Cubs vs Marlins Prediction 9/23/26 MLB Picks Today
Miami Marlins (77-80) vs. Chicago Cubs (87-70)
September 23, 2026 7:40 pm EDT
The Line: Chicago Cubs -179 / Miami Marlins 147; Over/Under: 6.5
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In this article we will formulate a Cubs vs Marlins prediction for this MLB game on Wednesday, September 23rd at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.
Chicago Cubs Betting Preview
The Chicago Cubs are 87-70 this season after they lost game one by a score of 8-2 in 12 innings. The Cubs erased a 2-0 deficit in the sixth inning, but they failed to score in three extra innings for the loss. Chicago recorded seven hits in the game and they were led by Happ, who went 1-6 with one RBI. Imanaga allowed four hits and one earned run over 5.0 innings, while Thielbar picked up the loss. Prior to this series, Chicago won two out of three against the Reds and two out of three against the Braves.
This season, Chicago has a 4.17 ERA with a 1.26 WHIP and a .243 opponent batting average, while they have scored 837 runs with a .251 batting average and a .339 on base percentage. Pete Crow-Armstrong has led the Cubs with 45 home runs and 107 RBIs, while Dansby Swanson has added 19 home runs and 67 RBIs. The projected starting pitcher for Chicago is Kevin Gausman, who is 9-12 with a 4.55 ERA and a 1.27 WHIP over 172.0 innings pitched this season.
Miami Marlins Betting Preview
The Miami Marlins are 77-80 this year after they won game one in extra innings by a score of 8-2. Miami blew a 2-0 lead in the sixth, but they erupted for six runs in the 12th for the win. The Marlins recorded 11 hits and they committed one error in the game, while they were led by Stowers, who went 2-4 with one home run and two RBIs. Junk allowed two hits and zero earned runs over 5.0 innings, while Ekness picked up the win in relief. Prior to this series, Miami lost all three against the Padres, but did win two out of three against the Diamondbacks before that.
This season, Miami has a 4.13 ERA with a 1.29 WHIP and a .236 opponent batting average, while they have scored 700 runs with a .249 batting average and a .327 on base percentage. Otto Lopez has led the Marlins with 11 home runs and 71 RBIs, while Owen Caissie has added 14 home runs and 58 RBIs. The projected starting pitcher for Miami is Ryan Gusto, who is 1-5 with a 4.14 ERA and a 1.44 WHIP over 82.2 innings pitched this year.
Why the Chicago Cubs will win
- The Marlins have lost each of their last six night games at Wrigley Field following a win.
- The Cubs have won nine of their last 10 night games against NL East opponents that held a losing record.
- The Marlins have failed to cover the run line in each of their last six night games at Wrigley Field following a win.
- The Cubs have covered the run line in eight of their last nine games as home favorites following a home loss.
- The Cubs have led after 5 innings in seven of their last eight home games.
- The Cubs have led after 3 innings in five of their last six home games against NL East opponents.
Why the Miami Marlins will win
- The Marlins have won three of their last four games as underdogs after going to extra innings.
- The Cubs have lost four of their last five home games against teams that held a losing record.
- The Marlins have covered the run line in each of their last 10 road games against NL Central opponents following a win.
- The Cubs have failed to cover the run line in six of their last seven home games after going to extra innings.
- The Marlins have led after 3 innings in three of their last four night games.
- The Cubs have trailed after 5 innings in each of their last three games against NL East opponents that held a losing record.
Total Runs Facts
- Each of the Cubs’ last seven home games against NL East opponents have gone OVER the total runs line.
- Each of the Marlins’ last four games have gone OVER the total runs line.
- There has been no run scored during the first inning in each of the Marlins’ last 14 games against NL Central opponents.
- There has been no run scored during the first inning in 16 of the Cubs’ last 18 games against NL East opponents.
Chicago Cubs Player Prop Facts
- Seiya Suzuki has hit a home run in three of the Cubs’ last four home games against NL East opponents that held a losing record.
- Kevin Gausman has recorded a win in three of his last four home appearances against NL opponents.
- Ian Happ has recorded at least one hit in each of the Cubs’ last nine home games against NL East opponents that held a losing record.
- Kevin Gausman has recorded six or more strikeouts in each of his last six appearances against NL opponents.
- Pete Crow-Armstrong ranks T1st in the league in Home Runs (45) this season.
Miami Marlins Player Prop Facts
- Kyle Stowers has hit at least one home run in each of the Marlins’ last three road games against the Cubs.
- Ryan Gusto has recorded four or more strikeouts in each of his last four road appearances.
- Xavier Edwards has recorded at least one hit in each of his last eight appearances in night games against NL Central teams that held a winning record.
- Otto Lopez ranks 1st in the league in Hits (186) this season.
Matchup/League Facts
- The Cubs rank 1st in the league for runs scored this season (837).
- The Cubs rank T1st in the league for home runs this season (217).
- The Marlins rank T2nd in the league for steals this season (160).
- The Marlins rank 3rd in the league for triples this season (35).
Cubs vs Marlins Prediction
Miami was able to snap their losing streak with a win on Tuesday in game one and they have scored 6+ runs in two of their last three games. The Marlins are 32-47 on the road this year, while the Cubs are 45-34 at home. Chicago has won three of their last five games and they have scored 5+ runs in all three of those wins. The Cubs are starting Gausman, who has allowed 1, 6, 1, 5, and 0 earned runs in his last five starts, while Gusto has allowed two earned runs or fewer in four of his last five outings. Take the Marlins and the plus money here.