Reds vs Pirates Prediction 9/23/25 MLB Picks Today

The Pittsburgh Pirates and the Cincinnati Reds meet Tuesday in MLB action from Sutter Health Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Reds vs Pirates Prediction.

Starting Pitching Matchup

The Pittsburgh Pirates will start Johan Oviedo here and Oviedo is 2-0 with a 3.52 ERA and 32 strikeouts this season. In his last five starts against the Reds, Oviedo is 1-1 with a 5.48 ERA and 23 strikeouts. The Cincinnati Reds will trot out Brady Singer for the start here and Singer is 14-10 with a 3.86 ERA and 155 strikeouts this season. In his last five starts against the Pirates, Singer is 2-3 with a 6.29 ERA and 20 strikeouts.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to add on to their 11-0 win over the Athletics from Sunday’s series finale to sit at 67-89 this season. After this series, the Pirates will head on the road for their final series against the Atlanta Braves.

Pirates Win Back-To-Back Games

Bryan Reynolds has 138 hits with 36 doubles, 16 home runs and 73 RBIs while also posting 170 strikeouts so far this season. Oneil Cruz has posted a team-high 19 home runs and 59 RBIs with 38 stolen bases. Cruz also has 169 strikeouts as well this season. Tommy Pham has 17 doubles and Andrew McCutchen has 111 hits with 22 doubles as well this season.

Why the Pittsburgh Pirates will win

• The Pirates have won three of their last four games as underdogs against the Reds.
• The Reds have lost eight of their last nine night games against teams that held a losing record.
• The Pirates have covered the run line in each of their last nine Tuesday games against the Reds.
• The Reds have failed to cover the run line in seven of their last eight games as home favorites following a win.

Pittsburgh Pirates Player Prop Facts

• Johan Oviedo has recorded five or more strikeouts in each of his last five road appearances.
• Andrew McCutchen has recorded at least one hit in each of his last eight road appearances after not playing the previous day.
• Johan Oviedo has recorded a win in three of his last four road appearances against NL Central opponents that held a winning record.
• Joey Bart has hit a home run in each of his last two appearances.
• Oneil Cruz ranks 4th in the league in Steals (38) this season.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to add on to their 1-0 win over the Chicago Cubs last time out to improve to 80-76 this season. After this series, the Reds’ final series will be on the road against the division rival Milwaukee Brewers.

Reds Win 5 In A Row

Elly De La Cruz has 159 hits with 20 home runs, 83 RBIs, 31 doubles and 36 stolen bases while TJ Friedl has 143 hits with 20 doubles, 13 home runs and 50 RBIs with 12 stolen bases. Gavin Lux has added 115 hits with 26 doubles and 51 RBIs while Spencer Steer has 21 home runs and 74 RBIs and Matt McLain has added 15 homers, 49 RBIs and 18 stolen bases as well on the year. Jose Trevino’s also chipped in 20 doubles as well this season.

Why the Cincinnati Reds will win

• The Pirates have lost each of their last eight games against NL Central opponents that held a winning record.
• The Reds have won each of their last six home games.
• The Pirates have failed to cover the run line in each of their last seven games against NL Central opponents.
• The Reds have covered the run line in five of their last six home games against the Pirates.

Cincinnati Reds Player Prop Facts

• Spencer Steer has hit at least one home run in each of the Reds’ last two night games.
• Brady Singer has recorded eight or more strikeouts in each of his last four appearances with the Reds as home favorites.
• Miguel Andujar has recorded at least one hit in each of his last seven appearances against NL opponents.
• Brady Singer has recorded a win in each of his last five home appearances.
• Elly De La Cruz ranks T6th in the league in Steals (36) this season.

Total Runs Facts

• Each of the Pirates’ last seven games as underdogs against the Reds have gone UNDER the total runs line.
• Nine of the Reds’ last 10 games as favorites against the Pirates have gone UNDER the total runs line.

Reds vs Pirates Prediction

I’m on the Reds here. I get the case to be made for an underdog in some spots, but the thing is that these are two teams with different motivation levels in the last week of the season, and it’s not even close. The Reds have picked up their play at the right time of the year and now have one of their better starters going in this game. I think that’s enough to best a Pirates’ lineup that has no punch offensively right now. Give me Cincinnati here.