubs Recap

The Chicago Cubs come into this one looking to make their first NLDS appearance since 2017 after their opening win on Tuesday.

Cubs Looking For Sweep

Ian Happ has 138 hits with 32 doubles, 23 home runs and 79 RBIs. Kyle Tucker has 133 hits including 25 doubles, 4 triples, 22 home runs and 73 RBIs while Seiya Suzuki also has 140 hits with 31 doubles and 32 home runs and 103 RBIs of his own. Pete Crow-Armstrong also has contributed 146 hits, 37 doubles, 4 triples, 31 home runs and 95 RBIs as well this season. Dansby Swanson has added 24 home runs and 77 RBIs, while also having 168 strikeouts and Suzuki has 164 strikeouts so far this season. Crow-Armstrong also has a team-high 35 stolen bases while Nico Hoerner has 29 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 25 doubles, 5 triples, 34 home runs and 90 RBIs this season.

Why the Chicago Cubs will win

• The Padres have lost each of their last six day games against teams that held a winning record.
• The Cubs have won each of their last four games.
• The favorites have covered the run line in each of the Cubs’ last six games.
• The Padres have failed to cover the run line in each of their last four playoff games.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit at least one home run in each of the Cubs’ last five games.
• Ian Happ has recorded a Double in three of the Cubs’ last four games against opponents that held a winning record.
• Seiya Suzuki has recorded at least one hit in each of his last 10 home appearances.
• Nico Hoerner ranks 6th in the league in Hits (178) this season.

Total Runs Facts

• Each of the Cubs’ last six playoff games as home favorites have gone UNDER the total runs line.
• Six of the Padres’ last seven games against NL Central opponents have gone UNDER the total runs line.

Cubs vs Padres Prediction

I’m on the Cubs here. I just can’t get there with the Padres, as Dylan Cease has been complete fade material on the road this season, with an ERA well over five. It’ll be interesting to see how the Cubs handle the pitching duties in Wednesday’s matchup, but I still think that San Diego’s best chance in the series was in game one. I just don’t like the matchup for Cease here. Give me the Cubs.