Cubs vs Giants Prediction 5/5/25 MLB Picks Today

In this article, we will formulate a Cubs vs Giants prediction for this MLB game on Monday, May 5, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (22-13, 10-8 Away) responded to a three-game losing skid with three consecutive wins. After losing Game 1 of the series against the Colorado Rockies, the Giants won the next three games. In the latest 9-3 victory, Willy Adames led the team with three RBI, while Logan Webb got the win after allowing one run on six hits with six strikeouts and two walks over 7.0 innings of work.

This season, the Giants average 4.69 runs per game (11th in the MLB) on a .231/.310/.387 slash line. Regarding pitching, the Giants’ staff has a 3.44 ERA (6th) and 1.22 WHIP (10th). Wilmer Flores leads the Giants with a .240 batting average, seven home runs, and 31 RBI this season.

The projected starting pitcher for the Giants is Landen Roupp, who is 2-2 in six starts this season, with a 5.10 ERA and 1.63 WHIP in 30.0 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (21-14, 9-7 Home) were on a three-game winning run but couldn’t make it four straight after losing 4-0 to the Milwaukee Brewers. The Cubs did win that series and the one before against the Pirates. Shota Imanaga took the loss in the most recent game after allowing two runs on four hits with four strikeouts and one walk in 5.2 innings.

This year, the Cubs average 5.94 runs per game (1st in the MLB) on a .262/.339/.455 triple-slash. When it comes to pitching, the Cubs’ staff has a 3.82 ERA (14th) and 1.29 WHIP (19th). Kyle Tucker leads the Cubs with a .292 batting average, nine home runs, and 30 RBI this season.

Matthew Boyd will take the mound for the Cubs on Monday. The 34-year-old right-hander has a 2-2 record in six starts this year with a 2.70 ERA and 1.44 WHIP in 33.1 innings.

Why the Cubs will beat the Giants

• The Cubs have won each of their last eight games against National League opponents following a road loss.
• The Giants have lost each of their last seven games at Wrigley Field against teams that held a winning record.
• The Giants have failed to cover the run line in each of their last six night games against National League opponents following a home win.
• The Cubs have covered the run line in four of their last five games against National League opponents following a road loss.
• The Cubs have led after 3 innings in six of their last seven games at Wrigley Field against NL West opponents that held a winning record.
• The Cubs have led after 5 innings in seven of their last eight home games against NL West opponents.

Total Runs Facts

• Each of the Giants’ last 10 games as road underdogs have gone OVER the total runs line.
• Four of the Cubs’ last five games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the last 11 night games between the Giants and Cubs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Giants’ last 10 games as underdogs against NL Central opponents.

Matchup/League Facts

• The Cubs rank T1st in the league for triples this season (9).
• The Cubs rank 1st in the league for RBIs this season (204).
• The Giants rank T6th in the league for strikeouts this season (305).
• The Giants rank 24th in the league for batting average this season (.231).

Cubs vs Giants Prediction

The Cubs won six of the previous ten H2H encounters, but the Giants were better in three of the last four. I am backing the Cubs here because I like their starting pitcher better. Matthew Boyd has three quality starts so far and hasn’t allowed more than three runs in a game yet. Also, the Giants have a .220 BA in 336 at-bats against southpaws this season, and I am sure Boyd will do well. Landen Roupp is the weakest of all the Giants’ starters, and he’ll get into trouble early on against the highest-scoring offense in the MLB.