Cubs vs Cardinals Prediction 6/23/25 MLB Picks Today

The Chicago Cubs are visiting the St. Louis Cardinals on Monday, June 23^rd at the Busch Stadium in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Cardinals Prediction. We will examine:

The St. Louis Cardinals’ recent form and player performance

The Chicago Cubs’ recent form and player performance

Recent betting trends and streaks involving the St. Louis Cardinals

Recent betting trends and streaks involving the Chicago Cubs

Recent betting trends in games played between the Chicago Cubs vs St. Louis Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Chicago Cubs vs St. Louis Cardinals game

St. Louis Cardinals Preview

The St. Louis Cardinals have a 42-36 record this season and are sitting in third place in the NL Central. The Cardinals have a 24-15 home record and are 41-34 in over/under. They are coming off a 1-4 home defeat by the Reds, which snapped their previous five-game winning streak. They are playing the Guardians and the Pirates next.

The Cardinals have a .255 batting average this season, a .327 OBP, and a .391 Slugging percentage. St. Louis’ pitching staff has a 3.93 ERA and 1.26 WHIP. Brendan Donovan leads the Cardinals with 84 hits and a team-high .308 batting average, while Wilson Contreras leads the team in RBI, with 50, adding a team-high 10 home runs.

Matthew Liberatore (R) is the projected starting pitcher for the Cardinals, and he has a 4-6 record, 4.08 ERA, and 1.16 WHIP. He has been better at home, with a 3.95 ERA across seven home starts, but he has given up 4+ runs in three of his last four starts.

Chicago Cubs Preview

The Chicago Cubs have a 46-31 record this season and are sitting in first place in the NL Central. The Cubs have a 21-16 road record and are 38-31 in over/under. They are coming off a 6-14 home defeat by the Mariners, and are 1-3 in their last 4 games. Over is 4-0 in their last 4 games, and they are playing the Astros and the Guardians next.

The Cubs have a .254 batting average this season, a .325 OBP, and a .444 Slugging percentage. Chicago’s pitching staff has a 3.83 ERA and 1.26 WHIP. Kyle Tucker leads the Cubs with 81 hits, and he is the team’s best hitter with a .285 batting average. Seiya Suzuki leads the team in RBI, with 64.

Ben Brown (R) is the projected starting pitcher for the Cubs, and he has a 4-5 record, 5.57 ERA, and 1.48 WHIP. He has given up 6+ runs in three of his last five starts, and this will be his first career start against the Cardinals.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last nine games as home favorites against National League opponents.
• The Cubs have lost each of their last six night games at Busch Stadium following a loss.
• The Cardinals have covered the run line in 10 of their last 11 night games against National League opponents.
• The Cubs have failed to cover the run line in seven of their last eight games after playing the previous day.
• The Cubs have lost the first inning in each of their last three road games against NL Central opponents.
• The Cardinals have led after 3 innings in each of their last five games as favorites.
• The Cubs have trailed after 5 innings in each of their last six games as underdogs.

Why the Chicago Cubs will win

• The Cubs have won each of their last eight games against NL Central opponents following a loss.
• The Cardinals have lost each of their last four games as favorites following a home loss.
• The Cubs have covered the run line in each of their last eight games as road underdogs against NL Central opponents following a loss.
• The Cardinals have failed to cover the run line in nine of their last 10 games as favorites against NL Central opponents following a loss.
• The Cubs have won the first inning in three of their last four games against opponents that held a winning record.
• The Cubs have led after 5 innings in seven of their last eight night games against NL Central opponents.

Total Runs Facts

• Each of the Cardinals’ last five night games against National League opponents have gone UNDER the total runs line.
• Each of the Cubs’ last four games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cubs’ last eight road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last five night games against National League opponents.

Matchup/League Facts

• The Cardinals rank T1st in the league for walks allowed this season (211).
• The Cardinals rank T28th in the league for triples this season (4).
• The Cubs rank 2nd in the league for runs scored this season (417).
• The Cubs rank 2nd in the league for RBIs this season (409).

Cubs vs Cardinals Prediction

The Cubs are 4-1 in their last 5 overall meetings against the Cardinals, and the over is 5-1 in their last 6 meetings.

In this Cubs vs Cardinals Prediction, both teams are coming at a pick ’em price. The Cubs have a better overall record and have been above average on the road, but the Cardinals have been strong at home, with 24 wins. Both pitchers have been mediocre this season, with a combined 9.65 ERA, and both teams have elite offenses, averaging 10.3 runs per game combined. I expect a lot of runs in this game, especially while those two pitchers are on the mound. Take the over 5 runs in the first 5 innings of this game.

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