Cubs vs Cardinals Prediction 5/29/26 MLB Picks Today

In this article, we will formulate a Cubs vs Cardinals Prediction for this MLB matchup on Friday, May 29^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 29-25 record this season and are sitting in the third place of the NL Central. They have a 13-13 home record and are coming off a 1-2 road defeat against the Brewers. They will face the Rangers and the Reds next.

The Cardinals have a .238 batting average this season, .318 OBP and .383 Slugging percentage. St. Louis’ pitching staff has a 4.22 ERA and 1.37 WHIP. Jordan Walker is the team’s best hitter with a .300 batting average, also leading the team in RBI with 42, adding a team-high 15 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 5-4 record, 3.76 ERA and 1.25 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 31-26 record this season and are sitting in the second place of the NL Central. They have a 13-15 away record and are coming off a 7-2 road win against the Pirates. They will face the Athletics and the Giants next.

The Cubs have a .238 batting average this season, .336 OBP and .387 Slugging percentage. Chicago’s pitching staff has a 4.19 ERA and 1.24 WHIP. Alex Bregman is the team’s best hitter with a .260 batting average. Nico Hoerner leads the team in RBI with 32, while Ian Happ adds a team-high 12 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 4-5 record, 4.04 ERA and 1.07 WHIP.

The Chicago Cubs @ St. Louis Cardinals Betting Trends: May 29, 2026

• Probable Starting Pitcher: Kyle Leahy      Record this season: 5-3      ERA: 4.44
• Home Record: 2-2
• Last 5 against Cubs: 0-0

Why the St. Louis Cardinals will win

• The Cubs have lost each of their last seven games as favorites.
• The underdogs have won seven of the Cubs’ last eight games.
• The Cubs have failed to cover the run line in each of their last seven games as favorites.
• The Cardinals have covered the run line in each of their last nine Friday games as home underdogs.
• The Cubs have trailed after 3 innings in five of their last six games as favorites.
• The Cubs have trailed after 5 innings in five of their last six games as favorites.

• Probable Starting Pitcher: Shota Imanaga      Record this season: 4-5      ERA: 4.04
• Road Record: 1-2
• Last 5 against Cardinals: 2-1

Why the Chicago Cubs will win

• The Cubs have won each of their last nine games against National League opponents following a win.
• The Cardinals have lost each of their last six games against NL Central opponents following a road loss.
• The Cubs have covered the run line in seven of their last eight road games against National League opponents following a road win.
• The Cardinals have failed to cover the run line in each of their last three night games against NL Central opponents.
• The Cubs have led after 3 innings in each of their last four games at Busch Stadium against opponents that held a winning record.
• The Cardinals have trailed after 5 innings in each of their last four home games.

Total Runs Facts

• Eight of the Cardinals’ last nine games as underdogs against National League opponents have gone UNDER the total runs line.
• Six of the Cubs’ last seven road games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last seven night games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last five games as favorites against National League opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one hit in each of the Cardinals’ last nine night games.
• Lars Nootbaar has hit a home run in two of his last three home appearances against the Cubs.
• Jordan Walker ranks 4th amongst qualified players for Slugging Percentage (.576) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in each of the Cubs’ last three games against the Cardinals.
• Shota Imanaga has recorded six or more strikeouts in each of his last three road appearances.
• Alex Bregman has recorded at least one hit in each of his last 14 road appearances.

Matchup/League Facts

• The Cardinals rank 27th in the league for strikeouts this season (414).
• The Cardinals rank 26th in the league for doubles this season (76).
• The Cubs rank 1st in the league for walks this season (261).
• The Cubs rank 30th in the league for home runs allowed this season (79).

Cubs vs Cardinals Prediction

The Cubs are 7-3 in their last 10 meetings against the Cardinals but have lost two of their last three visits in Saint Louis.

In this Cubs vs Cardinals Prediction, the Cubs are coming as -140 road favorites. The Jays have been dominating the Orioles in their recent meetings and they will face a struggling Trevor Rogers who has lost each of his last six starts and has 17 earned runs across his last three starts. On top of that, the Jays have a superior bullpen, they are 7-2 in their last 9 games and have just one earned run in each of their last three games, so I expect them to get the job done and win this one on the road.