Cubs vs Dodgers Prediction 4/22/25 MLB Picks Today

The Los Angeles Dodgers and the Chicago Cubs meet Sunday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Dodgers Prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Dustin May for the start here and May is 1-1 with a 1.06 ERA and 14 strikeouts this season. This will be May’s second career start against the Cubs. Shota Imanaga will get the start for the Cubs here and Imanaga is 2-1 with a 2.22 ERA and 21 strikeouts this season. In his career, Imanaga is 1-0 with a 1.80 ERA and 9 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this series looking to build on their 1-0 win over Texas in Sunday’s rubber match to win the series and improve to 16-7 on the year. After this series, the Dodgers will head home for a series with the Pittsburgh Pirates.

Dodgers Win 5 Of Last 6

Shohei Ohtani leads the Dodgers with 23 hits including 6 home runs while Tommy Edman has 23 hits with a team-high 7 home runs and 15 RBIs. Michael Conforto has 13 hits with 4 doubles while Teoscar Hernandez has 20 hits with 5 home runs, 4 doubles and 17 RBIs as well this season. Ohtani has a team-high 5 stolen bases while Max Muncy has 5 doubles but also has the team lead with 28 strikeouts so far this season. Mookie Betts has also chipped in 4 home runs and 10 RBIs as well on the year.

Why the Los Angeles Dodgers will win

• The Cubs have lost seven of their last eight night games after going to extra innings.
• The favorites have won each of the Dodgers’ last six games.
• The Cubs have failed to cover the run line in five of their last six night games after going to extra innings.
• The Dodgers have covered the run line in four of their last five night games against NL Central opponents.

Los Angeles Dodgers Player Prop Facts

• Tommy Edman has hit a home run in three of the Dodgers’ last four night games against opponents that held a winning record.
• Tommy Edman has recorded at least one RBI in five of his last six appearances against the Cubs after not playing the previous day.
• Teoscar Hernandez has recorded at least one Single in each of the Dodgers’ last 10 night games against opponents that held a winning record.
• Tommy Edman has scored at least one run in nine of the Dodgers’ last 10 night games against opponents that held a winning record.
• Teoscar Hernandez has recorded at least one hit in each of the Dodgers’ last 10 night games against opponents that held a winning record.
• Esteury Ruiz has recorded a Double in three of his last four road appearances against NL Central opponents.
• Tommy Edman ranks T5th in the league in Home Runs (7) this season.

Chicago Cubs Recap

The Chicago Cubs come into this set looking to bounce back after a 3-2 loss at the hands of the Arizona Diamondbacks on Sunday to fall to 14-10 on the year. After this series, the Cubs will square off against the Philadelphia Phillies at home.

Cubs Fail To Complete Sweep Vs. Arizona

Kyle Tucker leads the Cubs with 29 hits including team-highs of 8 doubles, 6 home runs and 23 RBIs while Seiya Suzuki also has 22 hits with a pair of doubles and 6 home runs and 18 RBIs of his own. Miguel Amaya’s added 6 doubles and 12 RBIs and Pete Crow-Armstrong also has contributed 8 doubles as well this season. Dansby Swanson has added 4 home runs and 12 RBIs, while he also has the unfortunate distinction of leading the Cubs with 30 strikeouts so far this season. Crow-Armstrong also has a team-high 8 stolen bases while Nico Hoerner has 6 stolen bases this season. Michael Busch has also chipped in 5 home runs and 16 RBIs this season.

Why the Chicago Cubs will win

• The Cubs have won four of their last five games as underdogs following a loss.
• The Dodgers have lost four of their last five games as road favorites against National League opponents.
• The Dodgers have failed to cover the run line in each of their last five games as road favorites against National League opponents.
• The Cubs have covered the run line in four of their last five games as underdogs against NL West opponents following a loss.

Chicago Cubs Player Prop Facts

• Carson Kelly has hit two home runs in two of his last three appearances with the Cubs as underdogs against NL West opponents.
• Kyle Tucker has recorded a Double in three of the Cubs’ last four games against the Dodgers.
• Seiya Suzuki has recorded at least one RBI in five of the Cubs’ last six games against the Dodgers at Wrigley Field.
• Shota Imanaga has recorded five or more strikeouts in 12 of his last 16 appearances at Wrigley Field.
• Ian Happ has scored at least one run in each of the Cubs’ last seven home games.
• Nico Hoerner has recorded at least one Single in each of the Cubs’ last eight Tuesday games against opponents that held a winning record.
• Kyle Tucker has recorded at least one hit in 17 of his last 18 Tuesday night appearances against teams that held a winning record.
• Shota Imanaga has recorded a win in four of his last five appearances at Wrigley Field.
• Pete Crow-Armstrong ranks T2nd in the league in Steals (8) this season.

Total Runs Facts

• Each of the Cubs’ last six games after going to extra innings have gone UNDER the total runs line.
• Each of the Dodgers’ last four road games against National League opponents have gone OVER the total runs line.

Cubs vs Dodgers Prediction

I’m on the Cubs in this one. I think it should be a great pitching matchup, as these are two of the better or best starters in their respective rotations that have gotten off to fantastic starts this season. That being said, if there’s one weakness with this Dodger lineup, it’s that they’ve struggled against lefties this season. I think the Cubs can do enough against May and the Dodger bullpen to get the win at home in this one. Give me the Cubbies.