Cubs vs Guardians Prediction 4/4/26 MLB Picks Today

In this article, we will formulate a Cubs vs Guardians Prediction for this MLB matchup on Saturday, April 4^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview

The Guardians have a 5-3 record this season and are sitting in the first place of the AL Central. They have a 1-0 home record and are coming off a 4-1 home win over the Cubs. Their previous three games were a 4-1 road win, a 1-4 road loss and a 4-2 road win to the Dodgers.

The Guardians have a .203 batting average this season, .287 OBP and .348 Slugging percentage. Cleveland’s pitching staff has a 3.60 ERA and 1.21 WHIP. Chase DeLauter is the team’s best hitter with a .346 batting average, also leading the team in RBI with 8 and adding a team-high 5 home runs.

Slade Cecconi (R) is the projected starting pitcher for the Guardians, and he has a 0-1 record, 12.46 ERA and 2.08 WHIP.

Chicago Cubs Preview

The Cubs have a 3-4 record this season and are sitting in the last place of the NL Central. They have a 0-1 road record and are coming off a 1-4 road loss to the Guardians. Their previous three games were a 6-2 home win, a 0-2 home loss and a 7-2 home win over the Angels.

Chicago has a .222 batting average this season, .315 OBP and .342 Slugging percentage. Chicago’s pitching staff has a 3.63 ERA and 1.16 WHIP. Nico Hoerner is the team’s best hitter with a .292 batting average. Ian Happ leads the team in RBI with 5, also adding a team-high 3 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-1 record, 7.20 ERA and 1.60 WHIP.

The Chicago Cubs @ Cleveland Guardians Betting Trends: April 4, 2026

• Probable Starting Pitcher: Slade Cecconi      Record this season: 0-1      ERA: 12.46
• Home Record: 0-0
• Last 5 against Cubs: –

Why the Cleveland Guardians will win

• The Cubs have lost each of their last eight road games.
• The home team has won each of the last seven games between the Cubs and Guardians.
• The Guardians have covered the run line in 11 of their last 12 games as underdogs against National League opponents.
• The Cubs have failed to cover the run line in seven of their last eight road games against teams that held a winning record.
• The Guardians have led after 3 innings in three of their last four games against National League opponents that held a losing record.
• The Cubs have trailed after 5 innings in five of their last six road games.

• Probable Starting Pitcher: Shota Imanaga      Record this season: 0-1      ERA: 7.20
• Road Record: 0-0
• Last 5 against Guardians: 1-0

Why the Chicago Cubs will win

• The Guardians have lost each of their last eight night games against NL Central opponents.
• The Cubs have won each of their last eight games as road favorites against American League opponents following a road loss.
• The Cubs have covered the run line in each of their last eight games as road favorites against American League opponents following a road loss.
• The Guardians have failed to cover the run line in each of their last seven Saturday home games against National League opponents.
• The Guardians have trailed after 3 innings in each of their last four home games against NL Central opponents.
• The Guardians have trailed after 5 innings in five of their last six night games against NL Central opponents.
• The Cubs have won the first inning in each of their last five Saturday games against American League opponents that held a winning record.

Total Runs Facts

• Eight of the Guardians’ last nine games as underdogs against National League opponents have gone UNDER the total runs line.
• Seven of the Cubs’ last eight games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last 14 games between the Cubs and Guardians.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last 10 games at Progressive Field.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four home games against NL Central opponents that held a losing record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 12 games against NL Central opponents that held a losing record.

Chicago Cubs Player Prop Facts

• Shota Imanaga has recorded five or more strikeouts in three of his last four appearances against AL opponents.
• Seiya Suzuki has recorded a hit in each of his last eight appearances with the Cubs as favorites.
• Seiya Suzuki has hit at least one home run in three of his last four appearances in night games.
• Nico Hoerner ranks T1st in the league in Steals (4) this season.

Matchup/League Facts

• The Guardians rank 27th in the league for batting average this season (.203).
• The Guardians rank 4th in the league for strikeouts this season (83).
• The Cubs rank 4th in the league for steals this season (8).
• The Cubs rank T5th in the league for walks this season (32).

Cubs vs Guardians Prediction

The Cubs are 3-1 in their last 4 head-to-head matches against the Guardians but the Guardians have won their last four head-to-head home matches.

In this Cubs vs Guardians Prediction, the Cubs are coming as -140 road favorites. Cleveland won the opening game of this series but they have a major pitching disadvantage today, as Slade Cecconi goes up against Shota Imanaga. Both pitchers looked terrible in their first starts of the season, having given up 4 and 6 runs respectively. has given up 3 runs in each of his two previous starts against the Guardians and both teams are way better against the opposing starter throw hand, averaging 9.9 runs per game combined, so take the over 8 in this one.