Chicago White Sox vs Minnesota Twins Prediction 5/27/26 MLB Picks Today

The Minnesota Twins and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Connor Prielipp here and Prielipp is 1-2 with a 4.03 ERA and 30 strikeouts this season. This will be Prielipp’s first career start against the White Sox. The Chicago White Sox will start David Sandlin here and this will be Sandlin’s major league debut.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their 5-3 win over the White Sox last time out to sit at 27-28 this season. After this series, the Twins will head on the road for a series against the Pittsburgh Pirates.

Twins Win 7 Of Last 9

Entering Tuesday, Byron Buxton has 50 hits with 10 doubles, a triple, 16 home runs and 26 RBIs while Josh Bell’s added 42 hits with 8 doubles, 5 home runs and 30 RBIs. Luke Keaschall has 42 hits with 8 doubles, a homer and 18 RBIs and Matt Wallner has 20 hits with 3 doubles, 4 home runs and 10 RBIs. Brooks Lee has 6 home runs with 27 RBIs and Victor Caratini has 17 RBIs while Ryan Jeffers has 36 hits with 6 doubles, a triple, 7 home runs and 26 RBIs this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their loss at the hands of the Twins on Tuesday to fall to 27-27 this season. After this series, the White Sox will take on the Detroit Tigers in a series at home.

White Sox Lose 3 Of Last 4

Going into Tuesday, Munetaka Murakami has 44 hits with 18 home runs and 37 RBIs while Miguel Vargas has 44 hits with 8 doubles, a triple, 12 home runs and 31 RBIs and Colson Montgomery has 41 hits with 8 doubles, 13 home runs and 32 RBIs. Luisangel Acuna has 16 hits and Tristan Peters has 32 hits with 6 doubles so far this season. Chase Meidroth also has 50 hits with 9 doubles, 4 home runs and 13 RBIs this year.

Minnesota Twins @ the Chicago White Sox Betting Trends: May 27, 2026

• Probable Starting Pitcher: Davis Martin      Record this season: 7-1      ERA: 2.04
• Home Record: 3-0
• Last 5 against Twins: 2-3

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight games against the Twins.
• The Twins have lost each of their last four games against the White Sox following a win.
• The White Sox have covered the run line in seven of their last eight games against the Twins.
• The Twins have failed to cover the run line in each of their last four games against the White Sox following a win.
• The White Sox have led after 5 innings in six of their last seven home games against AL Central opponents that held a losing record.
• The Twins have trailed after 3 innings in four of their last five games at Rate Field.

• Probable Starting Pitcher: Connor Prielipp      Record this season: 1-2      ERA: 4.03
• Road Record: 0-1
• Last 5 against White Sox: –

Why the Minnesota Twins will win

• The Twins have won five of their last six games as road underdogs.
• The White Sox have lost six of their last seven games as home favorites following an extra innings loss.
• The White Sox have failed to cover the run line in each of their last eight games as favorites following an extra innings loss.
• The Twins have covered the run line in seven of their last eight games as underdogs.
• The White Sox have trailed after 5 innings in four of their last five games as favorites against American League opponents.

Total Runs Facts

• Seven of the White Sox’s last eight home games have gone OVER the total runs line.
• Five of the Twins’ last six games after going to extra innings have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Twins’ last nine games as underdogs against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last seven Wednesday games against American League opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in two of the White Sox’s last three games as home favorites.
• Andrew Benintendi has recorded at least one hit in 12 of his last 13 appearances against the Twins after playing the previous day.
• Munetaka Murakami ranks 2nd in the league in Home Runs (19) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in nine of his last 13 appearances in night games.
• Ryan Jeffers has recorded at least one hit in each of his last nine appearances with the Twins as road underdogs against AL Central opponents.
• Byron Buxton ranks T5th in the league in Home Runs (16) this season.

Matchup/League Facts

• The White Sox rank 30th in the league for doubles this season (64).
• The White Sox rank 29th in the league for hits this season (411).
• The Twins rank 25th in the league for strikeouts this season (426).
• The Twins rank T6th in the league for home runs allowed this season (49).

Minnesota Twins vs. Chicago White Sox Prediction

I’m on the White Sox here. I’ve been impressed with Sandlin’s stuff at the minor league level, and I think he can have a solid major league debut here. I haven’t been impressed with Prielipp’s game to this point and I think the White Sox back up Sandlin here for the win.