Cleveland Guardians vs Chicago White Sox Prediction 9/14/26 MLB Picks Today

The Chicago White Sox and the Cleveland Guardians meet Monday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Newcomb for the start here and Newcomb is 2-4 with a 2.77 ERA and 78 strikeouts this season. Gavin Williams will start for the Guardians and is 13-7 with a 3.78 ERA and 228 strikeouts this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from a 3-1 loss at the hands of the St. Louis Cardinals last time out to sit at 76-73 this season. After this series, Chicago will head home for a game against the Detroit Tigers.

White Sox Lose 5 Of Last 6

Munetaka Murakami has 84 hits with 31 home runs and 65 RBIs while Miguel Vargas has 135 hits with 30 doubles, a triple, 30 home runs and 79 RBIs and Colson Montgomery has 109 hits with 23 doubles, 31 home runs and 84 RBIs. Luisangel Acuna has 46 hits and Tristan Peters has 114 hits with 31 doubles, 12 home runs and 54 RBIs so far this season. Chase Meidroth also has 140 hits with 27 doubles, 14 home runs and 54 RBIs this year.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 9-2 win over Minnesota last time out to sit at 76-74 this season. After this series, the Guardians will take on the Athletics at home.

Guardians Alternate Wins & Losses In 9 Straight

Chase DeLauter has 134 hits with 28 doubles, 14 home runs and 62 RBIs while Steven Kwan has 139 hits with 21 doubles, 3 home runs and 30 RBIs and Jose Ramirez has 98 hits with 24 doubles, 11 home runs and 48 RBIs this season. Brayan Rocchio has also added 123 hits with 21 doubles, 13 home runs and 65 RBIs this season while Angel Martinez has 89 hits with 21 doubles, 15 homers and 53 RBIs and Rhys Hoskins has added 47 hits with 13 doubles, 13 home runs and 38 RBIs. Daniel Schneemann has 53 hits with 11 doubles, 6 home runs and 29 RBIs this season.

The Chicago White Sox @ Cleveland Guardians Betting Trends: September 14, 2026

• Probable Starting Pitcher: Gavin Williams      Record this season: 13-7      ERA: 3.78
• Home Record: 7-3
• Last 5 against White Sox: 1-0

Why the Cleveland Guardians will win

• The White Sox have lost seven of their last eight night games against teams that held a winning record.
• The Guardians have won seven of their last eight home games against the White Sox following a win.
• The White Sox have failed to cover the run line in each of their last six games.
• The Guardians have covered the run line in four of their last five games.
• The Guardians have won the first inning in three of their last four games against the White Sox.
• The Guardians have led after 3 innings in each of their last six Monday night games against the White Sox at Progressive Field.
• The Guardians have led after 5 innings in each of their last six Monday night games against the White Sox at Progressive Field.

• Probable Starting Pitcher: Sean Newcomb      Record this season: 2-4      ERA: 2.77
• Road Record: 0-3
• Last 5 against Guardians: 0-1

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight games as underdogs against AL Central opponents.
• The Guardians have lost each of their last five games as home favorites following a road win.
• The White Sox have covered the run line each of their last eight games against AL Central opponents that held a winning record.
• The Guardians have failed to cover the run line in 12 of their last 13 games as favorites against AL Central opponents following a win.
• The White Sox have won the first inning in four of their last five night games against AL Central opponents.
• The Guardians have trailed after 3 innings in each of their last six games as favorites.
• The Guardians have trailed after 5 innings in each of their last four night games against AL Central opponents.

Total Runs Facts

• Each of the Guardians’ last four games as favorites against AL Central opponents have gone UNDER the total runs line.
• Six of the White Sox’s last seven night games against AL Central opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in seven of the White Sox’s last eight road games against AL Central opponents.
• There has been at least one run scored in the first inning in four of the last five games between the White Sox and Guardians.

Cleveland Guardians Player Prop Facts

• Gavin Williams has recorded 10+ strikeouts in six of his last seven home appearances.
• Steven Kwan has recorded at least one hit in each of his last 13 appearances in night games against teams that held a winning record.
• Angel Martinez has hit a home run in two of his last three home appearances against AL opponents that held a winning record.
• Gavin Williams ranks T3rd in the league for total Strikeouts (228) this season.

Chicago White Sox Player Prop Facts

• Colson Montgomery has hit a home run in each of the White Sox’s last two road games against the Guardians.
• Miguel Vargas has recorded at least one hit in each of his last 10 Monday appearances against teams that held a winning record.

Matchup/League Facts

• The Guardians rank 30th in the league for home runs this season (142).
• The Guardians rank 29th in the league for slugging percentage this season (.374).
• The White Sox rank 26th in the league for hits this season (1171).
• The White Sox rank 26th in the league for batting average this season (.235).

Chicago White Sox vs. Cleveland Guardians Prediction

I’m on the under here. I just think this is your prototypical AL Central matchup with a hint of playoff preview mixed in. The White Sox are struggling right now and Gavin Williams has been lights out at home as of late. On the other side, Cleveland’s offense can be inconsistent as well and I think we get a low-scoring game here. Give me the under.