
Cubs vs Phillies Prediction 4/27/25 MLB Picks Today
Philadelphia Phillies (13-13) vs. Chicago Cubs (17-10)
April 27, 2025 7:00 pm EDT
The Line: Chicago Cubs -102 / Philadelphia Phillies -118; Over/Under: 0.0001
(Get latest betting odds)
The Philadelphia Phillies and the Chicago Cubs meet Sunday in MLB action from Wrigley Field. This will be the final installment in a three-game weekend series. Here’s a Cubs vs Phillies prediction. We will look at this from a betting perspective and determine the best Cubs vs Phillies pick.
Philadelphia Phillies Betting Preview
Philly opened up their season with a series victory versus the Washington Nationals, then took a sweep over the Colorado Rockies next. Philadelphia would then beat the Los Angeles Dodgers in a three-game series before a loss in a set versus the Braves. Philadelphia lost in the next series against St. Louis, then took a split in four games against the Giants. Last weekend Philadelphia beat the Marlins in two of three games but didn’t play very well in their last series versus the Mets. Philly got swept in that one 5-4, 5-1 and 4-3. On Friday in the opener versus the Cubs, Philadelphia couldn’t get anything going on five team hits in a 4-0 shutout defeat. JT Realmuto had two of those hits, and Taijuan Walker went 3.0 innings with two earned runs on six hits and two walks.
In the Saturday game Philly bagged 12 team hits on the way to a 10-4 victory. Both Bryce Harper (two walks) and Kyle Schwarber (run) had two RBI apiece. Starter Jesus Luzardo put up 6.0 clean innings with three hits, three walks and five Ks.
Starter for Sunday’s finale will be Aaron Nola. In his five starts so far Nola is 0-5 with a 6.43 ERA in 28.0 innings total. Over his career Nola is 104-84 with a 3.75 ERA in 273 starts.
Chicago Cubs Betting Preview
Over on the Cubs’ side, they took a split in four games versus the Arizona Diamondbacks in their opening set, then swept the Oakland Athletics before of a set win versus the San Diego Padres. Chicago then bagged a victory in another series against the Texas Rangers. Next was a series win over the Los Angeles Dodgers in two of three games. After a set loss to the Padres, the Cubs managed to get wins in two of three during the rematch with the Diamondbacks last weekend. Chicago beat the Dodgers in both their games this past week, eking them out 11-10 and 7-6. On Friday versus the Phillies, the Cubs posted 11 team hits on the way to the victory. Starter Colin Rea picked up the win with 5.0 innings, two walks and seven strikeouts over 92 pitches.
In the Saturday matchup Chicago gave up six runs in the fourth innings during the loss. Ben Brown posted six earned on nine hits and a walk in just 3.2 frames as starter.
Jameson Taillon will take the mound for the start on Sunday. This year Taillon is 1-1 with a 4.73 ERA in five starts across 26.2 innings. In his career Taillon is 72-54 with a 3.91 ERA in 206 games (205 starts).
Cubs vs Phillies Prediction
I’ll stay with the Cubs. Taillon has been getting progressively better over his last three starts, even though he hasn’t registered a decision in any of them. First came three earned in 6.0 innings versus the Rangers, then two earned in 5.1 frames against the Padres. In his most recent appearance Taillon gave up just one earned run on three hits and two walks over 5.0 innings against the Diamondbacks on April 20. As for Nola, he’s had some issues this year. Over his last two starts Nola has given up 10 earned in 11.2 innings on 16 hits and six walks. He’s obviously a better pitcher than that though, so it wouldn’t be surprising to see Nola dominate at any time.
Chicago got buried by the six-run fourth inning on Saturday, but the offense didn’t perform too badly overall. I like the Cubs to bounce back in the finale.