Chicago White Sox vs San Diego Padres Prediction 9/21/25 MLB Picks Today

The San Diego Padres and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Chicago White Sox prediction.

Starting Pitching Matchup

The San Diego Padres will send out Michael King for the start here and King is 4-3 with a 3.84 ERA and 69 strikeouts this season. This will be King’s first career start against the White Sox. Sean Burke will get the nod for the White Sox and is 4-10 with a 4.29 ERA and 119 strikeouts this season. This will be Burke’s first career start against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their 7-3 win over the White Sox from Saturday’s matchup to sit at 84-71 this season. After this series, the Padres will go back to Petco Park for a series against the Milwaukee Brewers.

Padres Snap Two-Game Slide

Manny Machado has 164 hits including a team-high 33 doubles, 26 home runs, 92 RBIs and 14 stolen bases while Fernando Tatis Jr. has 153 hits with 22 home runs and 65 RBIs along with 30 stolen bases of his own this season. Luis Arraez has added 170 hits with 29 doubles, 4 triples, 7 home runs and 57 RBIs while Jackson Merrill’s added 107 hits with 14 home runs and 61 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 68 RBIs as well this season.

Why the San Diego Padres will win

• The White Sox have lost each of their last seven games after playing the previous day.
• The Padres have won seven of their last eight games against the White Sox.
• The White Sox have failed to cover the run line in each of their last four games after playing the previous day.
• The Padres have covered the run line in each of their last six Sunday games as favorites.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four games as favorites.
• Jackson Merrill has recorded a Double in each of the Padres’ last three games as road favorites.
• Jose Iglesias has recorded at least one hit in each of his last 10 appearances with his team as a favorite against the White Sox.
• Luis Arraez ranks T5th in the league in Hits (171) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their loss to San Diego on Saturday to fall to 58-97 on the year. After this set, the White Sox will take to the road for a series against the New York Yankees.

White Sox Drop 7 Of Last 8

Lenyn Sosa has 128 hits including 18 doubles, 20 home runs and 70 RBIs. Andrew Benintendi has 101 hits including 16 doubles, 20 home runs, 62 RBIs and a .240 batting average while Miguel Vargas has 108 hits, 31 doubles, 15 home runs and 55 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 111 hits with 13 stolen bases as well as 15 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won six of their last seven games as underdogs against National League opponents following a home loss.
• The Padres have lost four of their last five games as favorites against American League opponents.
• The White Sox have covered the run line in each of their last seven games against National League opponents following a loss.
• The Padres have failed to cover the run line each of their last six day games against American League opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit at least one home run in four of the White Sox’s last six day games against NL opponents that held a winning record.
• Korey Lee has recorded at least one hit in each of his last six appearances against NL opponents.

Total Runs Facts

• Seven of the White Sox’s last eight games as underdogs have gone UNDER the total runs line.
• Six of the Padres’ last seven day games against AL Central opponents have gone UNDER the total runs line.

San Diego Padres vs. Chicago White Sox Prediction

I’m on the Padres here. Michael King for me is still a solid option even though he hasn’t had the best two starts since returning from injury as he’s still one of the more consistent options the Padres have when he’s on point. The White Sox got the better of the Padres on Friday but we saw San Diego come through with a sense of urgency on Saturday and I think they come back with that same fire on Sunday. Give me the Padres here.