Cincinnati Reds vs San Francisco Giants Prediction 4/16/26 MLB Picks Today

The San Francisco Giants and the Cincinnati Reds meet Thursday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Cincinnati Reds prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Landen Roupp for the start here and Roupp is 2-1 with a 3.24 ERA and 18 strikeouts this season. This will be Roupp’s second career start against the Reds. Chase Burns will start the start for the Reds and is 1-1 with a 3.31 ERA and 18 strikeouts this season. This will be Burns’ first career start against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their 8-3 loss at the hands of the Reds on Wednesday to sit at 6-12 this season. After this set, the Giants will head on the road for a series against the Washington Nationals.

Giants Lose 4 In A Row

Luis Arraez has 21 hits with a double, 2 triples and 6 RBIs while Willy Adames has 18 hits with 9 doubles, 3 home runs and 6 RBIs. Matt Chapman has 3 doubles, a triple, a home run and 7 RBIs and Harrison Bader has a home run and 3 RBIs while Jung Hoo Lee has 13 hits with 6 doubles and a team-high 7 RBIs. Heliot Ramos has 15 hits with 2 doubles and 7 RBIs but also has a team-high 24 strikeouts this season. Rafael Devers also has 16 hits with a double, 2 home runs and 6 RBIs.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to add on to their win over San Francisco on Wednesday to sit at 11-7 on the year. After this series, the Reds will head on the road for a set against the Minnesota Twins.

Reds Win Back-To-Back Games

Sal Stewart has 20 hits with 4 doubles, 7 home runs, 17 RBIs and a .323 batting average while Elly De La Cruz has 20 hits with 3 doubles, 6 home runs and 11 RBIs. Matt McLain’s added 13 hits with 3 doubles and 3 RBIs and Eugenio Suarez has 16 hits with a double, 3 homers and 9 RBIs as well on the year. Spencer Steer also has 12 hits with 3 doubles, 3 home runs and 5 RBIs.

San Francisco Giants @ Cincinnati Reds Betting Trends: April 16, 2026

• Probable Starting Pitcher: Chase Burns      Record this season: 1-1      ERA: 3.31
• Home Record: 1-1
• Last 5 against Giants: –

Why the Cincinnati Reds will win

• The Reds have won each of their last seven day games against NL West opponents that held a losing record.
• The Giants have lost each of their last four games.
• The Giants have failed to cover the run line each of their last nine Thursday day games against teams that held a winning record.
• The Reds have covered the run line in six of their last seven day games against NL West opponents that held a losing record.
• The Giants have trailed after 3 innings in seven of their last eight games at Great American Ball Park against opponents that held a winning record.
• The Reds have won the first inning in three of their last four home games against NL West opponents that held a losing record.
• The Giants have trailed after 5 innings in seven of their last eight games at Great American Ball Park against opponents that held a winning record.

• Probable Starting Pitcher: Landen Roupp      Record this season: 2-1      ERA: 3.24
• Road Record: 2-0
• Last 5 against Reds: 0-1

Why the San Francisco Giants will win

• The Reds have lost four of their last five games as home favorites against NL West opponents following a win.
• The Giants have won seven of their last eight day games against the Reds following a loss.
• The Giants have covered the run line in each of their last 11 games as underdogs against NL Central opponents.
• The Reds have failed to cover the run line in seven of their last eight games as home favorites against NL West opponents.
• The Reds have trailed after 3 innings in three of their last four day games against opponents that held a losing record.
• The Reds have lost the first inning in four of their last five day games against National League opponents that held a losing record.
• The Reds have trailed after 5 innings in each of their last three day games against National League opponents.

Total Runs Facts

• Each of the Reds’ last seven games after playing the previous day have gone OVER the total runs line.
• Each of the Giants’ last six day games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last nine games as home favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Giants’ last six day games at Great American Ball Park.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has hit a home run in three of the Reds’ last four games against opponents that held a losing record.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last nine home games against NL West opponents.

San Francisco Giants Player Prop Facts

• Willy Adames has hit a home run in four of his last six road appearances against the Reds after playing the previous day.
• Rafael Devers has recorded at least one hit in each of his 10 previous appearances against the Reds after playing the previous day.
• Luis Arraez ranks T7th amongst qualified players for Batting Average (.333) this season.

Matchup/League Facts

• The Reds rank T29th in the league for doubles this season (17).
• The Reds rank 29th in the league for batting average this season (.207).
• The Giants rank 30th in the league for runs scored this season (55).
• The Giants rank 30th in the league for home runs this season (9).

San Francisco Giants vs. Cincinnati Reds Prediction

I’m on the Giants in this one. I just think that Roupp is the more trustworthy starting pitching option here as Chase Burns has a tendency to be erratic, which is a flaw that sometimes comes with the velocity that Burns tosses with. The Giants still have a decent lineup and I think this is a spot for them to break through on Thursday. Give me the Giants.