Cubs vs Cardinals Prediction 6/25/25 MLB Picks Today

The Chicago Cubs are visiting the Saint Louis Cardinals on Wednesday, June 25^th at the Busch Stadium in the third game of this series, with the Cardinals having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Cardinals Prediction. We will examine:

The Saint Louis Cardinals’ recent form and player performance

The Chicago Cubs’ recent form and player performance

Recent betting trends and streaks involving the Saint Louis Cardinals

Recent betting trends and streaks involving the Chicago Cubs

Recent betting trends in games played between the Chicago Cubs vs Saint Louis Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Chicago Cubs vs Saint Louis Cardinals game

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 44-36 record this season and are sitting in third place in the NL Central. The Cardinals have a 26-15 home record and are 43-34 in over/under. They are coming off an 8-7 home victory over the Cubs, and are 7-1 in their last 8 games. Over is 3-1 in their last 4 games, and they are playing the Guardians and the Pirates next.

The Cardinals have a .256 batting average this season, a .327 OBP, and a .399 Slugging percentage. Saint Louis’ pitching staff has a 3.94 ERA and 1.26 WHIP. Brendan Donovan leads the Cardinals with 87 hits and is the team’s best hitter with a .310 batting average. Wilson Contreras leads the team in RBI, with 50, while Lars Nootbaar adds a team-high 11 home runs.

Erick Fedde (R) is the projected starting pitcher for the Cardinals, and he has a 3-6 record, 3.54 ERA, and 1.30 WHIP. He has been weaker at home with a 4.36 ERA across six home starts, and he is coming off a quality start against the White Sox with one earned run across 5 innings pitched. Erick Fedde is 0-1 with an ERA of 6.33 and 26 strikeouts in 4 appearances against the Cubs in his career.

Chicago Cubs Preview

The Chicago Cubs have a 46-33 record this season and are sitting in first place in the NL Central. The Cubs have a 21-18 road record and are 40-31 in over/under. They are coming off a 7-8 road defeat by the Cardinals, and are 1-5 in their last 6 games. Over is 6-0 in their last 6 games, and they are playing the Astros and the Guardians next.

The Cubs have a .255 batting average this season, a .325 OBP, and a .443 Slugging percentage. Chicago’s pitching staff has a 3.95 ERA and 1.27 WHIP. Nico Hoerner leads the Cubs with 85 hits, and he is the team’s best hitter with a .294 batting average. Seiya Suzuki leads the team in RBI, with 67, adding a team-high 21 home runs.

Matthew Boyd (R) is the projected starting pitcher for the Cubs, and he has a 6-3 record, 2.84 ERA, and 1.14 WHIP. He has been weaker on the road, with a 3.22 ERA across eight road starts, and he has given up 2 runs or less in his last six starts. Matthew Boyd has a record of 1-1 with an ERA of 2.12 and 23 strikeouts in 3 appearances versus the Cardinals in his career.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last eight night games against National League opponents following a win.
• The Cubs have lost each of their last eight night games at Busch Stadium following a loss.
• The Cubs have failed to cover the run line in each of their last 12 Wednesday games against National League opponents.
• The Cardinals have covered the run line in each of their last eight night games against National League opponents following a win.
• The Cubs have trailed after 5 innings in each of their last six road games against National League opponents that held a winning record.
• The Cubs have trailed after 3 innings in each of their last eight Wednesday games against opponents that held a winning record.

Why the Chicago Cubs will win

• The Cubs have won 18 of their last 20 games following a road loss.
• The Cardinals have lost three of their last four games against the Cubs following a win.
• The Cubs have covered the run line in eight of their last nine road games following a road loss.
• The Cardinals have failed to cover the run line in five of their last six home games against the Cubs following a win.
• The Cubs have led after 3 innings in three of their last four games as favorites.

Total Runs Facts

• Each of the Cubs’ last six games have gone OVER the total runs line.
• Eight of the last nine games between the Cubs and Cardinals have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last seven night games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last five night games.

Matchup/League Facts

• The Cardinals rank T2nd in the league for walks allowed this season (215).
• The Cardinals rank T3rd in the league for hits this season (697).
• The Cubs rank 2nd in the league for runs scored this season (426).
• The Cubs rank 2nd in the league for RBIs this season (418).

Cubs vs Cardinals Prediction

The Cubs are 4-3 in their last 7 overall meetings against the Cardinals, but the Cardinals are 4-1 in their last 5 meetings in Saint Louis. Over is 7-1 in their last 8 meetings.

In this Cubs vs Cardinals Prediction, the Cubs are coming as -135 road favorites. Both teams have similar overall records, but Saint Louis has been strong at home, with 26 wins. The Cubs have the pitching advantage, as Boyd has been better than Fedde, who has been torched by the Cubs’ bats and has a 4.99 expected ERA. The Cubs also have a better bullpen, a better offense, and are slightly better against righties, while the Cardinals are significantly weaker against lefties. Take the Chicago Cubs to win o