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Chicago White Sox vs Cleveland Guardians Prediction 7-11-25 Picks

Cleveland Guardians (43-48) vs. Chicago White Sox (31-62)
July 11, 2025 7:10 pm EDT
The Line: Chicago White Sox -102 / Cleveland Guardians -119; Over/Under: 9
(Get latest betting odds)

The Cleveland Guardians and the Chicago White Sox meet Friday in MLB doubleheader action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Chicago White Sox prediction.

Starting Pitching Matchup

Logan Allen is slated to start game one for Cleveland and is 5-7 with a 4.07 ERA and 65 strikeouts while Gavin Williams will get the nod in game two and is 5-4 with a 3.61 ERA and 90 strikeouts this season. Shane Smith will get the start for the White Sox in game one and is 3-7 with a 4.20 ERA and 76 strikeouts this season while Jonathan Cannon will start game two and is 3-7 with a 4.50 ERA and 56 strikeouts this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 4-2 win over the Houston Astros from Wednesday’s matchup, sitting at 40-48 on the year. After this series, the Guardians will head home to take on the Athletics.

Guardians Win Three In A Row

Steven Kwan has 101 hits as part of a .292 batting average and 6 home runs, 20 doubles and 29 RBIs. Kyle Manzardo has 55 hits with 11 doubles, 2 triples, 13 home runs and 33 RBIs as well this year. Gabriel Arias has 17 doubles but also 88 strikeouts and Manzardo has 73 strikeouts so far this season. Arias has also added 6 home runs and 31 RBIs and Jose Ramirez has chipped in 17 home runs and 45 RBIs. Carlos Santana has also added 69 hits with 10 home runs and 38 RBIs as well this season.

Why the Cleveland Guardians will win

  • The White Sox have lost each of their last 11 Friday day games against AL Central opponents.
  • The Guardians have won each of their last seven games against the White Sox.
  • The White Sox have failed to cover the run line in 15 of their last 16 day games against the Guardians at Rate Field following a win.
  • The Guardians have covered the run line each of their last six road games against AL Central opponents that held a losing record.

Cleveland Guardians Player Prop Facts

  • Jose Ramirez has hit a home run in each of the Guardians’ last three games against AL opponents.
  • Carlos Santana has recorded at least one hit in each of his last 12 road appearances after not playing the previous day.
  • Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
  • Jose Ramirez is one of only three players to hit over .300 and have 45+ RBIs this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to build on their 2-1 win over the Blue Jays from Wednesday’s matchup to sit at 30-60 on the year. After this series, the White Sox will take on the Pittsburgh Pirates on the road following the all-star break.

White Sox Snap Three-Game Losing Streak

Lenyn Sosa has 74 hits including 14 doubles and 29 RBIs. Andrew Benintendi has 51 hits including 10 doubles, 10 home runs, 34 RBIs and a .223 batting average while Miguel Vargas has 72 hits, 21 doubles, 10 home runs and 34 RBIs. Brooks Baldwin has also added 20 RBIs while Luis Robert Jr. has a team-high 22 stolen bases along with 32 RBIs so far this season. Chase Meidroth has added 61 hits with 11 stolen bases as well as 6 doubles this season.

Why the Chicago White Sox will win

    • The Guardians have lost each of their last four games as favorites on the first leg of a doubleheader.
    • The underdogs have won each of the Guardians’ last three games.
    • The White Sox have covered the run line in eight of their last nine day games against American League opponents that held a losing record.
    • The Guardians have failed to cover the run line each of their last seven Friday games against American League opponents that held a losing record.

Chicago White Sox Player Prop Facts

  • Michael A. Taylor has recorded a Double in each of his last three appearances with the White Sox as underdogs.
  • Andrew Benintendi has recorded at least one hit in each of his last 10 appearances against AL Central opponents that held a losing record.
  • Andrew Benintendi has hit a home run in three of his last eight home appearances.
  • Luis Robert ranks T10th in the league in Steals (22) this season.

Total Runs Facts

  • Each of the Guardians’ last five games as road favorites have gone UNDER the total runs line.
  • Each of the White Sox’s last four day games against American League opponents have gone UNDER the total runs line.

Cleveland Guardians vs. Chicago White Sox Prediction

I’m on the under in both games here. I just think this is going to be a low-scoring double-header with two teams that I don’t trust worth a lick to be able to provide offensively in this series. I think this could be a series where we see a pair of first to three wins in both matchups, so give me the under in game one and game two here.

Chris Ruffolo's Free Pick: UNDER

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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