Cubs vs Phillies Prediction 4/15/26 MLB Picks Today

In this article, we will formulate a Cubs vs Phillies Prediction for this MLB matchup on Wednesday, April 15^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 8-9 record this season and are sitting in the third place of the NL East. They have a 5-6 home record and are coming off a 4-10 home loss against the Cubs. Their previous three games were a 13-7 home win against the Cubs, and a 4-3 home loss and a 4-3 home win to the Diamondbacks.

The Phillies have a .233 batting average this season, .315 OBP and .382 Slugging percentage. Philadelphia’s pitching staff has a 4.62 ERA and 1.36 WHIP. Brandon Marsh is the team’s best hitter with a .305 batting average. Kyle Schwarber leads the team in RBI with 12, also adding a team‑high 6 home runs.

Jesus Luzardo (L) is the projected starting pitcher for the Phillies, and he has a 1-2 record, 6.23 ERA and 1.15 WHIP.

Chicago Cubs Preview

The Chicago Cubs have an 8-9 record this season and are sitting in the fifth place of the NL Central. They have a 4-4 away record and are coming off a 10-4 road win against the Phillies. Their previous three games were a 13-7 road loss to the Phillies, and a 7-6 home win and a 4-3 home loss to the Pirates.

The Cubs have a .239 batting average this season, .336 OBP and .371 Slugging percentage. Chicago’s pitching staff has a 3.99 ERA and 1.19 WHIP. Carson Kelly is the team’s best hitter with a .333 batting average. Nico Hoerner leads the team in RBI with 13, and Ian Happ adds a team‑high 4 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-1 record, 2.81 ERA and 0.81 WHIP.

The Chicago Cubs @ Philadelphia Phillies Betting Trends: April 15, 2026

• Probable Starting Pitcher: Jesus Luzardo      Record this season: 1-2      ERA: 6.23
• Home Record: 0-2
• Last 5 against Cubs: 2-0

Why the Philadelphia Phillies will win

• The Phillies have won each of their last 13 Wednesday night games against National League opponents that held a losing record.
• The Cubs have lost eight of their last nine road games against National League opponents.
• The Phillies have covered the run line each of their last nine Wednesday night games against National League opponents that held a losing record.
• The Cubs have failed to cover the run line in each of their last six games as underdogs against the Phillies following a win.
• The Cubs have trailed after 3 innings in each of their last five games as underdogs against NL East opponents.
• The Cubs have trailed after 5 innings in seven of their last eight games as road underdogs against National League opponents.
• The Cubs have lost the first inning in three of their last four games at Citizens Bank Park against opponents that held a losing record.

• Probable Starting Pitcher: Shota Imanaga      Record this season: 0-1      ERA: 2.81
• Road Record: 0-0
• Last 5 against Phillies: 0-0

Why the Chicago Cubs will win

• The Phillies have lost four of their last five games as favorites against NL Central opponents.
• The Cubs have won eight of their last nine games against National League opponents that held a losing record.
• The Phillies have failed to cover the run line in nine of their last 10 home games.
• The Cubs have covered the run line in eight of their last nine games against National League opponents that held a losing record.
• The Cubs have led after 5 innings in eight of their last 10 night games against National League opponents that held a losing record.

Total Runs Facts

• Seven of the Cubs’ last eight games against NL East opponents have gone OVER the total runs line.
• Four of the Phillies’ last five night games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cubs’ last eight games as underdogs against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in three of the Phillies’ last four home games against NL Central opponents.

Philadelphia Phillies Player Prop Facts

• Kyle Schwarber has hit at least one home run in three of the Phillies’ last five home games against NL opponents that held a losing record.
• Jesus Luzardo has recorded a win in four of his last five appearances with the Phillies as favorites against NL opponents.
• Jesus Luzardo has recorded seven or more strikeouts in each of his last 10 appearances with the Phillies as favorites.
• Brandon Marsh has recorded at least one hit in each of his last 13 appearances in night games against teams that held a losing record.
• Kyle Schwarber ranks T3rd in the league in Home Runs (6) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in three of his last four appearances against opponents that held a losing record.
• Shota Imanaga has recorded a win in five of his six previous appearances in night games against NL teams that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of his last 11 appearances against NL East opponents.
• Carson Kelly ranks 3rd amongst qualified players for On Base Percentage (.455) this season.

Matchup/League Facts

• The Phillies rank 2nd in the league for strikeouts this season (175).
• The Phillies rank T2nd in the league for walks allowed this season (45).
• The Cubs rank 2nd in the league for walks this season (83).
• The Cubs rank T4th in the league for hits allowed this season (123).

Cubs vs Phillies Prediction

The Phillies are 5-2 in their last 7 meetings against the Cubs and are 4-2 in their last 6 meetings in Philadelphia.

In this Cubs vs Phillies Prediction, the Phillies are coming as -135 home favorites. The Cubs have the pitching advantage here, as Imanaga has been much better than Luzardo so far. Shota has just one earned run in his last two starts, while Luzardo has 5+ earned runs in two of his three starts this season. On top of that, the Cubs have a better bullpen ERA and a better offense, while the Phillies are weaker against left-handed pitching. I like the Cubs as road dogs in this spot, so take them on the moneyline for plus money.