Cubs vs Cardinals Prediction 7/5/25 MLB Picks Today

The St. Louis Cardinals and the Chicago Cubs meet Saturday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Matthew Liberatore for the start here and Liberatore is 6-6 with a 3.70 ERA and 76 strikeouts this season. In his career, Liberatore is 1-1 with a 4.26 ERA and 9 strikeouts against the Cubs. Drew Pomeranz will start this one for the Cubs and is 2-1 with a 0.00 ERA and 23 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from an 11-3 loss at the hands of the Cubs in Friday’s series opener to drop to 47-42 on the year. After this series, the Cardinals will head home for a series against the Washington Nationals.

Cardinals Drop Four In A Row

Brendan Donovan has a team-high 92 hits along with 22 doubles, 7 home runs and 32 RBIs while Lars Nootbaar has 70 hits with 11 home runs, 36 RBIs, 13 doubles and 4 stolen bases. Nolan Arenado also has 75 hits with 13 doubles, 10 home runs and 41 RBIs of his own and Victor Scott II has 61 hits with 9 doubles, a triple, 28 RBIs and a team-high 22 stolen bases. Willson Contreras has also chipped in 75 hits with 19 doubles, 11 home runs and 51 RBIs of his own as well this season. Masyn Winn’s added 75 points with 16 doubles, 7 home runs and 30 RBIs and Alec Burleson’s added 75 hits with 14 doubles, 10 home runs and 37 RBIs.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last nine Saturday games.
• The Cubs have lost five of their last six games as favorites against the Cardinals following a home win.
• The Cardinals have covered the run line in seven of their last eight games as road underdogs against National League opponents following a road loss.
• The Cubs have failed to cover the run line in six of their last seven games as home favorites against the Cardinals following a win.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has hit a home run in two of his last three appearances with the Cardinals as underdogs against the Cubs.
• Lars Nootbaar has recorded a hit in each of his last six appearances in day games.
• Victor Scott II ranks T6th in the league in Steals (22) this season.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over the Cardinals from Friday’s matchup to sit at 53-35 on the year. After this series, the Cubs will head on the road for a series against the Minnesota Twins.

Cubs Win Four In A Row

Ian Happ has 75 hits with 15 doubles, 12 home runs and 43 RBIs. Kyle Tucker has 93 hits including 18 doubles, 4 triples, 17 home runs and 52 RBIs while Seiya Suzuki also has 88 hits with 20 doubles and 24 home runs and 74 RBIs of his own. Miguel Amaya’s added 9 doubles and 25 RBIs and Pete Crow-Armstrong also has contributed 93 hits, 20 doubles, 4 triples, 23 home runs and 66 RBIs as well this season. Dansby Swanson has added 15 home runs and 42 RBIs, while also having 95 strikeouts and Suzuki has a team-high 99 strikeouts so far this season. Crow-Armstrong also has a team-high 26 stolen bases while Nico Hoerner has 15 stolen bases this season. Tucker’s also added 21 stolen bases while Michael Busch has also chipped in 13 doubles, 3 triples, 17 home runs and 55 RBIs this season.

Why the Chicago Cubs will win

• The Cardinals have lost each of their last six games against National League opponents.
• The home team has won each of the Cubs’ last five games.
• The Cardinals have failed to cover the run line each of their last five games at Wrigley Field against teams that held a winning record.
• The Cubs have covered the run line each of their last seven Saturday games against teams that held a winning record.

Chicago Cubs Player Prop Facts

• Dansby Swanson has hit a home run in each of the Cubs’ last two home games against NL Central opponents.
• Justin Turner has recorded at least one hit in 17 of his last 18 home appearances against NL Central opponents that held a winning record.
• Pete Crow-Armstrong ranks 3rd in the league in Steals (26) this season.

Total Runs Facts

• Seven of the Cardinals’ last eight games after playing the previous day have gone UNDER the total runs line.
• Five of the Cubs’ last six home games after playing the previous day have gone OVER the total runs line.

Cubs vs Cardinals Prediction

I’m on the Cardinals here. I get the case to be made for the Cubs in their current form, but the thing is that the Cubs haven’t been the same team as of late against lefties that they were early on in the year. Liberatore’s in great form, and while facing the same team twice in a quick timeframe is never easy, I think he can be good enough here for the Cards to snap out of this funk. Give me the Cardinals.