White Sox vs Guardians Prediction 7-13-25 MLB Picks

The Cleveland Guardians and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a White Sox vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Joey Cantillo for the start here, and Cantillo is 1-0 with a 3.79 ERA and 48 strikeouts this season. This will be Cantillo’s second career start against the White Sox. The Chicago White Sox will trot out Aaron Civale here, and Civale is 1-6 with a 5.17 ERA and 33 strikeouts this season. In his career, Civale is 1-0 with a 1.64 ERA and 6 strikeouts against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 6-2 win over the White Sox from Saturday’s matchup to sit at 45-49 on the year. After the All-Star break, the Guardians will head home for a series against the Athletics.

Guardians Win 5 Of Their Last 6

Steven Kwan has 101 hits as part of a .292 batting average and 6 home runs, 20 doubles, and 29 RBIs. Kyle Manzardo has 55 hits with 11 doubles, 2 triples, 13 home runs, and 33 RBIs as well this year. Gabriel Arias has 17 doubles but also 88 strikeouts, and Manzardo has 73 strikeouts so far this season. Arias has also added 6 home runs and 31 RBIs, and Jose Ramirez has chipped in 17 home runs and 45 RBIs. Carlos Santana has also added 69 hits with 10 home runs and 38 RBIs this season.

Why the Cleveland Guardians will win

• The White Sox have lost each of their last nine day games against teams that held a losing record.
• The Guardians have won each of their last seven day games against American League opponents that held a losing record.
• The Guardians have covered the run line in each of their last eight road games after playing the previous day.
• The White Sox have failed to cover the run line in 10 of their last 12 home games against AL Central opponents that held a losing record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in four of the Guardians’ last six games against AL opponents.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Lane Thomas has recorded at least one hit in each of his 12 previous road appearances against AL Central opponents that held a losing record.
• Jose Ramirez ranks T2nd in the league in Steals (29) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their loss at the hands of the Guardians to sit at 32-64 this year. After the all-star break, the White Sox will have a road interleague series against the Pittsburgh Pirates.

White Sox Drop 5 Of Their Last 7

Lenyn Sosa has 74 hits, including 14 doubles and 29 RBIs. Andrew Benintendi has 51 hits, including 10 doubles, 10 home runs, 34 RBIs, and a .223 batting average, while Miguel Vargas has 72 hits, 21 doubles, 10 home runs, and 34 RBIs. Brooks Baldwin has also added 20 RBIs, while Luis Robert Jr. has a team-high 22 stolen bases along with 32 RBIs so far this season. Chase Meidroth has added 61 hits with 11 stolen bases as well as 6 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won nine of their last 10 games as underdogs against American League opponents following a home loss.
• The Guardians have lost four of their last five day games after playing the previous day.
• The White Sox have covered the run line in each of their last six day games against American League opponents following a loss.
• The Guardians have failed to cover the run line in three of their last four games as favorites after playing the previous day.

Chicago White Sox Player Prop Facts

• Aaron Civale has recorded four or more strikeouts in each of his six previous appearances in day games against AL Central teams that held a losing record.
• Luis Robert has recorded at least one hit in eight of his last nine home appearances against the Guardians.
• Andrew Benintendi has hit a home run in three of his last nine appearances in day games.
• Luis Robert ranks T10th in the league in Steals (22) this season.

Total Runs Facts

• Each of the White Sox’s last six day games against American League opponents have gone UNDER the total runs line.
• Seven of the Guardians’ last eight games as road favorites have gone UNDER the total runs line.

White Sox vs Guardians Prediction

I’m on the under here. I know the pitching matchup of Cantillo vs. Civale isn’t the most attractive, but I think this is actually a decent matchup here, as Cantillo’s been solid. However, I still worry about the Guardians’ offense, and Civale just hasn’t gotten much run support in his starts in a White Sox uniform. I think we have another low-scoring AL Central game, so I’ll side with the under in this one.