Cubs vs Cardinals Prediction 9/27/25 MLB Picks Today

In this article we will formulate a Cubs vs Cardinals prediction for this MLB game on Saturday, September 27th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 90-70 this season after they won game one by a score of 12-1 on Friday afternoon. Chicago had their lead cut to 4-1 in the seventh inning, but added eight late runs to run away with the win. The Cubs recorded 12 hits in the game and they were led by Suzuki, who went 1-4 with one home run and four RBIs in the win. Chicago started Rea, who allowed two hits and zero earned runs over 5.2 innings for the win, while Thielbar picked up a hold. 

Prior to this series, the Cubs lost two out of three against the Mets and all four against the Reds. Chicago has won two of their last three games and they are second in the NL Central standings. The Chicago pitching staff has a 3.82 ERA with a 1.18 WHIP and a .239 opponent batting average, while their offense has scored 784 runs with a .249 batting average and a .321 on base percentage this season. Seiya Suzuki has led Chicago with 30 home runs and 101 RBIs, while Pete Crow-Armstrong has added 30 home runs and 93 RBIs this year. The projected starting pitcher for Chicago is Jameson Taillon, who is 10-7 with a 3.78 ERA and a 1.07 WHIP over 123.2 innings pitched this season. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 78-82 this year after they lost game one by a score of 12-1 on Friday. St. Louis only scored once in the seventh inning and never really had a chance in the blowout loss. The Cardinals recorded five hits in the game and they were led by Walker, who went 1-3 with one RBI in the loss. St. Louis started Mikolas, who allowed four hits and four earned runs over 5.0 innings for the loss, while Graceffo allowed five earned runs in relief. 

Prior to this series, the Cardinals won two out of three against the Giants and two out of three against the Brewers. St. Louis has won three of their last five games and they are fourth in the NL Central standings. The St. Louis pitching staff has a 4.28 ERA with a 1.32 WHIP and a .259 opponent batting average, while their offense has scored 686 runs with a .246 batting average and a .315 on base percentage this season. Wilson Contreras (IL) has led St. Louis with 20 home runs, 80 RBIs, and five stolen bases, while Alec Burleson has added 18 home runs and 69 RBIs this year. The projected starting pitcher for St. Louis is Michael McGreevy, who is 8-3 with a 4.35 ERA and a 1.23 WHIP over 91.0 innings pitched this year. 

Why the Cubs will beat the Cardinals

• The Cubs have won each of their last six games against NL Central opponents that held a losing record.
• The Cardinals have lost seven of their last eight games at Wrigley Field against teams that held a winning record.
• The Cubs have covered the run line each of their last six games against National League opponents that held a losing record.
• The Cardinals have failed to cover the run line in seven of their last eight games at Wrigley Field against teams that held a winning record.
• The Cubs have won the first inning in each of their last three games against opponents that held a losing record.
• The Cubs have led after 3 innings in seven of their last eight games as home favorites against National League opponents.
• The Cardinals have trailed after 5 innings in eight of their last nine road day games.

Total Runs Facts

• Seven of the Cubs’ last eight home games have gone OVER the total runs line.
• Each of the Cardinals’ last four day games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four games at Wrigley Field.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four day games between the Cardinals and Cubs at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in three of the Cubs’ last four home games against the Cardinals.
• Nico Hoerner has recorded two hits in each of the Cubs’ last six day games against opponents that held a losing record.
• Ian Happ has recorded a Double in three of the Cubs’ last four games.
• Jameson Taillon has recorded a win in each of his last seven appearances in day games against teams that held a losing record.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded at least one hit in each of his last eight appearances.
• Nolan Gorman has hit a home run in three of the Cardinals’ last four Saturday day games as underdogs.
• Brendan Donovan has recorded at least one Double in four of his last five appearances.

Cubs vs Cardinals Prediction 

Chicago was able to score a bunch of runs late in game one for the blowout win, which they are hoping will jump start their offense heading into the playoffs. The Cubs are 48-31 at home this year, while the Cardinals are 34-45 on the road. St. Louis has had issues with their pitching all season and they are starting McGreevy, who has allowed 5+ earned runs in two of his last four starts. Chicago is going with Taillon, who has allowed two earned runs or fewer in five straight outings. Take the Cubs -1.5 here.