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Cubs vs Pirates Prediction 4/10/26 MLB Picks Today

Pittsburgh Pirates (7-5) vs. Chicago Cubs (6-6)
April 10, 2026 2:20 pm EDT
The Line: Chicago Cubs -156 / Pittsburgh Pirates 129; Over/Under: 6.5
(Get latest betting odds)

In this article we will formulate a Cubs vs Pirates prediction for this MLB game on Friday, April 10th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 6-6 this year after they won two out of three against the Rays by scores of 4-6, 9-2, and 6-2. In their game three win, Chicago was tied at one in the fifth inning, but they scored five runs in the fifth to pull away with the win. The Cubs recorded eight hits and they were led by Conforto and Hoerner, who both had two RBIs in the game. Rea allowed two hits and one earned run over 5.0 innings for the win, while Brown allowed one earned run in relief. Prior to that series, Chicago lost two out of three against the Guardians, but did win two out of three against the Angels before that. 

This season, Chicago has a 3.43 ERA with a 1.12 WHIP and a .211 opponent batting average, while they have scored 56 runs with a .223 batting average and a .312 on base percentage. Ian Happ has led the Cubs with four home runs and seven RBIs, while Nico Hoerner has added one home run and nine RBIs. The projected starting pitcher for Chicago is Shota Imanaga, who is 0-1 with a 4.50 ERA and a 1.20 WHIP over 10.0 innings pitched this year. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 7-5 this season after they lost two out of three against the Padres by scores of 0-5, 7-1, and 2-8. In their game three loss, Pittsburgh cut the deficit to 4-2 in the seventh inning, but they allowed four runs in the ninth to seal the loss. The Pirates recorded six hits and they committed three errors in the game, while they were led by Griffin and Bart, who both had one RBI. Keller allowed three hits and zero earned runs over 6.0 innings in the no decision, while Lawrence picked up the loss in relief. Prior to that series, Pittsburgh swept the Orioles in three games and won two out of three against the Reds. 

This season, Pittsburgh has a 3.33 ERA with a 1.30 WHIP and a .220 opponent batting average, while they have scored 54 runs with a .247 batting average and a .338 on base percentage. Oneil Cruz has led the Pirates with four home runs and 12 RBIs, while Ryan O’Hearn has added three home runs and 11 RBIs. The projected starting pitcher for Pittsburgh is Carmen Mlodzinski, who is 0-0 with a 4.00 ERA and a 1.56 WHIP over 9.0 innings pitched this season. 

Why the Chicago Cubs will win

  • The Cubs have won 13 of their last 14 day games at Wrigley Field following a road win.
  • The Pirates have lost each of their last six games against NL Central opponents following a home loss.
  • The Pirates have failed to cover the run line in 12 of their last 13 road games against National League opponents following a home loss.
  • The Cubs have covered the run line in four of their last five games against the Pirates.
  • The Cubs have won the first inning in four of their last five home games against NL Central opponents.
  • The Cubs have led after 3 innings in each of their last four home games against opponents that held a winning record.
  • The Cubs have led after 5 innings in eight of their last nine home games against NL Central opponents.

Why the Pittsburgh Pirates will win

  • The Cubs have lost each of their last four games as favorites following a win.
  • The Pirates have won six of their last eight games as road underdogs against the Cubs following a loss.
  • The Pirates have covered the run line in each of their last eight road games against the Cubs following a loss.
  • The Cubs have failed to cover the run line in each of their last seven home games against the Pirates following a win.
  • The Pirates have led after 3 innings in each of their last five Friday games.
  • The Cubs have trailed after 5 innings in three of their last four games against National League opponents.

Total Runs Facts

  • Six of the last seven games between the Pirates and Cubs at Wrigley Field have gone UNDER the total runs line.
  • Five of the Pirates’ last six games as road underdogs have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Pirates’ last four games as underdogs.

Chicago Cubs Player Prop Facts

  • Seiya Suzuki has recorded at least one hit in each of his last 14 home appearances.
  • Shota Imanaga has recorded six or more strikeouts in six of his seven previous home appearances against NL Central opponents.
  • Seiya Suzuki has hit a home run in three of the Cubs’ last four games as favorites against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

  • Bryan Reynolds has hit a home run in each of the Pirates’ last two road games.
  • Oneil Cruz has recorded at least one hit in each of the Pirates’ last eight games.

Cubs vs Pirates Prediction 

Pittsburgh comes into this series after dropping two out of three against the Padres, but they have had a very solid start to the season. The Pirates are 3-3 on the road this year, while the Cubs are 3-3 at home. Chicago just won two out of three against the Rays and they have scored 5+ runs in three of their last four. Both offenses have been high scoring and even with the wind blowing in, I like the over here. 

David Racey's Free Pick: Over 6.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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